(43 nodes) Chaperone J-domain superfamily network (Drosophila melanogaster)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CG11035	LD38634p. (231 aa)
	l(3)80Fg	FI01132p; It is involved in the biological process described with: cell redox homeostasis. (780 aa)
	Tpr2	Tetratricopeptide repeat protein 2, isoform A; Heat shock protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding. (508 aa)
	DnaJ-H	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding. (440 aa)
	CG5001	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding. (350 aa)
	CG43322	J domain-containing protein; It is involved in the biological process described with: Golgi vesicle prefusion complex stabilization; Golgi organization; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. (359 aa)
	mrj	Mrj, isoform E; Unfolded protein binding; chaperone binding. It is involved in the biological process described with: chaperone-mediated protein folding; chaperone cofactor-dependent protein refolding; protein folding. (346 aa)
	CG10565	LD23875p; DNA binding. (646 aa)
	DnaJ-60	DnaJ-like protein 60; May play an important function during spermatogenesis and/or in the male genital tract. (217 aa)
	CG7394	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). (128 aa)
	CG1409	Uncharacterized protein; It is involved in the biological process described with: protein import into mitochondrial matrix. (150 aa)
	Hsc20	Heat shock protein cognate 20 (Hsc20) encodes a mitochondrial chaperone that facilitates iron sulfur cluster assembly or transfer from the product of IscU to other scaffold proteins. Hsc20 is required for larval growth and cellular iron sensing. (240 aa)
	CG5504	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. (520 aa)
	Rme-8	Receptor mediated endocytosis 8 (Rme-8) encodes a protein involved in the regulation of border follicle cell migration and the endocytosis of the receptor encoded by N. (2408 aa)
	CG8531	LD27406p; ATPase activator activity. It is involved in the biological process described with: cristae formation; protein import into mitochondrial matrix. (545 aa)
	jdp	J domain-containing protein; Unfolded protein binding; chaperone binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding. (195 aa)
	CG10375	LD07883p. (254 aa)
	CG3061	RH07106p; Hsp70 protein binding. It is involved in the biological process described with: ubiquitin-dependent ERAD pathway; chaperone cofactor-dependent protein refolding; cellular response to misfolded protein. (370 aa)
	CG8476	J domain-containing protein. (242 aa)
	Droj2	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding. (403 aa)
	CG6693	J domain-containing protein CG6693; Heat shock protein binding. (299 aa)
	CG17187	RE47242p; Nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (299 aa)
	P58IPK	LD25575p; Misfolded protein binding; chaperone binding. It is involved in the biological process described with: protein folding in endoplasmic reticulum. (498 aa)
	aux	Auxilin, isoform A; Auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death. (1165 aa)
	CG14650	LD26442p. (970 aa)
	Dph4	RE24848p; It is involved in the biological process described with: peptidyl-diphthamide biosynthetic process from peptidyl-histidine; tRNA wobble uridine modification. (183 aa)
	CG7133	LD30543p. (353 aa)
	CG7130	GEO11142p1. (128 aa)
	shv	DnaJ homolog shv; Maintains stem cell niche architecture in the testes. Activates an extracellular integrin beta-PS pathway which regulates DE- cadherin (shg) levels in somatic hub cells, and is essential for maintaining the number of germline stem cells and the structure and localization of hub cells. (354 aa)
	DnaJ-1	DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. (334 aa)
	Sec63	Secretory 63; Protein transmembrane transporter activity; RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation. (753 aa)
	CG7387	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization. (449 aa)
	CG7872	DnaJ homolog subfamily C member 25 homolog; It is involved in the biological process described with: protein folding. (333 aa)
	CG32640	J domain-containing protein. (132 aa)
	CG12020	J domain-containing protein; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding. (366 aa)
	CG2790	LD43587p; Nucleic acid binding; zinc ion binding. (540 aa)
	CG2887	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding. (342 aa)
	CG32727	GEO10507p1; ATPase activator activity. It is involved in the biological process described with: protein import into mitochondrial matrix. (122 aa)
