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| | Cchl | Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (281 aa) |
| | AlkB | AlkB, isoform A; Methylcytosine dioxygenase activity; class I DNA-(apurinic or apyrimidinic site) endonuclease activity. It is involved in the biological process described with: oxidation-reduction process. (332 aa) |
| | Pal2 | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2; Probable lyase that catalyzes an essential reaction in C- terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. (406 aa) |
| | mAcon1 | Aconitate hydratase, mitochondrial; Mitochondrial aconitase 1 (mAcon1) encodes an enzyme that harbors an iron-sulfur cluster and catalyses the first step of the Krebs Cycle in mitochondria, converting citrate into isocitrate; Belongs to the aconitase/IPM isomerase family. (787 aa) |
| | Mvd | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (388 aa) |
| | CG31183 | ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: protein phosphorylation; receptor guanylyl cyclase signaling pathway; cGMP-mediated signaling; signal transduction; cGMP biosynthetic process. (1417 aa) |
| | CAH3 | Carbonic anhydrase 3, isoform A; Zinc ion binding; carbonate dehydratase activity; hydro-lyase activity. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (250 aa) |
| | Hdc | Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family. (847 aa) |
| | Eip55E | Ecdysone-induced protein 55E (Eip55E) encodes a protein involved in glutathione biosynthesis. (393 aa) |
| | Ssl2 | Strictosidine synthase-like 2; Arylesterase activity; strictosidine synthase activity. It is involved in the biological process described with: biosynthetic process. (414 aa) |
| | CAH7 | Carbonic anhydrase 7, isoform A; Zinc ion binding; hydro-lyase activity; carbonate dehydratase activity. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (304 aa) |
| | CAH16 | Carbonic anhydrase 16, isoform C; Carbonate dehydratase activity; hydro-lyase activity; zinc ion binding. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (286 aa) |
| | Hmgcl | 3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform A; hydroxymethylglutaryl-CoA lyase activity. It is involved in the biological process described with: leucine metabolic process; leucine catabolic process; lipid metabolic process; ketone body biosynthetic process. (323 aa) |
| | CARPA | Carbonic anhydrase-related protein A, isoform B; Hydro-lyase activity; carbonate dehydratase activity; zinc ion binding. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (333 aa) |
| | Ppcdc | Phosphopantothenoylcysteine decarboxylase activity. It is involved in the biological process described with: coenzyme A biosynthetic process. (191 aa) |
| | CAH8 | Carbonic anhydrase 8, isoform A; Carbonate dehydratase activity; hydro-lyase activity; zinc ion binding. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (303 aa) |
| | CARPB | Carbonic anhydrase-related protein B, isoform A; Hydro-lyase activity; carbonate dehydratase activity; zinc ion binding. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (327 aa) |
| | CAH14 | Carbonic anhydrase 14; Carbonate dehydratase activity; hydro-lyase activity; zinc ion binding. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (295 aa) |
| | RpLP0 | 60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10; Belongs to the universal ribosomal protein uL10 family. (317 aa) |
| | Uros1 | uroporphyrinogen-III synthase activity. It is involved in the biological process described with: heme biosynthetic process; uroporphyrinogen III biosynthetic process. (277 aa) |
| | Pbgs | Delta-aminolevulinic acid dehydratase; Zinc ion binding; porphobilinogen synthase activity. It is involved in the biological process described with: heme biosynthetic process; Belongs to the ALAD family. (327 aa) |
| | CG4598 | RH73277p; enoyl-CoA hydratase activity; dodecenoyl-CoA delta-isomerase activity. It is involved in the biological process described with: fatty acid beta-oxidation. (281 aa) |
| | Ac13E | Adenylyl cyclase 13E, isoform C; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1703 aa) |
| | Fum3 | Fumarase 3, isoform A; Fumarate hydratase activity. It is involved in the biological process described with: fumarate metabolic process; malate metabolic process; tricarboxylic acid cycle. (470 aa) |
| | CG11134 | Probable methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (227 aa) |
| | CG4592 | FI09311p; dodecenoyl-CoA delta-isomerase activity; enoyl-CoA hydratase activity. It is involved in the biological process described with: fatty acid beta-oxidation. (287 aa) |
| | CG4594 | LD18769p; enoyl-CoA hydratase activity; dodecenoyl-CoA delta-isomerase activity. It is involved in the biological process described with: fatty acid beta-oxidation. (280 aa) |
