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| | Ublcp1 | Ubiquitin-like domain-containing C-terminal domain phosphatase 1 (Ublcp1) encodes a nuclear HAD family phospho-Ser/Thr phosphatase that binds and dephosphorylates the nuclear 26S proteasome and inhibits proteasome activity. (320 aa) |
| | Dcr-1 | Endoribonuclease Dcr-1; Essential for RNA interference (RNAi); double-stranded RNA (dsRNA) induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. May carry out the initiation step of RNAi by cleaving dsRNA to produce 22 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. During embryogenesis, involved in germline fate determination; Belongs to the helicase family. Dicer subfamily. (2249 aa) |
| | Trf4-2 | Inactive non-canonical poly(A) RNA polymerase protein Trf4-2; Polynucleotide adenylyltransferase activity. It is involved in the biological process described with: histone mRNA catabolic process; nuclear polyadenylation-dependent ncRNA catabolic process; snoRNA polyadenylation; Belongs to the DNA polymerase type-B-like family. (407 aa) |
| | CG5116 | FI04601p; Ribosome binding; GTP binding. (526 aa) |
| | CG6036 | Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade. (371 aa) |
| | ball | Nucleosomal histone kinase 1; Serine/threonine-protein kinase involved in somatic mitosis and female meiosis. Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis- specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle. Specifically phosphorylates nucleosomal H2A on 'Thr-119'. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Belongs to the protei [...] (599 aa) |
| | alph | Alphabet, isoform E; Alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling. (374 aa) |
| | fig | Protein phosphatase PTC7 homolog fig; Protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity. It is involved in the biological process described with: dephosphorylation; regulation of ubiquinone biosynthetic process; protein dephosphorylation. (314 aa) |
| | wts | Serine/threonine-protein kinase Warts; Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activi [...] (1105 aa) |
| | Alp4 | Alkaline phosphatase 4; Important role in neural and renal epithelial function. (596 aa) |
| | Ac3 | Adenylate cyclase 3 (Ac3) encodes an adenylate cyclase that is coupled to the receptor encoded by Pdfr via Gs signaling in the Morning circadian pacemakers. (1167 aa) |
| | CG10417 | Cation binding; protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation. (662 aa) |
| | Rab2 | Rab2, isoform A; Rab2 (Rab2) encodes a protein that belongs to the Rab family of small Ras-like GTPases that regulate vesicle trafficking. Rab2 product contributes to the maturation and fusion of endosomes and autophagosomes with lysosomes. (213 aa) |
| | mei-W68 | Meiotic W68 (mei-W68) encodes a protein thought to form a dimer with the TopoVIA subunit encoded by mei-P22 and is required for the formation of double strand breaks during meiosis. (331 aa) |
| | Fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (385 aa) |
| | RpI1 | DNA-directed RNA polymerase I subunit RPA1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation o [...] (1642 aa) |
| | Pfk | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (950 aa) |
| | Alp6 | Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (515 aa) |
| | CG1814 | FI20020p1; Single-stranded DNA binding; 5'-nucleotidase activity. It is involved in the biological process described with: cellular response to DNA damage stimulus. (548 aa) |
| | rnh1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (333 aa) |
| | tor | Tyrosine-protein kinase receptor torso; Probable receptor tyrosine kinase which is required for determination of anterior and posterior terminal structures in the embryo. During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone Ptth. Binding to Ptth stimulates activation of canonical MAPK signaling leading to ERK phosphorylation (By similarity). (923 aa) |
| | Orc1 | Origin recognition complex subunit 1 (Orc1) encodes the largest subunit of the origin recognition complex (ORC), which is essential for the initiation of DNA replication in eukaryotic cells. The ATPase activity of the product of Orc1 is critical for the formation and function of the pre-replicative complex. The regulated degradation of the product of Orc1 by ubiquitin-mediated proteolysis after initiation of DNA replication helps to prevent re-replication. (924 aa) |
| | Sam-S | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. (408 aa) |
| | r | Glutamine-dependent carbamoyl-phosphate synthase; Rudimentary (r) encodes the CAD protein that catalyzes the initial steps of de novo pyrimidine biosynthesis. r depletion results in wing malformations and pyrimidine auxotrophy. (2224 aa) |
| | CG33298 | Magnesium ion binding; ATP binding; ATPase-coupled intramembrane lipid transporter activity. It is involved in the biological process described with: phospholipid translocation; Golgi organization; intracellular protein transport; response to endoplasmic reticulum stress; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1517 aa) |
