STRINGSTRING
Hsc70-2 Hsc70-2 Hsc70-3 Hsc70-3 Arp6 Arp6 Arp8 Arp8 Hex-A Hex-A Act57B Act57B Gk1 Gk1 CG1271 CG1271 CG11594 CG11594 Tcs3 Tcs3 Hsc70-1 Hsc70-1 Arp3 Arp3 fbl fbl Hsp70Ab Hsp70Ab Hsp70Bbb Hsp70Bbb Hsp70Bb Hsp70Bb Arp1 Arp1 Hsc70-4 Hsc70-4 CG6218 CG6218 Act87E Act87E Arp10 Arp10 Act5C Act5C Gk2 Gk2 CG7182 CG7182 Arp53D Arp53D Act79B Act79B CG3544 CG3544 Arp2 Arp2 CG14231 CG14231 CG8298 CG8298 Hsc70Cb Hsc70Cb CG2918 CG2918 Hsc70-5 Hsc70-5 Hex-C Hex-C Bap55 Bap55 Act42A Act42A Hex-t2 Hex-t2 Hex-t1 Hex-t1 Hsp68 Hsp68 Arp5 Arp5 CG3534 CG3534 Act88F Act88F
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Hsc70-2Heat shock protein cognate 2 (Hsc70-2) encodes a member of the heat shock protein 70 family. It functions as chaperone protein in facilitating the proper folding of proteins. (633 aa)
Hsc70-3Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). (656 aa)
Arp6Actin-related protein 6; Nucleosome binding; chromatin binding. It is involved in the biological process described with: histone exchange; heterochromatin organization; Belongs to the actin family. ARP6 subfamily. (398 aa)
Arp8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity); Belongs to the actin family. ARP8 subfamily. (607 aa)
Hex-APhosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis. (541 aa)
Act57BActin-57B; Actin 57B (Act57B) is one of several actin genes in the Drosophila genome, and one of the few that encode myofibrillar actin. This essential gene is a transcriptional target of Mef2 and Cf2 and is expressed in all embryonic muscles and a subset of adult muscle. (376 aa)
Gk1Glycerol kinase activity; phosphotransferase activity, alcohol group as acceptor. It is involved in the biological process described with: glycerol metabolic process; phosphorylation; triglyceride metabolic process; glycerol-3-phosphate biosynthetic process. (538 aa)
CG1271HL01494p; Glycerol kinase activity; phosphotransferase activity, alcohol group as acceptor. It is involved in the biological process described with: glycerol-3-phosphate biosynthetic process; triglyceride metabolic process; phosphorylation; glycerol metabolic process. (556 aa)
CG11594RH40737p; D-ribulokinase activity. It is involved in the biological process described with: response to endoplasmic reticulum stress; carbohydrate metabolic process. (548 aa)
Tcs3Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (347 aa)
Hsc70-1Heat shock 70 kDa protein cognate 1. (641 aa)
Arp3Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline. (418 aa)
fblFumble, isoform E; Fumble (fbl) encodes an enzyme that phosphorylates pantothenate (vitamin B5), which is one of the early steps of the Coenzyme A de novo biosynthesis pathway. (512 aa)
Hsp70AbHeat-shock-protein-70Ab (Hsp70Ab) encodes a protein involved in response to heat shock and hypoxia. (642 aa)
Hsp70BbbHsp70Bbb (Hsp70Bbb) encodes a protein involved in response to heat shock and hypoxia. (641 aa)
Hsp70BbHeat-shock-protein-70Bb (Hsp70Bb) encodes a protein involved in response to hypoxia heat shock and. (641 aa)
Arp1Actin-related protein 1 (Arp1) encodes the short filamentous component of the Dynactin complex, which plays an essential role in the activation of the Dynein microtubule motor protein. As such, the Arp1 product is required for diverse cellular processes such as intracellular transport, mitotic spindle assembly, chromosome movements, and nuclear positioning. (376 aa)
Hsc70-4Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. (651 aa)
CG6218GH07590p; N-acetylglucosamine kinase activity. It is involved in the biological process described with: carbohydrate phosphorylation. (348 aa)
Act87EActin-87E; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (376 aa)
Arp10Actin-related protein 10 (Arp10) encodes a component of the dynactin multiprotein complex that is involved in microtubule-based movement; Belongs to the actin family. (378 aa)
Act5CActin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
Gk2Glycerol kinase activity; phosphotransferase activity, alcohol group as acceptor. It is involved in the biological process described with: glycerol metabolic process; glycerol-3-phosphate biosynthetic process; triglyceride metabolic process; phosphorylation. (576 aa)
CG7182LD21269p; Belongs to the heat shock protein 70 family. (513 aa)
Arp53DActin-like protein 53D; It is involved in the biological process described with: mitotic cytokinesis; Belongs to the actin family. ARP1 subfamily. (411 aa)
Act79BActin, larval muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (376 aa)
CG3544GH10780p; Xylulokinase activity; phosphotransferase activity, alcohol group as acceptor. It is involved in the biological process described with: phosphorylation; carbohydrate phosphorylation; xylulose metabolic process. (572 aa)
Arp2Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (399 aa)
CG14231Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (409 aa)
CG8298RE20574p; Phosphotransferase activity, alcohol group as acceptor; glycerol kinase activity. It is involved in the biological process described with: glycerol metabolic process; phosphorylation; triglyceride metabolic process; glycerol-3-phosphate biosynthetic process. (596 aa)
Hsc70CbHsc70Cb, isoform G; Hsc70Cb (Hsc70Cb) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. (836 aa)
CG2918EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. (923 aa)
Hsc70-5Heat shock 70 kDa protein cognate 5. (686 aa)
Hex-CPhosphotransferase; Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis. (454 aa)
Bap55Brahma associated protein 55kD (Bap55) encodes a member of two chromatin remodeling complexes. As part of the Brahma complex, it is needed for cell growth and survival in the wing imaginal disc; as a member of the TIP60 complex, it is thought to regulate dendrite wiring specificity in olfactory projection neurons; Belongs to the actin family. (425 aa)
Act42AActin-42A; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
Hex-t2Hexokinase type 2; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (486 aa)
Hex-t1Hexokinase type 1; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (465 aa)
Hsp68Heat shock protein 68 (Hsp68) encodes a protein involved in lifespan determination and response to heat shock and starvation. (635 aa)
Arp5Actin-related protein 5; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (648 aa)
CG3534LD23605p; Xylulokinase activity; phosphotransferase activity, alcohol group as acceptor. It is involved in the biological process described with: phosphorylation; xylulose metabolic process; carbohydrate phosphorylation. (552 aa)
Act88FActin, indirect flight muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Required for proper formation of indirect flight muscle (IFM) myofibrils; Belongs to the actin family. (376 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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