STRINGSTRING
CG6753 CG6753 CG18302 CG18302 Lip2 Lip2 Lip1 Lip1 zuc zuc CG18530 CG18530 Plc21C Plc21C CG11406 CG11406 CG11598 CG11598 Pld Pld CG3635 CG3635 bmm bmm norpA norpA mag mag CG11600 CG11600 CG11608 CG11608 lama lama CG8093 CG8093 Lip3 Lip3 CG31091 CG31091 Seipin Seipin sws sws dob dob sl sl iPLA2-VIA iPLA2-VIA CG2772 CG2772 CG31089 CG31089 Hnf4 Hnf4 CG18301 CG18301
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CG6753Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (405 aa)
CG18302Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (406 aa)
Lip2Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (413 aa)
Lip1Lipase 1; Could be a digestive enzyme; Belongs to the AB hydrolase superfamily. Lipase family. (439 aa)
zucMitochondrial cardiolipin hydrolase; Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes compose [...] (253 aa)
CG18530Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (389 aa)
Plc21C1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1318 aa)
CG11406Lipase; Hydrolase activity, acting on ester bonds; Belongs to the AB hydrolase superfamily. Lipase family. (396 aa)
CG11598Lipase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: multicellular organism reproduction; lipid metabolic process. (388 aa)
PldPhospholipase; Phosphatidylinositol binding; phospholipase D activity. (1364 aa)
CG3635Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (425 aa)
bmmBrummer, isoform B; Brummer (bmm) encodes a triglyceride lipase involved in glycerolipid metabolism, regulation of lipid storage and triglyceride homeostasis. (553 aa)
norpA1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] (1095 aa)
magLipase; Magro (mag) encodes a lipase induced by the product of Hr96 in the intestine, where it acts in the lumen to degrade dietary triglycerides for fatty acid absorption. (399 aa)
CG11600Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (406 aa)
CG11608Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; multicellular organism reproduction; Belongs to the AB hydrolase superfamily. Lipase family. (430 aa)
lamaPutative phospholipase B-like lamina ancestor; Putative phospholipase (By similarity). Involved in the regulation of cellular plasticity in imaginal disks. (658 aa)
CG8093Lipase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: multicellular organism reproduction; lipid metabolic process. (398 aa)
Lip3Lipase 3; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (394 aa)
CG31091Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (424 aa)
SeipinSeipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis. (370 aa)
swsNeuropathy target esterase sws; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain; Belongs to the NTE family. (1425 aa)
dobDoppelganger von brummer; Triglyceride lipase activity. It is involved in the biological process described with: lipid homeostasis; triglyceride catabolic process. (480 aa)
sl1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Small wing (sl) encodes a phosphatidylinositol-specific phospholiase type C that is required as a general modulator for growth downstream of the insulin pathway, and interacts with the Ras-MAPK pathway. (1236 aa)
iPLA2-VIACalcium-independent phospholipase A2 VIA (iPLA2-VIA) encodes a protein that localizes to cytosol and mitochondria involved in repairing oxidized mitochondrial lipids, such as cardiolipin, and thus preventing cytochrome c release. It is partially responsible for cardiolipin depletion and monolysocardiolipin accumulation in Taz-deficient flies, which is a model of Barth syndrome. (887 aa)
CG2772Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (416 aa)
CG31089Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (421 aa)
Hnf4Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. (732 aa)
CG18301Lipase; Hydrolase activity, acting on ester bonds; Belongs to the AB hydrolase superfamily. Lipase family. (422 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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