| | Galphao | G protein alpha o subunit (Galphao) encodes the most abundant G protein in the nervous tissue and is involved in signaling by a variety of GPCRs. It contributes to heart development, axonogenesis, neuro-muscular junction formation, asymmetric cell division, planar cell polarity, blood-brain barrier establishment, Wnt signaling, and gustatory and olfactory sensory perception; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (354 aa) |
| | mt:CoI | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (511 aa) |
| | mt:CoII | Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (228 aa) |
| | Gs1l | Probable pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. (231 aa) |
| | Gyc88E | Soluble guanylate cyclase 88E; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (1097 aa) |
| | Gyc89Da | Soluble guanylate cyclase 89Da; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (667 aa) |
| | Mthfs | 5-formyltetrahydrofolate cyclo-ligase activity. It is involved in the biological process described with: tetrahydrofolate interconversion; folic acid-containing compound biosynthetic process. (201 aa) |
| | cu | Nocturnin; Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Because of its association with the CCR4-NOT complex, has a role in mRNA deadenylation and decay. Required at the pupal stage for proper wing morphogenesis after eclosion. [Isoform D]: In dorsal neurons, contributes to the light- mediated behavioral response; Belongs to the CCR4/nocturin family. (642 aa) |
| | anne | Nucleotide binding; ATPase activity. It is involved in the biological process described with: cellular calcium ion homeostasis; cation transport; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1451 aa) |
| | Unc-89 | Obscurin; Structural component of the muscle M line which is involved in assembly and organization of sarcomere. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Likely to have serine/threonine-protein kinase activity as one of the two protein kinase domains appears to be functional (Probable). (4218 aa) |
| | Rrp1 | Recombination repair protein 1; Plays a role in the cellular response to oxidative stress by promoting DNA repair mechanisms such as base excision repair and possibly homologous recombination repair. Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Likely to initiate repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydrox [...] (706 aa) |
| | ATP8A | ATP binding; magnesium ion binding; ATPase-coupled intramembrane lipid transporter activity. It is involved in the biological process described with: phospholipid translocation; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1350 aa) |
| | ATP8B | ATPase 8B (ATP8B) encodes a phospholipid flippase involved in olfaction; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1726 aa) |
| | ATPCL | ATP-citrate synthase; ATP citrate lyase (ATPCL) encodes a protein involved in glucose homeostasis; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1112 aa) |
| | Gss1 | Glutathione synthetase 1 (Gss1) encodes an enzyme that catalyses the production of the cellular antioxidant glutathione by the condensation of gamma-glutamylcysteine and glycine. It is involved in cellular oxidative stress responses. (562 aa) |
| | ScsbetaA | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (503 aa) |
| | CG42637 | Receptor-type guanylate cyclase Gyc76C; Guanylate cyclase involved in the production of the second messenger cGMP. Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity. Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscl [...] (1525 aa) |
| | WRNexo | Werner Syndrome-like exonuclease; WRN exonuclease (WRNexo) encodes a 3'-5' exonuclease that cleaves 3' ends of both single-stranded and duplex DNA substrates that resemble DNA structures present during DNA replication. It may act in concert with RecQ family helicases to resolve Holliday junctions or other unusual DNA structures. It is likely to be involved in DNA replication, recombination and repair, and is essential for early embryonic development. (354 aa) |
| | Tao | Serine/threonine-protein kinase Tao; Serine/threonine-protein kinase which regulates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein. In imaginal cells, pho [...] (1039 aa) |
| | Prat | Amidophosphoribosyltransferase; Phosphoribosylamidotransferase (Prat) encodes a type-2 glutamine amidotransferase that converts phosphoribosylpyrophosphate to phosphoribosylamine using glutamine. It is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (546 aa) |
| | Ac76E | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1312 aa) |
| | CG9391 | Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol phosphorylation; inositol phosphate dephosphorylation; inositol metabolic process; signal transduction. (278 aa) |
| | Gld2 | GLD2 poly(A) polymerase (Gld2) encodes a conserved poly-A polymerase in the GLD2 family. It is a paralog of the wisp gene. Gld2 is expressed strongly in the testis and at low levels in other tissues including the nervous system. In the male germ line, the product of Gld2 is essential for postmeiotic development of sperm; its depletion causes arrest of spermatogenesis prior to individualization, with abnormal nuclear condensation phenotypes. In the brain it is required for long-term memory. (1364 aa) |
