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Max Max Fer2 Fer2 crp crp Met Met tx tx Fer1 Fer1 dimm dimm Myc Myc HLH4C HLH4C trh trh Usf Usf Mitf Mitf Mnt Mnt ss ss tai tai gce gce Mondo Mondo net net h h Clk Clk CG33557 CG33557 HLH54F HLH54F Hey Hey dpn dpn cato cato bigmax bigmax FBgn0002733 FBgn0002733 E(spl)m5-HLH E(spl)m5-HLH E(spl)m8-HLH E(spl)m8-HLH E(spl)m7-HLH E(spl)m7-HLH E(spl)m3-HLH E(spl)m3-HLH FBgn0002735 FBgn0002735 FBgn0002734 FBgn0002734 nau nau sim sim Fer3 Fer3 cwo cwo tgo tgo ato ato Sidpn Sidpn amos amos Oli Oli Hand Hand tap tap cyc cyc SREBP SREBP Hesr Hesr emc emc HLH3B HLH3B ase ase l(1)sc l(1)sc sc sc ac ac da da sage sage twi twi sima sima
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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from curated databases
experimentally determined
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MaxMax (Max) encodes a member of the basic-helix-loop-helix-zipper family of transcription factors. It specifically forms heterodimers with the products of Myc and Mnt enabling the binding and transcriptional activity of the heterodimeric complex, which regulate genes involved in cell and organismal growth. (161 aa)
Fer248 related 2 (Fer2) encodes a bHLH-transcription factor required for the development of a subset of circadian pacemaker neurons and dopaminergic neurons in the protocerebral anterior medial (PAM) and the protocerebral anterior lateral clusters. It is also required for the survival of the PAM cluster dopaminergic neurons in adulthood. (283 aa)
crpActivator protein 4; Cropped (crp) encodes a transcription factor that controls cellular branching of the terminal cells at the ends of tracheal tubes. As a downstream target gene of the product of Myc, it affects cell growth, organ size and survival. (631 aa)
MetMethoprene-tolerant, isoform A; Methoprene-tolerant (Met) encodes bHLH-PAS domain transcription factor paralogous to gce. It is a receptor for the sesquiterpenoid juvenile hormone. (716 aa)
txHelix-loop-helix protein delilah; Taxi (tx) encodes a transcription factor that affects cell adhesion by regulating the expression of mys. It is involved in the development of multiple organs and cell-types including tendon cells, chordotonal organs and the wing. (384 aa)
Fer148 related 1 (Fer1) encodes a basic helix loop helix (bHLH) transcription factor. It is mainly expressed in mature neurons and maintains neuronal identity, likely downstream of the product of N. (256 aa)
dimmProtein dimmed; Transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate. Acts as a master regulator of common NS functions such as Phm expression and neuropeptide production. Plays a role as a regulator of peptide-containing large dense-core vesicle (LDCV) production and peptidergic cell differentiation. Controls transcription of FMRFamide in Tv neuronal cells and Fur1 in Ap-let cells (Tvb and dorsal apterous cells). Also required for up- regulation of Phm in Tv and Ap-let cells, and expression of three neuropeptide genes, Ms, FMRFamide and Lk [...] (390 aa)
MycMyc protein; Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiqui [...] (717 aa)
HLH4CHelix loop helix protein 4C, isoform B; RNA polymerase II regulatory region sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (191 aa)
trhProtein trachealess; Transcription factor, master regulator of tracheal cell fates in the embryo, necessary for the development of the salivary gland duct, Malpighian tubules and the posterior spiracles. It may induce a general fate of branched tubular structures of epithelial origin. Functions with tgo to regulate expression of btl. (1022 aa)
UsfUsf, isoform B; Usf (Usf) encodes a bHLH family transcription factor that recognizes E-boxes in the Ste promoter. (437 aa)
MitfMitf, isoform C; Mitf (Mitf) encodes a b-HLH-Zip transcription factor that regulates basic cellular processes in part by controlling the expression of the vacuolar (H[+])-ATPase subunits. (837 aa)
MntMnt, isoform I; Mnt (Mnt) encodes a protein that belongs to the basic-helic-loop-helix-zipper class of transcription factors, which form heterodimers with the protein encoded by Max. Mnt product acts as a repressor of transcription by recruiting a co-repressor complex to its genomic binding sites. It antagonizes cell growth promoting functions of the product encoded by Myc and its depletion produces flies with larger cells, increased weight, and decreased lifespan. (790 aa)
ssSpineless, isoform C; Spineless (ss) encodes a protein that plays a key role in defining the distal regions of the antenna and the leg. Its stochastic expression in R7 photoreceptors also controls the expression of color Rhodopsins (the product of Rh4 vs. the product of Rh3) in the two subsets of ommatidia. (1015 aa)
taiTaiman, isoform G; Taiman (tai) encodes an ecdysone receptor co-activator related to mammalian steroid receptor coactivator (SRC) proteins. It contributes to border cell migration. (2047 aa)
