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| | Rtca | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity). (361 aa) |
| | CG10802 | LD13611p; Ser-tRNA(Ala) hydrolase activity; ATP binding; nucleic acid binding; alanine-tRNA ligase activity. It is involved in the biological process described with: alanyl-tRNA aminoacylation; regulation of translational fidelity. (436 aa) |
| | CG18155 | MIP16841p; Very long-chain fatty acid-CoA ligase activity; malonyl-CoA synthetase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process; malonate catabolic process. (610 aa) |
| | alpha-PheRS | Phenylalanyl-tRNA synthetase, alpha-subunit (alpha-PheRS) encodes a cytoplasmic aminoacyl-tRNA synthetase that catalyzes the ligation of Phenylalanine to its cognate tRNAPhe. Together with the beta-subunit it forms a tetrameric enzyme complex. This subunit provides the catalytic core. (498 aa) |
| | LysRS | Lysine--tRNA ligase; tRNA binding; ATP binding; lysine-tRNA ligase activity. It is involved in the biological process described with: lysyl-tRNA aminoacylation. (607 aa) |
| | CG9993 | Uncharacterized protein; CoA-ligase activity; fatty acid ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (543 aa) |
| | CG17999 | GH16244p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (545 aa) |
| | DNAlig1 | DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (747 aa) |
| | Fatp3 | Fatty acid transport protein 3, isoform A; Long-chain fatty acid-CoA ligase activity; very long-chain fatty acid-CoA ligase activity; long-chain fatty acid transporter activity. It is involved in the biological process described with: fatty acid biosynthetic process; triglyceride homeostasis. (687 aa) |
| | CG4563 | RE01528p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (537 aa) |
| | TyrRS-m | Tyrosine--tRNA ligase, mitochondrial; Tyrosyl-tRNA synthetase, mitochondrial (TyrRS-m) encodes an enzyme that catalyzes the ligation of tyrosine to the mitochondrial-encoded tRNA-Tyr. The TyrRS-m protein is encoded by a nuclear gene and imported to the mitochondria where it functions in mitochondrial protein synthesis; Belongs to the class-I aminoacyl-tRNA synthetase family. (464 aa) |
| | ProRS-m | Prolyl-tRNA synthetase, mitochondrial, isoform A; proline-tRNA ligase activity; ATP binding; glycine-tRNA ligase activity. It is involved in the biological process described with: glycyl-tRNA aminoacylation; prolyl-tRNA aminoacylation. (458 aa) |
| | Scsalpha1 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (328 aa) |
| | TTLL1B | Tubulin tyrosine ligase-like 1B; Tubulin binding; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity. It is involved in the biological process described with: protein polyglutamylation; microtubule cytoskeleton organization; protein polyglycylation. (487 aa) |
| | LeuRS-m | Leucyl-tRNA synthetase, mitochondrial; aminoacyl-tRNA editing activity; leucine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: leucyl-tRNA aminoacylation; mitochondrial translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (869 aa) |
| | Fpgs | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (572 aa) |
| | Paics | Phosphoribosylaminoimidazole-succinocarboxamide synthase; PAICS bifunctional enzyme (Paics) encodes an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the N-terminal section; belongs to the SAICAR synthetase family. (429 aa) |
| | Nadsyn | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan. (787 aa) |
| | DNAlig4 | DNA ligase 4 (DNAlig4) encodes an ATP-dependent DNA ligase responsible for the sealing of DNA double-strand breaks during the canonical non-homologous end joining pathway of DNA repair. It interacts with the product of XRCC4 for stability and DNA ligase activity. (918 aa) |
| | ArgRS | Probable arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. (665 aa) |
| | TTLL1A | Tubulin tyrosine ligase-like 1A; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; protein polyglycylation; protein polyglutamylation. (496 aa) |
| | CG3961 | LD09909p; Long-chain fatty acid-CoA ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process; long-chain fatty acid metabolic process. (704 aa) |
| | TrpRS-m | Tryptophanyl-tRNA synthetase, mitochondrial (TrpRS-m) encodes a protein predicted to function within mitochondria to catalyze the ligation of tryptophan to its cognate tRNA to form tryptophanyl-tRNA. (665 aa) |
| | TyrRS | tRNA binding; tyrosine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: tyrosyl-tRNA aminoacylation. (525 aa) |