| | ACXE | Adenylyl cyclase X E; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1123 aa) |
| | Ac78C | Adenylyl cyclase 78C; [Isoform B]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein coupled receptor signaling. Probably downstream of gustatory receptors, involved in taste perception of sucrose, trehalose and caffeine. Has no role in bitter perception. In the circadian brain neuron evening cells (E- cells), involved in circadian pacemaker synchronization by playing a role in signaling downstream of the G protein-coupled receptor Pdfr, probably in conjunction with other, as yet unidentified, adenylate cyclases. (1727 aa) |
| | put | Serine/threonine-protein kinase receptor; Punt (put) encodes a transforming growth factor beta type II receptor that functions in both Dpp/BMP and Activin signaling. Pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with the product of put; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (520 aa) |
| | hrg | Hiiragi, isoform D; Hiiragi (hrg) encodes the canonical poly(A) polymerase required for the nuclear poly(A) tail synthesis at the mRNA 3'-end. hrg product is also involved in cytoplasmic polyadenylation of specific mRNAs during early to mid-oogenesis, through its interaction with the CPEB (cytoplasmic polyadenylation element binding) protein encoded by orb. (827 aa) |
| | PKD | Protein Kinase D (PKD) encodes a Ser/Thr kinase of the PKC family of Ca[2+]/calmodulin-dependent protein kinases. It regulates actin-dynamics by controlling the activity of the phosphatase encoded by ssh. (906 aa) |
| | Pde9 | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. (1623 aa) |
| | Fign | Fidgetin-like protein 1; ATP binding; magnesium ion binding; ATPase activity; microtubule-severing ATPase activity; hydrolase activity. (523 aa) |
| | Trf4-1 | Non-canonical poly(A) RNA polymerase protein Trf4-1; Involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Polyadenylates RNA processing and degradation intermediates of snRNAs and mRNAs. (1001 aa) |
| | trc | Serine/threonine-protein kinase tricorner; Has an important role, with fry, in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. Affects cellular morphogenesis by regulating the expression of target genes that encode cytoskeleton-interacting proteins and not via the direct modification of the cytoskeleton. Maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons. Belongs to the protein kinase supe [...] (463 aa) |
| | Top2 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. During meiosis, it disrupts heterochromatic connections between achiasmate and chiasmate homologs after spindle assembly so that chromosomes can separate at prometaphase I. During mitosis, it functions in the separation of sister chromatids by establishing amphitelic kinetochore attachments in mitotic spindles. May have a role in chromatin [...] (1447 aa) |
| | Wee1 | Wee1-like protein kinase; Wee1 kinase (Wee1) encodes a tyrosine kinase required for triggering entry into mitosis. The activity of the Wee1 product contributes to spindle assembly and alignment and separation of the chromosomes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (609 aa) |
| | JIL-1 | Chromosomal serine/threonine-protein kinase JIL-1; Phosphorylates 'Ser-10' of histone H3. May regulate gene expression by establishing or maintaining the structure of more open chromatin regions. Also required for normal polytene chromosome structure, for oogenesis and for viability throughout development. Regulates the structure of polytene chromosomes in salivary glands. May phosphorylate 'Ser-1' of histone H2A. (1207 aa) |
| | Idh | Isocitrate dehydrogenase (Idh) encodes a cytosolic enzyme that catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with Men, Zw, and Pgd, in a small network of NADP reducing enzymes. (479 aa) |
| | Galphaq | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. (396 aa) |
| | Tailor | Tailor (Tailor) encodes a cytoplasmic RNA-specific terminal uridylyltransferase. It acts as part of the terminal RNA uridylation-mediated processing (TRUMP) complex, marking RNA species for 3'-to-5' exoribonucleolytic decay by the product of Dis3l2. The product of Tailor regulates microRNA biogenesis by targeting precursor-microRNAs (predominantly mirtron hairpins) and targets unprocessed RNA polymerase III transcripts for degradation in a cytoplasmic RNA surveillance pathway. (563 aa) |
| | CG12091 | Protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity. It is involved in the biological process described with: protein dephosphorylation; Belongs to the PP2C family. (321 aa) |
| | CG17029 | Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: inositol metabolic process; signal transduction; inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation. (284 aa) |
| | CG17027 | Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: signal transduction; inositol metabolic process; inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation. (288 aa) |