| | CG10747 | FI02810p; Phosphoric diester hydrolase activity; glycosylphosphatidylinositol diacylglycerol-lyase activity. It is involved in the biological process described with: glycerophospholipid metabolic process. (328 aa) |
| | Ac78C | Adenylyl cyclase 78C; [Isoform B]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein coupled receptor signaling. Probably downstream of gustatory receptors, involved in taste perception of sucrose, trehalose and caffeine. Has no role in bitter perception. In the circadian brain neuron evening cells (E- cells), involved in circadian pacemaker synchronization by playing a role in signaling downstream of the G protein-coupled receptor Pdfr, probably in conjunction with other, as yet unidentified, adenylate cyclases. (1727 aa) |
| | ACXE | Adenylyl cyclase X E; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1123 aa) |
| | b | Black (b) encodes an aspartate 1-decarboxylase. Mutations of b result in viable flies with a cuticular melanization phenotype. (575 aa) |
| | CG43373 | Uncharacterized protein, isoform C; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process. (1854 aa) |
| | CAH5 | Carbonic anhydrase 5; Hydro-lyase activity; carbonate dehydratase activity; zinc ion binding. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (302 aa) |
| | Ac76E | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1312 aa) |
| | CG10738 | Guanylate cyclase activity; peptide receptor activity; ATP binding; signaling receptor activity. (1250 aa) |
| | Tsen34 | tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (276 aa) |
| | CG42637 | Receptor-type guanylate cyclase Gyc76C; Guanylate cyclase involved in the production of the second messenger cGMP. Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity. Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscl [...] (1525 aa) |
| | CG32305 | Uncharacterized protein; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1164 aa) |
| | CG32301 | Uncharacterized protein, isoform C; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-activating G protein-coupled receptor signaling pathway; chaeta development; notum development; cyclic nucleotide biosynthetic process. (1111 aa) |
| | CG42514 | GH08173p; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport. (533 aa) |
| | ATPCL | ATP-citrate synthase; ATP citrate lyase (ATPCL) encodes a protein involved in glucose homeostasis; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1112 aa) |
| | Argl | Argininosuccinate lyase activity. It is involved in the biological process described with: arginine biosynthetic process via ornithine. (469 aa) |
| | Rrp1 | Recombination repair protein 1; Plays a role in the cellular response to oxidative stress by promoting DNA repair mechanisms such as base excision repair and possibly homologous recombination repair. Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Likely to initiate repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydrox [...] (706 aa) |
| | Tsen2 | Uncharacterized protein; tRNA-intron endonuclease activity; nucleic acid binding. It is involved in the biological process described with: tRNA-type intron splice site recognition and cleavage. (233 aa) |
| | CG32196 | IP08408p; Gamma-glutamylcyclotransferase activity. (195 aa) |
| | CG3216 | Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP biosynthetic process; signal transduction; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP-mediated signaling. (1161 aa) |
| | CAH6 | Carbonic anhydrase 6; Hydro-lyase activity; carbonate dehydratase activity; zinc ion binding. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (298 aa) |
| | CG6171 | Aprataxin and PNK-like factor; Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. (255 aa) |
| | Gyc32E | ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: cGMP biosynthetic process; signal transduction; cGMP-mediated signaling; receptor guanylyl cyclase signaling pathway; protein phosphorylation. (1191 aa) |
| | Gyc89Da | Soluble guanylate cyclase 89Da; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (667 aa) |
| | Gyc88E | Soluble guanylate cyclase 88E; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (1097 aa) |
| | GstD1 | Glutathione S-transferase D1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification. (209 aa) |
| | CG33958 | FI12009p; Peptide receptor activity; guanylate cyclase activity. It is involved in the biological process described with: receptor guanylyl cyclase signaling pathway; cGMP biosynthetic process; signal transduction; intracellular signal transduction. (710 aa) |
| | CG9272 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (388 aa) |
| | CG18853 | TA01342p; tRNA (adenine-N6-)-methyltransferase activity. (330 aa) |
| | pr | 6-pyruvoyl tetrahydrobiopterin synthase; Required for pigment and biopterin synthesis. Belongs to the PTPS family. (168 aa) |