| | GluRS-m | Glutamyl-tRNA synthetase, mitochondrial; glutamate-tRNA ligase activity; tRNA binding; ATP binding; zinc ion binding. It is involved in the biological process described with: glutamyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (511 aa) |
| | GlyRS | Glycyl-tRNA synthetase, isoform B; Glycyl-tRNA synthetase (GlyRS) encodes a protein involved in dendrite morphogenesis and larval lymph gland hemopoiesis. (765 aa) |
| | Ube3a | Ubiquitin protein ligase E3A (Ube3a) encodes the founding member of the HECT-type ubiquitin E3 ligase family of enzymes. It is involved in the final step of conjugation of ubiquitin to its target substrates. It regulates protein degradation by targeting modified proteins to the proteasome or by regulating the proteasome activity through ubiquitination of its subunits, which in turn affects many aspects of neuronal function, such as synaptic plasticity, long-term memory or dendritic development. (973 aa) |
| | CG5568 | LD47944p; CoA-ligase activity; fatty acid ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (545 aa) |
| | ScsbetaG | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (416 aa) |
| | AlaRS-m | Alanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (1012 aa) |
| | Naprt | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family. (667 aa) |
| | CG31773 | AT16211p; Tetrahydrofolylpolyglutamate synthase activity; ATP binding. It is involved in the biological process described with: tetrahydrofolylpolyglutamate biosynthetic process; folic acid-containing compound biosynthetic process. (758 aa) |
| | SerRS | Seryl-tRNA synthetase (SerRS) encodes a protein that aminoacylates transfer RNAs (tRNA) for their use by the ribosome during protein synthesis. (501 aa) |
| | Gs1 | Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. (399 aa) |
| | AcCoAS | Acetyl-coenzyme A synthetase; Activates acetate so that it can be used for lipid synthesis or for energy generation; Belongs to the ATP-dependent AMP-binding enzyme family. (670 aa) |
| | IleRS | Isoleucyl-tRNA synthetase, isoform A; isoleucine-tRNA ligase activity; tRNA binding; aminoacyl-tRNA editing activity; ATP binding. It is involved in the biological process described with: isoleucyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (1229 aa) |
| | CG12512 | MIP06029p; Medium-chain fatty acid-CoA ligase activity; fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid metabolic process; fatty acid biosynthetic process. (593 aa) |
| | Pfas | Phosphoribosylformylglycinamidine synthase (Pfas) encodes a phosphoribosylformylglycinamidine synthase, which is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the N-terminal section; belongs to the FGAMS family. (1354 aa) |
| | TTLL3A | Tubulin glycylase 3A; Polylycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved both in the side-chain initiation and elongation steps of the polyglycylation reaction by adding a single glycine chain to generate monoglycine side chains and by elongating monoglycine side chains to polyglycine side chains. (992 aa) |
| | bgm | Very long-chain-fatty-acid--CoA ligase bubblegum; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Probably by regulating lipid storage and catabolism, plays a role in neuronal function. (666 aa) |
| | hll | Long-chain-fatty-acid--CoA ligase heimdall; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Probably by regulating lipid storage and catabolism, plays a role in neuronal function ; Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. (681 aa) |
| | RtcB | RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs; Belongs to the RtcB family. (506 aa) |
| | TrpRS | Tryptophanyl-tRNA synthetase (TrpRS) is expressed to high levels in the salivary gland. This could be incidental due to proximity to the salivary gland transcription factor encoded by sage; Belongs to the class-I aminoacyl-tRNA synthetase family. (430 aa) |
| | pug | C-1-tetrahydrofolate synthase, cytoplasmic; Pugilist (pug) encodes the trifunctional enzyme methylenetetrahydrofolate dehydrogenase involved in the pigmentation of pteridines and ommochromes; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. (968 aa) |
| | TTLL15 | Tubulin tyrosine ligase-like 15; ATP binding; protein-glycine ligase activity. It is involved in the biological process described with: protein polyglycylation. (516 aa) |
| | DNAlig3 | DNA ligase 3 (DNAlig3) encodes an ATP-dependent DNA ligase that is involved in the repair of nuclear and mitochondrial single- and double-strand DNA breaks. (806 aa) |