| | CG17598 | GM14138p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding; [pyruvate dehydrogenase (lipoamide)] phosphatase activity. It is involved in the biological process described with: positive regulation of pyruvate dehydrogenase activity; dephosphorylation; protein dephosphorylation. (651 aa) |
| | CG9981 | ATPase-coupled intramembrane lipid transporter activity; magnesium ion binding; ATP binding. It is involved in the biological process described with: phospholipid translocation; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1060 aa) |
| | cta | Guanine nucleotide-binding protein subunit alpha homolog; May play a role in a signal transduction pathway used during gastrulation. Required specifically for the ventral furrow and posterior midgut invaginations, where it is necessary for coordinating cell shape changes; Belongs to the G-alpha family. G(12) subfamily. (457 aa) |
| | Idh3a | Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Magnesium ion binding; isocitrate dehydrogenase (NAD+) activity; NAD binding. It is involved in the biological process described with: tricarboxylic acid cycle; isocitrate metabolic process. (377 aa) |
| | Dyrk2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2; In vitro; can phosphorylate exogenous substrates on Ser and Thr residues. May have a physiological role in development being involved in cellular growth and differentiation. (757 aa) |
| | meng | Serine/threonine-protein kinase meng-po; Serine/threonine-protein kinase involved in memory formation. Together with the cAMP-dependent protein kinase A Pka-C1, promotes long-term memory (LTM) by regulating CrebB stability and activity. Involved in the maintenance of anesthesia-sensitive memory (ASM) which includes short-term memory (STM) and middle-term memory (MTM). (456 aa) |
| | DNApol-iota | DNA polymerase iota; Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site (By similarity). Inserts the correct base with higher fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity). (737 aa) |
| | CG32549 | Uncharacterized protein, isoform G; 5'-nucleotidase activity. (709 aa) |
| | wisp | Poly(A) RNA polymerase gld-2 homolog B; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific maternal RNAs (bcd, Tl, and tor), forming a poly(A) tail, during late oogenesis and early embryogenesis. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Required for localization of mRNAs to both poles of the egg, to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): the central MTOC that forms between the meiosis II tandem spindles and [...] (1373 aa) |
| | rdgC | Retinal degeneration C (rdgC) encodes a serine/threonine phosphatase that binds Ca2+/calmodulin and contains 2 Ca2+-binding EF-hand motifs. It promotes the dephosphorylation of the product of ninaE, which prevents its internalization. It also promotes the dephosphorylation of the product of trp at specific site affecting the frequency response to modulated light. (746 aa) |
| | Pp2C1 | Protein phosphatase 2C, isoform A; Cation binding; mitogen-activated protein kinase binding; magnesium-dependent protein serine/threonine phosphatase activity; oxidoreductase activity; protein serine/threonine phosphatase activity. It is involved in the biological process described with: oxidation-reduction process; protein dephosphorylation. (1427 aa) |
| | RpII140 | DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...] (1176 aa) |
| | Nsf2 | Vesicle-fusing ATPase 2; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity). (752 aa) |
| | Alp8 | Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (533 aa) |
| | CG15743 | Inositol-1,4-bisphosphate 1-phosphatase activity; 3'-nucleotidase activity; inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: signal transduction; dephosphorylation; phosphate-containing compound metabolic process; phosphatidylinositol phosphorylation; phosphatidylinositol biosynthetic process. (355 aa) |
| | awd | Nucleoside diphosphate kinase; Abnormal wing discs (awd) encodes a nucleotide diphosphate kinase that regulates with the product of shi the endocytosis of different surface proteins (e.g. those encoded by N, btl, Pvr, and shg). During development, it regulates morphogenesis of trachea, follicular epithelium, and imaginal discs and contributes to neurotransmission and border cell migration; Belongs to the NDK family. (168 aa) |
| | vas | ATP-dependent RNA helicase vasa; Involved in translational control mechanisms operating in early stages of oogenesis. Required maternally in many stages of oogenesis, including cystocyte differentiation, oocyte differentiation, and specification of anterior-posterior polarity in the developing cysts. Essential for the formation and/or structural integrity of perinuclear nuage particles during germ cell formation. Required for gus, Fsn and aub accumulation at the posterior pole of the embryo. Required for the localization of vas to the perinuclear region of nurse cells. Belongs to the D [...] (661 aa) |
| | CG1354 | Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (427 aa) |