	blp	Mitochondrial import inner membrane translocase subunit Tim16; Black pearl (blp) encodes a conserved mitochondrial inner membrane protein. Its loss decreases cytochrome c oxidase activity and causes ROS production, leading to melanotic lesions ("black pearls") in blp-deficient flies; Belongs to the TIM16/PAM16 family. (141 aa)
	CG30156	AT29763p; Hsp70 protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding; cellular response to misfolded protein; ubiquitin-dependent ERAD pathway. (358 aa)
	wus	Wurst, isoform A; Wurst (wus) encodes a transmembrane protein essential for clathrin-mediated endocytosis. It recruits the product of Hsc70-4 and clathrin to the apical cell membrane of epithelial cells. The endocytosis mediated by the product of wus is required for size determination and lumen clearance of the airways. (406 aa)
	CG7556	GH07340p; DNA binding. (522 aa)
	Csp	DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. (249 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG10375	CG43322	FBpp0083849	FBpp0297779	LD07883p.	J domain-containing protein; It is involved in the biological process described with: Golgi vesicle prefusion complex stabilization; Golgi organization; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum.	0.407
CG10375	CG7872	FBpp0083849	FBpp0073862	LD07883p.	DnaJ homolog subfamily C member 25 homolog; It is involved in the biological process described with: protein folding.	0.430
CG10375	Droj2	FBpp0083849	FBpp0082220	LD07883p.	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding.	0.446
CG10375	aux	FBpp0083849	FBpp0078604	LD07883p.	Auxilin, isoform A; Auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death.	0.583
CG10565	CG2790	FBpp0293954	FBpp0072315	LD23875p; DNA binding.	LD43587p; Nucleic acid binding; zinc ion binding.	0.488
CG10565	CG3061	FBpp0293954	FBpp0082332	LD23875p; DNA binding.	RH07106p; Hsp70 protein binding. It is involved in the biological process described with: ubiquitin-dependent ERAD pathway; chaperone cofactor-dependent protein refolding; cellular response to misfolded protein.	0.652
CG10565	CG7556	FBpp0293954	FBpp0309972	LD23875p; DNA binding.	GH07340p; DNA binding.	0.533
CG10565	DnaJ-H	FBpp0293954	FBpp0303024	LD23875p; DNA binding.	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding.	0.492
CG10565	Droj2	FBpp0293954	FBpp0082220	LD23875p; DNA binding.	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding.	0.512
CG10565	Sec63	FBpp0293954	FBpp0076558	LD23875p; DNA binding.	Secretory 63; Protein transmembrane transporter activity; RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation.	0.551
CG10565	aux	FBpp0293954	FBpp0078604	LD23875p; DNA binding.	Auxilin, isoform A; Auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death.	0.617
CG11035	CG7130	FBpp0312540	FBpp0078137	LD38634p.	GEO11142p1.	0.821
CG11035	jdp	FBpp0312540	FBpp0085043	LD38634p.	J domain-containing protein; Unfolded protein binding; chaperone binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding.	0.523
CG12020	CG7387	FBpp0072661	FBpp0076446	J domain-containing protein; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding.	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization.	0.473
CG12020	DnaJ-H	FBpp0072661	FBpp0303024	J domain-containing protein; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding.	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding.	0.640
CG12020	Droj2	FBpp0072661	FBpp0082220	J domain-containing protein; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding.	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding.	0.640
CG1409	CG32727	FBpp0271880	FBpp0071014	Uncharacterized protein; It is involved in the biological process described with: protein import into mitochondrial matrix.	GEO10507p1; ATPase activator activity. It is involved in the biological process described with: protein import into mitochondrial matrix.	0.929
CG1409	CG7394	FBpp0271880	FBpp0288463	Uncharacterized protein; It is involved in the biological process described with: protein import into mitochondrial matrix.	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).	0.926
CG1409	CG7556	FBpp0271880	FBpp0309972	Uncharacterized protein; It is involved in the biological process described with: protein import into mitochondrial matrix.	GH07340p; DNA binding.	0.840
CG1409	blp	FBpp0271880	FBpp0311409	Uncharacterized protein; It is involved in the biological process described with: protein import into mitochondrial matrix.	Mitochondrial import inner membrane translocase subunit Tim16; Black pearl (blp) encodes a conserved mitochondrial inner membrane protein. Its loss decreases cytochrome c oxidase activity and causes ROS production, leading to melanotic lesions ("black pearls") in blp-deficient flies; Belongs to the TIM16/PAM16 family.	0.560