(5 nodes) (2000) The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family. network (Drosophila melanogaster)

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Your Input:
	Brd	Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification. (81 aa)
	E(spl)m6-BFM	Enhancer of split m6 protein; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development; cell fate specification. (70 aa)
	E(spl)m2-BFM	Enhancer of split M2 protein; Part of the Notch signaling pathway. (218 aa)
	Sply	Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily. (545 aa)
	Ocho	Ocho, isoform B; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development. (149 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brd	E(spl)m2-BFM	FBpp0075374	FBpp0084354	Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification.	Enhancer of split M2 protein; Part of the Notch signaling pathway.	0.709
Brd	E(spl)m6-BFM	FBpp0075374	FBpp0084333	Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification.	Enhancer of split m6 protein; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development; cell fate specification.	0.659
Brd	Ocho	FBpp0075374	FBpp0289057	Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification.	Ocho, isoform B; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development.	0.830
Brd	Sply	FBpp0075374	FBpp0086158	Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification.	Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily.	0.837
E(spl)m2-BFM	Brd	FBpp0084354	FBpp0075374	Enhancer of split M2 protein; Part of the Notch signaling pathway.	Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification.	0.709
E(spl)m2-BFM	E(spl)m6-BFM	FBpp0084354	FBpp0084333	Enhancer of split M2 protein; Part of the Notch signaling pathway.	Enhancer of split m6 protein; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development; cell fate specification.	0.791
E(spl)m2-BFM	Ocho	FBpp0084354	FBpp0289057	Enhancer of split M2 protein; Part of the Notch signaling pathway.	Ocho, isoform B; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development.	0.683
E(spl)m2-BFM	Sply	FBpp0084354	FBpp0086158	Enhancer of split M2 protein; Part of the Notch signaling pathway.	Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily.	0.602
E(spl)m6-BFM	Brd	FBpp0084333	FBpp0075374	Enhancer of split m6 protein; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development; cell fate specification.	Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification.	0.659
E(spl)m6-BFM	E(spl)m2-BFM	FBpp0084333	FBpp0084354	Enhancer of split m6 protein; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development; cell fate specification.	Enhancer of split M2 protein; Part of the Notch signaling pathway.	0.791
E(spl)m6-BFM	Ocho	FBpp0084333	FBpp0289057	Enhancer of split m6 protein; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development; cell fate specification.	Ocho, isoform B; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development.	0.839
E(spl)m6-BFM	Sply	FBpp0084333	FBpp0086158	Enhancer of split m6 protein; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development; cell fate specification.	Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily.	0.669
Ocho	Brd	FBpp0289057	FBpp0075374	Ocho, isoform B; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development.	Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification.	0.830
Ocho	E(spl)m2-BFM	FBpp0289057	FBpp0084354	Ocho, isoform B; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development.	Enhancer of split M2 protein; Part of the Notch signaling pathway.	0.683
Ocho	E(spl)m6-BFM	FBpp0289057	FBpp0084333	Ocho, isoform B; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development.	Enhancer of split m6 protein; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development; cell fate specification.	0.839
Ocho	Sply	FBpp0289057	FBpp0086158	Ocho, isoform B; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development.	Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily.	0.529
Sply	Brd	FBpp0086158	FBpp0075374	Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily.	Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification.	0.837
Sply	E(spl)m2-BFM	FBpp0086158	FBpp0084354	Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily.	Enhancer of split M2 protein; Part of the Notch signaling pathway.	0.602
Sply	E(spl)m6-BFM	FBpp0086158	FBpp0084333	Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily.	Enhancer of split m6 protein; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development; cell fate specification.	0.669
Sply	Ocho	FBpp0086158	FBpp0289057	Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily.	Ocho, isoform B; Ubiquitin protein ligase binding. It is involved in the biological process described with: negative regulation of Notch signaling pathway; sensory organ development.	0.529