| | nmo | Mitogen-activated protein kinase; Nemo (nmo) encodes an atypical proline-directed serine/threonine kinase with roles in numerous developmental processes, including ommatidial rotation/planar cell polarity, retinal specification and neuronal function, and circadian clock speed. It regulates the activity of several signal transduction pathways, including BMP, Wnt, and Notch, and is implicated in fly models of neurodegenerative diseases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (439 aa) |
| | mbt | Serine/threonine-protein kinase PAK mbt; Involved in neurogenesis of the adult central nervous system, and together with Cdc42, regulates photoreceptor cell morphogenesis. Phosphorylates exogenous substrates when activated by Cdc42. (639 aa) |
| | Rok | Rho-associated protein kinase; Rho kinase (Rok) encodes a kinase that, when activated by the GTP form of the product of Rho1, phosphorylates and modulates cytoskeletal proteins, particularly myosin II. Dynamic regulation of this kinase in subcellular locales influences cell polarization, movement, and shape during interphase and mitosis. (1390 aa) |
| | CG14212 | Uncharacterized protein; Phosphatase activity; pyrophosphatase activity. (262 aa) |
| | CG12237 | LP01149p; Pyrophosphatase activity; phosphatase activity. (306 aa) |
| | Galphaf | G protein alpha f subunit (Galphaf) encodes a transcriptional target of the JAK/STAT pathway in blood cells where it regulates cell shape and function; Belongs to the G-alpha family. (399 aa) |
| | Pgm1 | Phosphoglucomutase; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (560 aa) |
| | CG17026 | Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: inositol metabolic process; signal transduction; inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation. (284 aa) |
| | CG17028 | Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation; signal transduction; inositol metabolic process. (284 aa) |
| | AGO2 | Protein argonaute-2; Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger; Belongs to the argonaute family. Ago subfamily. (1217 aa) |
| | nst | Nesthocker (nst) encodes a phospho-acetylglucosamine mutase, an essential enzyme in the biosynthetic pathway of N-Acetylglucosamine (GlcNAc). In the embryo, it is required for normal GlcNAc levels and affects Fibroblast-Growth-Factor signaling. (549 aa) |
| | aay | Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity); Belongs to the HAD-like hydrolase superfamily. SerB family. (270 aa) |
| | Galphai | G protein alpha i subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphao and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa) |
| | Prat2 | Amidophosphoribosyltransferase; Phosphoribosylamidotransferase 2 (Prat2) encodes a type-2 glutamine amidotransferase that is essential in the pathway for de novo synthesis of inosine monophosphate (IMP). IMP is the precursor for purine nucleotides that are required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (547 aa) |
| | Myt1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of Cdk1 specifically when Cdk1 is complexed to cyclins. Mediates phosphorylation of Cdk1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of Cdk1 on 'Tyr- 15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Belongs to the protein kinase superfamily. Ser/Thr [...] (533 aa) |
| | ScsbetaG | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (416 aa) |
| | Gen | Flap endonuclease GEN; Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'- overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded. Also possesses weak 5'- to 3'- exonuclease activity on nicked but not gapped double-stranded DNA. Does not cleave bubble-like or Holliday junction substrates. (726 aa) |
| | Tak1 | Mitogen-activated protein kinase kinase kinase 7; Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Responsible for activation of the JNK MAPK pathway (basket, bsk and hemipterous, hep) in response to LPS. Component of the NF-kappa-B pathway; relish-mediated JNK inhibition involves proteasomal degradation of Tak1; certain targets of Relish that are induced during immune responses may facilitate destruction of Tak1 and switch off the JNK cascade. Participates in diverse roles such as control of cell shape and regulation of apoptosis. (678 aa) |
| | CG3008 | Serine/threonine-protein kinase RIO3; Protein serine/threonine kinase activity; protein kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; maturation of SSU-rRNA; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (603 aa) |
| | Naprt | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family. (667 aa) |
| | CG2964 | Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process. (554 aa) |
| | Eno | Enolase (Eno) encodes a phosphopyruvate hydratase involved in glucose homeostasis; Belongs to the enolase family. (500 aa) |
| | DNApol-eta | DNApol-eta; DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Inserts one or 2 nucleotide(s) opposite the lesion. During homologous recombination (HR) repair, has a overlapping role with the error-prone translesion polymerase DNApol-zeta/DNApolZ1 to initiate repair synthesis that is completed by end joining or another polymerase that can bind and reinitiate synthesis. Particularly important for the repair of UV-in [...] (885 aa) |