gceGerm cell-expressed bHLH-PAS (gce) encodes a bHLH-PAS domain transcription factor paralogous to the product of Met. It is a receptor for the sesquiterpenoid juvenile hormone. (959 aa)
MondoMlx interactor alpha; Mondo (Mondo) encodes a basic helix-loop-helix-leucine zipper transcription factor involved in lipid and carbohydrate metabolism. Together with its binding partner encoded by bigmax, it controls sugar-dependent gene expression, including activation of genes involved in lipogenesis. Mondo mutants are intolerant to dietary sugars and have impaired muscle function. (1119 aa)
netNet, isoform B; Net (net) encodes a basic helix-loop-helix protein that probably acts as a transcriptional repressor. During wing vein formation it is expressed in all interveins territories and antagonises the activity of the product of Egfr. (360 aa)
hHairy (h) encodes a bHLH transcriptional repressor that recruits the corepressor encoded by gro to target promoters. It is a pair-rule gene that contributes to embryonic segmentation and peripheral neurogenesis. (337 aa)
ClkCircadian locomoter output cycles protein kaput; Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced [...] (1027 aa)
CG33557BHLH domain-containing protein; RNA polymerase II regulatory region sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II. (150 aa)
HLH54FRT01030p; HLH54F (HLH54F) encodes a bHLH transcription factor that regulates caudal visceral mesoderm development. (242 aa)
HeyHairy/E(spl)-related with YRPW motif (Hey) encodes a transcription factor involved in neuron fate determination. Hey expression is regulated by Notch signalling in the embryonic and larval central nervous system. (425 aa)
dpnProtein deadpan; Transcriptional repressor of genes that require a bHLH protein for their transcription. In the larval brain, required to maintain the self- renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm together with other self-renewal transcriptional repressors such as klu and E(spl)mgamma- HLH. As part of its role in neuroblasts development, has been shown to be a direct target of the Notch signaling pathway, however might work also independently of N/Notch. In the developing larval and pupal brain, required for mushroom [...] (435 aa)
catoCousin of atonal (cato) encodes a transcription factor involved in the development of the sensory nervous system. (189 aa)
bigmaxGM14426p; Bigmax (bigmax) encodes a basic helix-loop-helix-leucine zipper transcription factor. Together with its binding partner encoded by Mondo, the product of bigmax is involved in sugar-dependent gene regulation. It is involved in transcriptional control of many metabolic pathways, including glycolysis, de novo lipogenesis and the pentose phosphate pathway. Loss of bigmax function produces dietary sugar intolerance. (254 aa)
FBgn0002733Enhancer of split mbeta protein; Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Contributes to the neural-epidermal lineage decision during early neurogenesis. Part of the Notch signaling pathway. (195 aa)
E(spl)m5-HLHEnhancer of split m5 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. (178 aa)
E(spl)m8-HLHEnhancer of split m8 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Part of the Notch signaling pathway. (179 aa)
E(spl)m7-HLHEnhancer of split m7 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. (186 aa)
E(spl)m3-HLHEnhancer of split m3 protein; Transcriptional repressor of genes that require a bHLH protein for their transcription. May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Belongs to notch signaling pathway and depends on Su(H) for transcriptional activation. (224 aa)
FBgn0002735Enhancer of split mgamma protein; Transcriptional repressor of genes that require a bHLH protein for their transcription. May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Contributes to the neural-epidermal lineage decision during early neurogenesis. Part of the Notch signaling pathway, plays a role in neuroblasts proliferation in embryos and larvae. In the larval brain, together with other self-renewal transcriptional repressors such as klu and dpn, required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermedi [...] (205 aa)
FBgn0002734Enhancer of split mdelta protein; Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Contributes to the neural-epidermal lineage decision during early neurogenesis. As part of the Notch signaling pathway, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm. (173 aa)
nauNautilus (nau) encodes a protein that belongs to the bHLH family of transcription factors. It is the unique Drosophila ortholog of the mammalian family of bHLH Myogenic Regulatory Factors. It is involved in somatic muscle myogenesis. (332 aa)
simProtein single-minded; Transcription factor that functions as a master developmental regulator controlling midline development of the ventral nerve cord. Required to correctly specify the formation of the central brain complex, which controls walking behavior. Also required for correct patterning of the embryonic genital disk and anal pad anlage. Plays a role in synapse development. (688 aa)