| | CG4830 | RE54693p; CoA-ligase activity; fatty acid ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (534 aa) |
| | GatA | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily. (508 aa) |
| | Scsalpha2 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (342 aa) |
| | CG11391 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (542 aa) |
| | CG11407 | GH20840p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (538 aa) |
| | CG11453 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (539 aa) |
| | CG11659 | RE32325p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (546 aa) |
| | CG6300 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (537 aa) |
| | AdSS | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. (447 aa) |
| | e | LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity. (879 aa) |
| | GluProRS | Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family. (1714 aa) |
| | CG6178 | GM05240p; CoA-ligase activity; long-chain fatty acid-CoA ligase activity; fatty acid ligase activity; fatty-acyl-CoA synthase activity. It is involved in the biological process described with: long-chain fatty acid metabolic process; fatty-acyl-CoA biosynthetic process; fatty acid biosynthetic process; acyl-CoA metabolic process. (544 aa) |
| | GatB | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). (516 aa) |
| | beta-PheRS | Phenylalanyl-tRNA synthetase, beta-subunit (beta-PheRS) encodes a cytoplasmic aminoacyl-tRNA synthetase that catalyzes the ligation of Phenylalanine to its cognate tRNAPhe. Together with the alpha-subunit it forms a tetrameric enzyme complex. This subunit plays a role in recognition and binding of tRNAPhe and it provides the editing site that hydrolyzes wrongfully activated or ligated compounds. (589 aa) |
| | TTLL5 | Tubulin tyrosine ligase-like 5, isoform A; Protein-glycine ligase activity; tubulin-glutamic acid ligase activity; ATP binding; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; C-terminal protein amino acid modification; protein polyglycylation; protein polyglutamylation. (917 aa) |
| | GlnRS | Probable glutamine--tRNA ligase; glutamine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: dendrite morphogenesis; glutaminyl-tRNA aminoacylation. (778 aa) |
| | TTLL6B | Tubulin tyrosine ligase-like 6B; ATP binding; protein-glycine ligase activity; tubulin-glutamic acid ligase activity; tubulin binding. It is involved in the biological process described with: protein polyglutamylation; protein polyglycylation; microtubule cytoskeleton organization. (720 aa) |
| | Mccc2 | Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (By similarity). Vital for adult survival. (578 aa) |
| | MetRS | Methionyl-tRNA synthetase (MetRS) encodes an enzyme that catalyzes the covalent attachment of methionine to methionyl-tRNA, an essential first step of protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (1022 aa) |
| | AsnRS-m | Asparaginyl-tRNA synthetase, mitochondrial; ATP binding; nucleic acid binding; asparagine-tRNA ligase activity. It is involved in the biological process described with: asparaginyl-tRNA aminoacylation. (460 aa) |
| | CysRS | Cysteine--tRNA ligase, cytoplasmic; ATP binding; cysteine-tRNA ligase activity; tRNA binding. It is involved in the biological process described with: cysteinyl-tRNA aminoacylation. (741 aa) |
| | Uba3 | Nedd8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling. (450 aa) |
| | PheRS-m | Probable phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. (453 aa) |
| | CG8834 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (535 aa) |
| | PCB | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1197 aa) |
| | Uba1 | Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. (1191 aa) |
| | ACC | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. (2482 aa) |
| | TTLL12 | Tubulin tyrosine ligase-like 12; ATP binding; protein-glycine ligase activity. It is involved in the biological process described with: protein polyglycylation. (626 aa) |
| | Ubc10 | Ubiquitin-conjugating enzyme E2-18 kDa; Ubiquitin-conjugating enzyme E2 that acts with the RBR family ligases LUBEL, ari-1 and possibly parkin. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Appears to be involved in the selective degradation of short-lived and abnormal proteins. Functions with ari-1 to control the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the [...] (154 aa) |
| | Aasdh | Beta-alanine-activating enzyme; Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post- translational protein modification or for post-transcriptional modification of an RNA. (1012 aa) |
