STRINGSTRING
gro gro tx tx SREBP SREBP sc sc ac ac hh hh CycA CycA ato ato
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
groGroucho (gro) encodes a global developmental co-repressor in conjunction with manifold DNA-binding repressor partner proteins, which tether it to target promoters. It functions downstream of key signaling pathways such as Wg/Wnt and Dpp/TGF-beta. Notably, phosphorylation of the product of gro in response to MAPK activation weakens its repressor capacity. (730 aa)
txHelix-loop-helix protein delilah; Taxi (tx) encodes a transcription factor that affects cell adhesion by regulating the expression of mys. It is involved in the development of multiple organs and cell-types including tendon cells, chordotonal organs and the wing. (384 aa)
SREBPSterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. (1113 aa)
scAchaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation. (345 aa)
acAchaete-scute complex protein T5; Achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development. (201 aa)
hhProtein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune r [...] (471 aa)
CycAG2/mitotic-specific cyclin-A; Cyclin A (CycA) encodes a protein that binds to the product of Cdk1, thereby promoting Cdk1's protein kinase activity. The CycA-Cdk1 complex controls important aspects of progression through the cell cycle, including entry into mitosis. During the G2 phase, this complex is important for prevention of premature DNA re-replication. During mitosis and G1, the product of CycA is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity. (491 aa)
atoProtein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection. (312 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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