| | Rheb | GTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity (By similarity). Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K through activation of TORC1 signaling. May also have a role in activating TORC2 signaling. (182 aa) |
| | Nmdar1 | Glutamate [NMDA] receptor subunit 1; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation. (997 aa) |
| | CG12173 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (256 aa) |
| | CG8891 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (191 aa) |
| | Pfas | Phosphoribosylformylglycinamidine synthase (Pfas) encodes a phosphoribosylformylglycinamidine synthase, which is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the N-terminal section; belongs to the FGAMS family. (1354 aa) |
| | eya | Developmental protein eyes absent; Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. The phosphatase activity was shown in vitro. Appears to function together with So and Dac in eye development. Required for the survival of eye progenitor cells at a critical stage in morphogenesis. Belongs to the HAD-like hydrolase superfamily. EYA family. (766 aa) |
| | MME1 | Mitochondrial magnesium exporter 1; Mediates efflux of magnesium ions from mitochondria, suggesting a role in magnesium homeostasis. (299 aa) |
| | CG7115 | Uncharacterized protein, isoform A; Cation binding; magnesium-dependent protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation. (524 aa) |
| | C1GalTA | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Core 1 Galactosyltransferase A (C1GalTA) encodes a protein that exhibits strong core 1beta1,3GalT activity, and is involved in the synthesis of T antigen in hemocytes. Its roles include hematopoietic stem cell maintenance, neural network and neuromuscular junction formation. (388 aa) |
| | piwi | Protein piwi; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael-dependent manner. [...] (843 aa) |
| | aurB | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. (329 aa) |
| | CG6230 | Cation-transporting ATPase; Ion transmembrane transporter activity, phosphorylative mechanism; nucleotide binding; ATPase activity. It is involved in the biological process described with: cellular calcium ion homeostasis; cation transport; transmembrane transport; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1225 aa) |
| | CG17010 | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (429 aa) |
| | CG31729 | ATP binding; magnesium ion binding; ATPase-coupled intramembrane lipid transporter activity. It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; phospholipid translocation; endocytosis; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1256 aa) |
| | tam | DNA polymerase subunit gamma-1, mitochondrial; As the catalytic component of the DNA polymerase gamma complex is involved in the replication of mitochondrial DNA (mtDNA). Has both 5'-3' DNA polymerase and a highly mispair-specific 3'-5' exonuclease activity. At the end of mtDNA replication DNA ends are ligated to produce a closed circular mtDNA molecule, its exonuclease activity is required for formation of these ligatable ends by preventing DNA synthesis from continuing past the 5'-end of downstream DNA into duplex DNA regions. Does not possess DNA primase activity, does not catalyze [...] (1145 aa) |
| | THG | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (286 aa) |
| | tos | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). (732 aa) |
| | Nbr | Exonuclease mut-7 homolog; Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs, in particular multiple-isoform miRNAs, which represents a critical step in miRNA maturation. Belongs to the mut-7 family. (625 aa) |
| | CG2846 | Putative riboflavin kinase; Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN). (153 aa) |
| | Nmdmc | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; May play a role in spermatogenesis. (309 aa) |
| | phu | Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation; response to hypoxia; response to nicotine. (546 aa) |
| | CG33331 | Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. (342 aa) |
| | glob1 | Globin 1 (glob1) encodes a peroxidase involved in the response to oxidative stress and the maintenance of F-actin based cytoskeleton. (153 aa) |
| | Gyc89Db | Soluble guanylate cyclase 89Db; Heterodimers with Gyc88E are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (669 aa) |
| | AdSS | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. (447 aa) |
| | Takl1 | ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity. (393 aa) |
| | Alp5 | Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (522 aa) |
| | cin | Molybdenum cofactor synthesis protein cinnamon; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released; In the N-terminal section; belongs to the MoaB/Mog family. (601 aa) |
| | CG13369 | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (304 aa) |
| | MTPAP | Poly(A) RNA polymerase, mitochondrial; Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. This is not required for transcript stability or translation but may maintain mRNA integrity by protecting 3' termini from degradation. (612 aa) |