Fer3Protein Fer3; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity). (195 aa)
cwoTranscription factor cwo; Plays a role in the regulation of circadian rhythms. Transcriptional repressor which inhibits Clock-mediated transcriptional activation by binding to E boxes in the promoters of Clock target genes and repressing their transcription. E box binding activity is time- dependent with higher binding activity seen in the early morning (zeitgeber time 2) than early evening (zeitgeber time 14) and is dependent on the presence of the circadian protein per. It is likely that per binds to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo [...] (698 aa)
tgoAryl hydrocarbon receptor nuclear translocator homolog; Heterodimers of tgo/trh are involved in the control of breathless expression. Plays a role in the cellular or tissue response to oxygen deprivation. (642 aa)
atoProtein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection. (312 aa)
SidpnSimilar to deadpan; Protein dimerization activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of neurogenesis; anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; cell differentiation; regulation of transcription, DNA-templated. (507 aa)
amosBasic helix-loop-helix transcription factor amos; Transcription factor involved in early neurogenesis; sensillum basiconica formation and maybe sensillum trichodea development. Promotes multiple dendritic (MD) neuron formation. Required for olfactory sensilla; regulated by lozenge (lz). (198 aa)
OliOlig family, isoform A; Protein dimerization activity. It is involved in the biological process described with: motor neuron axon guidance; regulation of transcription, DNA-templated. (232 aa)
HandFI14601p; Hand (Hand) encodes a transcription factor that contributes to cardiogenesis, hemopoiesis, and muscle function. (174 aa)
tapBasic helix-loop-helix neural transcription factor TAP; May play a role in the specification of the sugar-sensitive adult gustatory neuron and affect the response to sugar and salt. Regulated by POXN. (398 aa)
cycProtein cycle; Putative transcription factor involved in the generation of biological rhythms. Activates cycling transcription of Period (PER) and Timeless (TIM) by binding to the E-box (5'-CACGTG-3') present in their promoters. (413 aa)
SREBPSterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. (1113 aa)
HesrHES-related; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein dimerization activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; anterior/posterior pattern specification; regulation of neurogenesis; cell differentiation. (149 aa)
emcProtein extra-macrochaetae; Participates in sensory organ patterning by antagonizing the neurogenic activity of the Achaete-scute complex (AS-C). It lacks a basic DNA-binding domain but is able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. May sequester proneural proteins in complexes inefficient for DNA interaction. EMC also affects vein differentiation. Inhibits the activity of AS-C proteins by forming an non-DNA binding heterodimer. (199 aa)
HLH3BHelix loop helix protein 3B; Protein dimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (376 aa)
aseAchaete-scute complex protein T8; Asense (ase) encodes a transcription factor in the achaete-scute complex. It acts together with other proneural genes in nervous system development, which involves N-mediated lateral inhibition. ase is expressed in the CNS type-I neuroblasts and the PNS sensory organ precursors (SOPs) but not in the proneural clusters that give rise to the SOP via lateral inhibition. (486 aa)
l(1)scAchaete-scute complex protein T3; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. (257 aa)
scAchaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation. (345 aa)
acAchaete-scute complex protein T5; Achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development. (201 aa)
daDaughterless (da) encodes a class I bHLH protein important for sex determination and dosage compensation by controlling the feminizing switch gene Sxl. It participates in transcriptional regulation of a wide variety processes, including oogenesis, neurogenesis, myogenesis and cell proliferation. (775 aa)
sageSalivary gland-expressed bHLH (sage) is only expressed in embryonic salivary glands. The product of sage works with the product of fkh to activate expression of salivary gland specific gene products (secreted proteins and enzymes that modify the secreted proteins). (268 aa)
twiTwist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells. (490 aa)
simaProtein similar; Functions as a transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. (1593 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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