| | Glo1 | Glyoxalase 1; Lactoylglutathione lyase activity; metal ion binding. It is involved in the biological process described with: regulation of insulin receptor signaling pathway. (176 aa) |
| | Odc2 | Ornithine decarboxylase 2; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. (393 aa) |
| | Odc1 | Ornithine decarboxylase 1; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. (394 aa) |
| | phr | Photorepair, isoform A; Photorepair (phr) encodes a DNA photolyase apoenzyme that repairs UV-induced DNA damage using FAD as a cofactor and blue light as a co-substrate. (555 aa) |
| | Tsen15 | Uncharacterized protein, isoform A; tRNA-intron endonuclease activity. It is involved in the biological process described with: tRNA splicing, via endonucleolytic cleavage and ligation. (170 aa) |
| | Urod | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (356 aa) |
| | Pal1 | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 1; Probable lyase that catalyzes an essential reaction in C- terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. (541 aa) |
| | CAH13 | Carbonic anhydrase 13; Hydro-lyase activity; carbonate dehydratase activity; zinc ion binding. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (527 aa) |
| | Dera | Deoxyribose-phosphate aldolase activity. It is involved in the biological process described with: carbohydrate catabolic process; deoxyribonucleotide catabolic process. (347 aa) |
| | CG8778 | SD19268p; enoyl-CoA hydratase activity. It is involved in the biological process described with: fatty acid beta-oxidation; cold acclimation; Belongs to the enoyl-CoA hydratase/isomerase family. (299 aa) |
| | Echs1 | Enoyl-CoA hydratase, short chain 1, isoform A; enoyl-CoA hydratase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the enoyl-CoA hydratase/isomerase family. (295 aa) |
| | Sply | Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily. (545 aa) |
| | Pepck1 | Phosphoenolpyruvate carboxykinase 1 (Pepck1) encodes an enzyme that converts oxaloacetate into phosphoenolpyruvate. It catalyzes the first committed step in gluconeogenesis and thus plays an essential role in glucose metabolism. (647 aa) |
| | Pepck2 | Phosphoenolpyruvate carboxykinase (GTP) activity; manganese ion binding; GTP binding. (638 aa) |
| | Hacl | Magnesium ion binding; carbon-carbon lyase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: fatty acid alpha-oxidation; Belongs to the TPP enzyme family. (568 aa) |
| | Tdc1 | Tyrosine decarboxylase 1 (Tdc1) encodes a protein involved in behavioral response to ethanol. (587 aa) |
| | Tdc2 | Tyrosine decarboxylase activity; carboxy-lyase activity; pyridoxal phosphate binding. It is involved in the biological process described with: oviposition; locomotor rhythm; behavioral response to cocaine; cellular amino acid metabolic process; locomotory behavior. (637 aa) |
| | Ac3 | Adenylate cyclase 3 (Ac3) encodes an adenylate cyclase that is coupled to the receptor encoded by Pdfr via Gs signaling in the Morning circadian pacemakers. (1167 aa) |
| | FeCH | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (384 aa) |
| | Gycbeta100B | Guanylyl cyclase beta-subunit at 100B (Gycbeta100B) encodes an enzyme that synthesizes cyclic GMP and is activated by nitric oxide; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (787 aa) |
| | Pcd | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process. (192 aa) |
| | Gycalpha99B | Head-specific guanylate cyclase; Guanylyl cyclase alpha-subunit at 99B (Gycalpha99B) encodes a guanylate cyclase involved in cyclic GMP biosynthesis and phototaxis mediated by rhodopsin. (676 aa) |
| | Hmu | FI18644p1; Arylesterase activity; strictosidine synthase activity. It is involved in the biological process described with: biosynthetic process. (579 aa) |
| | CAH9 | Carbonic anhydrase 9; Carbonate dehydratase activity; hydro-lyase activity; zinc ion binding. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (311 aa) |
| | Ald2 | Fructose-bisphosphate aldolase activity. It is involved in the biological process described with: fructose 1,6-bisphosphate metabolic process; glycolytic process. (364 aa) |
| | Ald1 | Fructose-bisphosphate aldolase; May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases). (363 aa) |
| | CAH4 | Carbonic anhydrase 4, isoform A; Zinc ion binding; hydro-lyase activity; carbonate dehydratase activity. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (279 aa) |
| | Pisd | Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily. (447 aa) |
| | CG10184 | LD34157p; L-allo-threonine aldolase activity. It is involved in the biological process described with: threonine catabolic process; glycine biosynthetic process. (383 aa) |
| | CG10365 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (284 aa) |