| | r | Glutamine-dependent carbamoyl-phosphate synthase; Rudimentary (r) encodes the CAD protein that catalyzes the initial steps of de novo pyrimidine biosynthesis. r depletion results in wing malformations and pyrimidine auxotrophy. (2224 aa) |
| | GatC | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). (148 aa) |
| | AsnS | Asparagine synthase (glutamine-hydrolyzing) activity. It is involved in the biological process described with: asparagine biosynthetic process. (558 aa) |
| | AlaRS | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (966 aa) |
| | Mthfs | 5-formyltetrahydrofolate cyclo-ligase activity. It is involved in the biological process described with: tetrahydrofolate interconversion; folic acid-containing compound biosynthetic process. (201 aa) |
| | TTLL3B | Tubulin glycylase 3B; Essential glycylase which modifies both tubulin and non- tubulin proteins, generating side chains of glycine on the gamma- carboxyl groups of specific glutamate residues of target proteins. Monoglycylates alpha-tubulin by adding a single glycine chain to generate monoglycine side chains, but is not involved in elongation step to generate polyglycine side chains on alpha-tubulin. Has the ability to both mono- and polyglycylate non-tubulin proteins such as up (Troponin T). Required for early steps of spermatogenesis. (756 aa) |
| | TTLL4A | Tubulin tyrosine ligase-like 4A, isoform D; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity; tubulin binding. It is involved in the biological process described with: protein polyglutamylation; microtubule cytoskeleton organization; protein polyglycylation; wound healing. (1071 aa) |
| | TTLL6A | Tubulin tyrosine ligase-like 6A; Tubulin-glutamic acid ligase activity; protein-glycine ligase activity; ATP binding; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; protein polyglycylation; protein polyglutamylation. (867 aa) |
| | Gss1 | Glutathione synthetase 1 (Gss1) encodes an enzyme that catalyses the production of the cellular antioxidant glutathione by the condensation of gamma-glutamylcysteine and glycine. It is involved in cellular oxidative stress responses. (562 aa) |
| | ScsbetaA | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (503 aa) |
| | IleRS-m | Isoleucyl-tRNA synthetase, mitochondrial; tRNA binding; aminoacyl-tRNA editing activity; ATP binding; isoleucine-tRNA ligase activity. It is involved in the biological process described with: isoleucyl-tRNA aminoacylation; mitochondrial translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (941 aa) |
| | pdgy | Pudgy, isoform A; Pudgy (pdgy) encodes an acyl-CoA synthetase that activates fatty acids by conjugating them to CoA. It is a FOXO transcriptional target that preferentially activates fatty acids destined for beta-oxidation. (597 aa) |
| | Mccc1 | Methylcrotonoyl-CoA carboxylase 1 (Mccc1) encodes the biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase. It catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. (698 aa) |
| | Ppcs | Phosphopantothenoylcysteine synthetase, isoform C; Phosphopantothenate--cysteine ligase activity. (373 aa) |
| | AspRS-m | Aspartyl-tRNA synthetase, mitochondrial (AspRS-m) encodes a protein predicted to function within mitochondria to catalyze the ligation of aspartate to its cognate tRNA to form aspartyl-tRNA. (1082 aa) |
| | AsnRS | Asparaginyl-tRNA synthetase, isoform A; Nucleic acid binding; asparagine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: asparaginyl-tRNA aminoacylation. (558 aa) |
| | AspRS | Aspartyl-tRNA synthetase (AspRS) is an essential gene that is predicted to encode an aspartate-tRNA ligase. It functions as a Sxl dosage-sensitive maternal modifier. (531 aa) |
| | Acsl | Acyl-CoA synthetase long-chain, isoform J; Long-chain fatty acid-CoA ligase activity; palmitoyl-CoA ligase activity. (728 aa) |
| | ValRS | Valyl-tRNA synthetase, isoform C; aminoacyl-tRNA editing activity; ATP binding; valine-tRNA ligase activity. It is involved in the biological process described with: tRNA aminoacylation for protein translation; valyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (1055 aa) |
| | HisRS | Histidyl-tRNA synthetase, isoform D; histidine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: histidyl-tRNA aminoacylation; mitochondrial translation. (564 aa) |
| | ArgRS-m | Arginyl-tRNA synthetase, mitochondrial, isoform A; ATP binding; arginine-tRNA ligase activity. It is involved in the biological process described with: arginyl-tRNA aminoacylation; mitochondrial translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (594 aa) |
