STRINGSTRING
stan stan Cad88C Cad88C shg shg Cad96Cb Cad96Cb ft ft ds ds Cad87A Cad87A Cad99C Cad99C CadN CadN Cad89D Cad89D Cad86C Cad86C CadN2 CadN2 Cad74A Cad74A kug kug
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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stanProtocadherin-like wing polarity protein stan; Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields. During planar cell polarity, stabilizes asymmetric PCP domains together with ATP6AP2. (3648 aa)
Cad88CCadherin 88C (Cad88C) encodes a member of the cadherin superfamily of transmembrane proteins, which mediate cell-cell adhesion and/or cell-cell communication. (1981 aa)
shgDE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...] (1507 aa)
Cad96CbCadherin 96Cb, isoform D; Calcium ion binding. It is involved in the biological process described with: homophilic cell adhesion via plasma membrane adhesion molecules; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; cell-cell adhesion mediated by cadherin; open tracheal system development. (789 aa)
ftCadherin-related tumor suppressor; Involved in regulation of planar cell polarity in the compound eye where it is required for correct specification of the R3 and R4 photoreceptor cells by regulating Fz activity in the R3/R4 precursor cells. This is likely to occur through creation of an ft gradient so that the equatorial R3/R4 precursor cell has a higher level of ft function than its polar neighbor. Also required for planar cell polarity of wing hairs. Mediates heterophilic cell adhesion in vitro and is required to stabilize ds on the cell surface. Involved in regulation of eye imagin [...] (5147 aa)
dsProtein dachsous; Required for normal morphogenesis of adult structures derived from imaginal disks. Plays a role in planar cell polarity and in determining body left-right asymmetry. Expression in segment H1 of the imaginal ring and interaction with Myo31DF are required to induce changes of cell shape and orientation in segment H2, which then gives rise to normal, dextral looping of the adult hindgut. (3556 aa)
Cad87ACadherin-87A; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity). (1975 aa)
Cad99CCadherin-99C; Cadherin that functions in epithelial morphogenesis and the intestine epithelial immune response. Essential for female fertility. Regulates the length and organization of apical microvilli in developing follicle cells and salivary glands. Function in the follicle cell is essential for egg development as the microvilli secrete eggshell material such as the vitelline membrane. Acts at least in part by regulating the recruitment of the myosin ck to the follicle cell microvilli. Also required to regulate cell rearrangements during salivary tube elongation, possibly by modulat [...] (1706 aa)
CadNNeural-cadherin; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information. (3101 aa)
Cad89DCadherin-89D; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity). (2240 aa)
Cad86CCadherin-86C; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity). (1949 aa)
CadN2Putative neural-cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity). (1799 aa)
Cad74ACadherin 74A (Cad74A) encodes a non-classical cadherin involved in cell-cell adhesion. (1820 aa)
kugFat-like cadherin-related tumor suppressor homolog; Required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells. Required for proper egg chamber shape and elongation of the egg chamber during oogenesis. Required for the correct planar polarization of Rab10 within the basal follicle cell epithelium and is therefore indirectly involved in the Rab10-dependent remodeling of the basal membrane during egg chamber elongation. (4699 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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