| | Irp-1A | Iron regulatory protein 1A (Irp-1A) encodes a cytosolic aconitase that under iron deficiency (or if cytosolic superoxide is present) loses its iron-sulfur cluster, changes confirmation and binds iron regulatory elements (so far identified on the products of SdhB and Fer1HCH mRNAs); Belongs to the aconitase/IPM isomerase family. (902 aa) |
| | CG34357 | Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP-mediated signaling; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP biosynthetic process; signal transduction. (1689 aa) |
| | r-l | Orotidine 5'-phosphate decarboxylase; Rudimentary-like (r-l) encodes an enzyme involved in the novo pyrimidine biosynthesis; In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (493 aa) |
| | AdSL | Adenylosuccinate Lyase (AdSL) encodes a protein that might be a lyase involved in purine nucleotide metabolic process based on orthology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa) |
| | Gyc89Db | Soluble guanylate cyclase 89Db; Heterodimers with Gyc88E are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (669 aa) |
| | Uros2 | uroporphyrinogen-III synthase activity. It is involved in the biological process described with: heme biosynthetic process; uroporphyrinogen III biosynthetic process. (253 aa) |
| | Kyat | Kynurenine aminotransferase, isoform A; Pyridoxal phosphate binding; cysteine-S-conjugate beta-lyase activity; kynurenine-oxoglutarate transaminase activity. It is involved in the biological process described with: biosynthetic process; kynurenine metabolic process. (450 aa) |
| | mAcon2 | Aconitate hydratase, mitochondrial; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity. It is involved in the biological process described with: tricarboxylic acid cycle; multicellular organism reproduction; Belongs to the aconitase/IPM isomerase family. (783 aa) |
| | Irp-1B | Iron regulatory protein 1B (Irp-1B) encodes a cytosolic aconitase highly homologous to the product of Irp-1A; Belongs to the aconitase/IPM isomerase family. (899 aa) |
| | Srr | Serine racemase, isoform B; Serine racemase activity; L-serine ammonia-lyase activity; L-threonine ammonia-lyase activity. It is involved in the biological process described with: threonine catabolic process; L-serine catabolic process. (469 aa) |
| | CAHbeta | Carbonic anhydrase beta (CAHbeta) encodes a beta-class carbonate dehydratase that catalyzes the reversible hydration/dehydration of carbon dioxide to bicarbonate and protons. (255 aa) |
| | phr6-4 | (6-4)-photolyase, isoform A; (6-4)-photolyase (phr6-4) encodes an enzyme that repairs DNA damage induced by ultraviolet light. It uses blue light and cofactor FADH to reverse the pyrimidine(6-4)pyrimidone photoproduct. (540 aa) |
| | Ddc | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. (510 aa) |
| | amd | 3,4-dihydroxyphenylacetaldehyde synthase; Catalyzes both the decarboxylation and deamination of L-dopa to 3,4-dihydroxylphenylacetaldehyde (DHPAA). Probably responsible for the protein cross-linking during the development of flexible cuticles. Participates in catecholamine catabolism. (510 aa) |
| | CAH1 | Carbonic anhydrase 1 (CAH1) encodes an alpha-class carbonate dehydratase that catalyzes the reversible hydration/dehydration of carbon dioxide to bicarbonate and protons. (270 aa) |
| | Hacd2 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (371 aa) |
| | ACXA | Adenylyl cyclase X A, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-activating G protein-coupled receptor signaling pathway; cyclic nucleotide biosynthetic process; spermatogenesis. (1112 aa) |
| | ACXB | Adenylyl cyclase X B; Adenylate cyclase activity. It is involved in the biological process described with: spermatogenesis; cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1114 aa) |
| | ACXC | Adenylyl cyclase X C, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; spermatogenesis; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1130 aa) |
| | Hacd1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (245 aa) |
| | PLCXD | Uncharacterized protein, isoform A; Glycosylphosphatidylinositol diacylglycerol-lyase activity; phosphoric diester hydrolase activity. It is involved in the biological process described with: glycerophospholipid metabolic process. (482 aa) |
| | SamDC | S-adenosylmethionine decarboxylase (SamDC) encodes a protein involved in defense response to Gram-negative bacterium; Belongs to the eukaryotic AdoMetDC family. (347 aa) |
| | Fum4 | Fumarase 4; Fumarate hydratase activity. It is involved in the biological process described with: fumarate metabolic process; malate metabolic process; tricarboxylic acid cycle. (484 aa) |
| | Mtpalpha | Mitochondrial trifunctional protein alpha subunit (Mtpalpha) encodes a subunit of the mitochondrial trifunctional protein. It possesses 3-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities, which catalyze the second and third steps,respectively, of the beta-oxidation of long-chain fatty acids. (783 aa) |
