12 items (Drosophila melanogaster) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KLHL18	Kelch like family member 18, isoform A; Protein homodimerization activity. It is involved in the biological process described with: protein autoubiquitination; imaginal disc fusion, thorax closure. (575 aa)
	Keap1	Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. (776 aa)
	Lztr1	Leucine-zipper-like transcriptional regulator 1 homolog; Inhibitor of Ras signaling. Acts as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin- protein ligase complex that mediates ubiquitination of Ras (By similarity); Belongs to the LZTR1 family. (998 aa)
	Hcf	HCF C-terminal chain; May be involved in control of the cell cycle. (1500 aa)
	kel	Ring canal kelch protein; Kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals. (1477 aa)
	CG9426	GH03286p; Actin binding. (627 aa)
	CG1812	LD33804p. (616 aa)
	slim	Kelch domain-containing protein 10 homolog; Activates the Pk92B/DASK1-MAPK signaling cascade. (609 aa)
	klhl10	Kelch like family member 10 (klhl10) encodes a protein that functions in spermatogenesis. It recruits substrates for a testis specific Cullin-3-based E3 ubiquitin ligase complex, which is required for caspase activation during the non-apoptotic process of spermatid terminal differentiation. (767 aa)
	CG15097	Uncharacterized protein, isoform E. (743 aa)
	CG17754	LP02641p. (654 aa)
	dbo	Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth. (623 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG17754	CG1812	FBpp0071251	FBpp0077004	LP02641p.	LD33804p.	0.421
CG17754	Keap1	FBpp0071251	FBpp0082864	LP02641p.	Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress.	0.439
CG17754	dbo	FBpp0071251	FBpp0075260	LP02641p.	Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth.	0.432
CG17754	kel	FBpp0071251	FBpp0080596	LP02641p.	Ring canal kelch protein; Kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals.	0.475
CG1812	CG17754	FBpp0077004	FBpp0071251	LD33804p.	LP02641p.	0.421
CG1812	Keap1	FBpp0077004	FBpp0082864	LD33804p.	Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress.	0.421
CG1812	dbo	FBpp0077004	FBpp0075260	LD33804p.	Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth.	0.429
CG1812	kel	FBpp0077004	FBpp0080596	LD33804p.	Ring canal kelch protein; Kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals.	0.421
KLHL18	klhl10	FBpp0307415	FBpp0112409	Kelch like family member 18, isoform A; Protein homodimerization activity. It is involved in the biological process described with: protein autoubiquitination; imaginal disc fusion, thorax closure.	Kelch like family member 10 (klhl10) encodes a protein that functions in spermatogenesis. It recruits substrates for a testis specific Cullin-3-based E3 ubiquitin ligase complex, which is required for caspase activation during the non-apoptotic process of spermatid terminal differentiation.	0.740
Keap1	CG17754	FBpp0082864	FBpp0071251	Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress.	LP02641p.	0.439
Keap1	CG1812	FBpp0082864	FBpp0077004	Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress.	LD33804p.	0.421
Keap1	dbo	FBpp0082864	FBpp0075260	Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress.	Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth.	0.420
Keap1	kel	FBpp0082864	FBpp0080596	Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress.	Ring canal kelch protein; Kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals.	0.477
dbo	CG17754	FBpp0075260	FBpp0071251	Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth.	LP02641p.	0.432
dbo	CG1812	FBpp0075260	FBpp0077004	Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth.	LD33804p.	0.429
dbo	Keap1	FBpp0075260	FBpp0082864	Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth.	Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress.	0.420
dbo	kel	FBpp0075260	FBpp0080596	Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth.	Ring canal kelch protein; Kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals.	0.462
kel	CG17754	FBpp0080596	FBpp0071251	Ring canal kelch protein; Kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals.	LP02641p.	0.475
kel	CG1812	FBpp0080596	FBpp0077004	Ring canal kelch protein; Kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals.	LD33804p.	0.421
kel	Keap1	FBpp0080596	FBpp0082864	Ring canal kelch protein; Kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals.	Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress.	0.477