| | CG15035 | Phosphoprotein phosphatase activity; protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation; Belongs to the PP2C family. (374 aa) |
| | Alp2 | Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (538 aa) |
| | Alp7 | Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (543 aa) |
| | Galphas | G protein alpha s subunit (Galphas) encodes an alpha subunit of the class of heterotrimeric G proteins, found on the cytosolic face of the plasma membrane. An inactive GDP-bound form forms a heterotrimer with beta and gamma subunits. On activation by a 7-TM receptor, the product of Galphas exchanges GDP for GTP, dissociates from the trimer, and activates adenylyl cyclase, thus initiating cAMP signaling. Galphas roles include neurophysiology, and behaviors including learning; Belongs to the G-alpha family. G(s) subfamily. (385 aa) |
| | SERCA | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. (1020 aa) |
| | cN-IIIB | 7-methylguanosine phosphate-specific 5'-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. Also able to mediate hydrolysis of diphosphate (m(7)GDP) to 7-methylguanosine and 2 inorganic phosphate with lower activity. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates. Belongs to the pyrimidine 5'-nucleotidase family. (319 aa) |
| | Nurf-38 | Inorganic pyrophosphatase; Component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. NURF is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. Nurf-38 may have adapted to deliver pyrophosphatase to chromatin to assist in replication or transcription by efficient removal of the inhibitory metabolite; Belongs to the PPase family. (338 aa) |
| | Ppm1 | AT28366p; Cation binding; protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity. It is involved in the biological process described with: protein dephosphorylation. (352 aa) |
| | Rev1 | DNA repair protein Rev1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). During homologous recombination (HR) repair of DNA double-strand breaks (DSBs) regulates the extent of repair synthesis. Possibly recruits the DNA polymerase zeta complex or another translesion polymerase to earl [...] (995 aa) |
| | oxt | Xylosyltransferase oxt; Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes; Belongs to the glycosyltransferase 14 family. XylT subfamily. (876 aa) |
| | nSMase | Putative neutral sphingomyelinase; Sphingomyelin phosphodiesterase activity. It is involved in the biological process described with: sphingomyelin metabolic process. (442 aa) |
| | CG17746 | LD28127p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding. It is involved in the biological process described with: protein dephosphorylation. (371 aa) |
| | Faa | Fumarylacetoacetase activity. It is involved in the biological process described with: L-phenylalanine catabolic process; homogentisate catabolic process; tyrosine catabolic process. (417 aa) |
| | Ran | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (216 aa) |
| | RpII215 | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1887 aa) |
| | FucT6 | Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. The addition is prevented if the GlcNAc residue is already fucosylated. (619 aa) |
| | Fpgs | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (572 aa) |
| | CkIalpha | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Negative regulator of wg signaling. Phosphorylates arm directly or indirectly and stimulates its degradation which prevents inappropriate wg signaling. Phosphorylates smo which promotes its accumulation at the cell surface and its signaling activity in response to hh. Together with dco, regulates proteolytic processing of ci by phosphorylating it which promotes its binding to slmb, the F [...] (337 aa) |
| | comt | Vesicle-fusing ATPase 1; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin; Belongs to the AAA ATPase family. (745 aa) |
| | rut | Ca(2+)/calmodulin-responsive adenylate cyclase; Rutabaga (rut) encodes a membrane-bound Ca[2+]/calmodulin-activated adenylyl cyclase that is responsible for synthesis of cAMP. It plays a key role in regulating behavioral, neuroanatomical, and electrophysiological plasticity. (2248 aa) |
| | Pis | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content (By similarity). The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5- bisphosphate (PtdInsP2) from phosphatidic acid (PA) and maintenance of its steady supply during signaling, thus playing [...] (224 aa) |
| | CG4301 | ATPase-coupled intramembrane lipid transporter activity; ATP binding; magnesium ion binding. It is involved in the biological process described with: phospholipid translocation; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1342 aa) |
| | PyK | Pyruvate kinase (PyK) encodes an enzyme involved in muscle development, glycolysis and glucose homeostasis; Belongs to the pyruvate kinase family. (533 aa) |
| | CG7069 | Pyruvate kinase activity; potassium ion binding; magnesium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process. (744 aa) |