| | SerRS-m | Seryl-tRNA synthetase, mitochondrial (SerRS-m) encodes an enzyme that catalyses the aminoacylation of tRNAser with serine, to be used for gene translation during protein synthesis. (417 aa) |
| | Gclm | Glutamate-cysteine ligase modifier subunit (Gclm) encodes a protein that regulates the ligase activity of the product of Gclc. It is involved in glutathione biosynthesis, arsenic detoxification and response to ethanol. (285 aa) |
| | TTLL4B | Tubulin tyrosine ligase-like 4B, isoform B; ATP binding; protein-glycine ligase activity; tubulin-glutamic acid ligase activity; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; protein polyglycylation; protein polyglutamylation. (989 aa) |
| | Ass | ATP binding; argininosuccinate synthase activity. It is involved in the biological process described with: arginine biosynthetic process; argininosuccinate metabolic process; urea cycle; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (419 aa) |
| | Fatp2 | Long-chain fatty acid-CoA ligase activity; fatty acid transmembrane transporter activity; long-chain fatty acid transporter activity; very long-chain fatty acid-CoA ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process; fatty acid transport; triglyceride homeostasis. (714 aa) |
| | Gart | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. (1353 aa) |
| | CG1578 | LD05643p; Diphthine-ammonia ligase activity. It is involved in the biological process described with: peptidyl-diphthamide biosynthetic process from peptidyl-histidine. (901 aa) |
| | CysRS-m | Cysteinyl-tRNA synthetase, mitochondrial, isoform A; ATP binding; cysteine-tRNA ligase activity. It is involved in the biological process described with: cysteinyl-tRNA aminoacylation. (558 aa) |
| | Gclc | Glutamate-cysteine ligase catalytic subunit (Gclc) encodes a heterodimeric enzyme involved in the first rate-limiting step of glutathione synthesis. It binds L-cysteine and L-glutamate to form gamma-glutamylcysteine; Belongs to the glutamate--cysteine ligase type 3 family. (717 aa) |
| | CG8097 | RE16047p; arginine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: arginyl-tRNA aminoacylation. (446 aa) |
| | Gs2 | Glutamine synthetase 2 (Gs2) encodes an enzyme that converts glutamate to glutamine. It is expressed in the embryonic nervous system and regulates the size of glutamate neurotransmitter pools and synapse assembly. (373 aa) |
| | bur | Burgundy, isoform B; Burgundy (bur) encodes a GMP synthetase required for axon guidance. It regulates the activity of the ubiquitin protease encoded by Usp7. (683 aa) |
| | Hcs | Holocarboxylase synthetase (Hcs) encodes a biotin protein ligase that contributes to gluconeogenesis, fatty acid synthesis and amino acid catabolism. (1047 aa) |
| | LeuRS | Leucyl-tRNA synthetase, isoform A; leucine-tRNA ligase activity; ATP binding; aminoacyl-tRNA editing activity. It is involved in the biological process described with: leucyl-tRNA aminoacylation; wound healing; Belongs to the class-I aminoacyl-tRNA synthetase family. (1182 aa) |
| | CTPsyn | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Isoform 1 is required for cytoophidium assembly in female germline cells. (627 aa) |
| | CG6432 | GH15945p; Catalytic activity; short-chain fatty acid-CoA ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (674 aa) |
| | ThrRS | Threonyl-tRNA synthetase, isoform A; threonine-tRNA ligase activity; aminoacyl-tRNA ligase activity; ATP binding. It is involved in the biological process described with: tRNA aminoacylation for protein translation; threonyl-tRNA aminoacylation. (747 aa) |
| | ValRS-m | Valyl-tRNA synthetase, mitochondrial, isoform A; valine-tRNA ligase activity; aminoacyl-tRNA editing activity; ATP binding. It is involved in the biological process described with: tRNA aminoacylation for protein translation; valyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (994 aa) |
| | MetRS-m | Methionine--tRNA ligase, mitochondrial; ATP binding; methionine-tRNA ligase activity. It is involved in the biological process described with: methionyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (582 aa) |
| | Fatp1 | Fatty acid transport protein 1 (Fatp1) encodes a transmembrane protein with acyl-CoA synthetase activity required for photoreceptor survival. It is involved in the cellular uptake of long-chain fatty acids with a role in the catabolism of fatty acids as well as synthesis of triglycerides. (746 aa) |