| | Gmd | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (395 aa) |
| | HIPP1 | HP1 and insulator partner protein 1 (HIPP1) encodes a chromatin-associated protein, displaying strong protein-protein interaction with the product of Su(var)205. It is localized to pericentric heterochromatin, and potentially has a separate role bound to insulators along with the products of su(Hw), mod(mdg4) and Cp190. (926 aa) |
| | CG5618 | LP10922p; Pyridoxal phosphate binding; glutamate decarboxylase activity. It is involved in the biological process described with: carboxylic acid metabolic process. (510 aa) |
| | Eno | Enolase (Eno) encodes a phosphopyruvate hydratase involved in glucose homeostasis; Belongs to the enolase family. (500 aa) |
| | Cbs | Cystathionine beta-synthase (Cbs) encodes an enzyme involved in endoplasmic reticulum stress response; Belongs to the cysteine synthase/cystathionine beta- synthase family. (522 aa) |
| | CG1486 | GH01474p; Pyridoxal phosphate binding; carboxy-lyase activity; sphinganine-1-phosphate aldolase activity. It is involved in the biological process described with: sphingolipid metabolic process; sphingolipid catabolic process; ameboidal-type cell migration; carboxylic acid metabolic process. (852 aa) |
| | Uxs | UDP-xylose synthase; NAD+ binding; UDP-glucuronate decarboxylase activity. (441 aa) |
| | Mocs1 | Cyclic pyranopterin monophosphate synthase; Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)- 3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'- triphosphate to cPMP; In the C-terminal section; belongs to the MoaC family. (565 aa) |
| | CAH2 | Carbonic anhydrase 2 (CAH2) encodes an alpha-class carbonate dehydratase that catalyzes the reversible hydration/dehydration of carbon dioxide to bicarbonate and protons. (335 aa) |
| | CG8745 | Alanine--glyoxylate aminotransferase 2-like; Ethanolamine-phosphate phospho-lyase activity; transaminase activity; pyridoxal phosphate binding. It is involved in the biological process described with: response to nicotine. (494 aa) |
| | CG4306 | RE30433p; Gamma-glutamylcyclotransferase activity. (220 aa) |
| | Naxd | ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (300 aa) |
| | Mfe2 | Peroxisomal Multifunctional enzyme type 2 (Mfe2) encodes a multifunctional protein harboring two separate enzyme activities: 2-enoyl-CoA hydratase 2 and 3-hydroxyacyl-CoA dehydrogenase. They function in the peroxisomal fatty acid breakdown spiral of beta-oxidation utilizing the (R)-isomer of the CoA-containing substrate; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (598 aa) |
| | rut | Ca(2+)/calmodulin-responsive adenylate cyclase; Rutabaga (rut) encodes a membrane-bound Ca[2+]/calmodulin-activated adenylyl cyclase that is responsible for synthesis of cAMP. It plays a key role in regulating behavioral, neuroanatomical, and electrophysiological plasticity. (2248 aa) |
| | Paics | Phosphoribosylaminoimidazole-succinocarboxamide synthase; PAICS bifunctional enzyme (Paics) encodes an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the N-terminal section; belongs to the SAICAR synthetase family. (429 aa) |
| | CG2540 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (311 aa) |
| | Gad1 | Glutamic acid decarboxylase 1 (Gad1) encodes an essential, nervous system-specific glutamic acid decarboxylase, which is the synthetic enzyme for the major inhibitory neurotransmitter gamma-Aminobutyric acid (GABA). It is required for a multitude of physiological functions and adult behaviors dependent on GABA, including sleep, memory, circadian rhythms and egg hatching; Belongs to the group II decarboxylase family. (510 aa) |
| | ACXD | Adenylyl cyclase X D, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1162 aa) |
| | GC | Gamma-glutamyl carboxylase (GC) encodes an enzyme involved in peptidyl-glutamic acid carboxylation. (672 aa) |
| | Mtpbeta | GH13256p; Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family. (469 aa) |
| | CAH15 | Carbonic anhydrase 15; Zinc ion binding; hydro-lyase activity; carbonate dehydratase activity. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family. (332 aa) |
| | Ogg1 | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Efficiently incises DNA duplexes containing 8-hydroxyguanine (8-OH-Gua), 8-hydroxyadenine (8- OH-Ade) and abasic (AP) sites placed opposite to a cytosine. (343 aa) |
| | Fum2 | Fumarase 2; Fumarate hydratase activity. It is involved in the biological process described with: tricarboxylic acid cycle; malate metabolic process; fumarate metabolic process. (503 aa) |
| | Fum1 | Fumarase 1, isoform A; Fumarate hydratase activity. It is involved in the biological process described with: fumarate metabolic process; tricarboxylic acid cycle. (495 aa) |
