STRINGSTRING
Hex-A Hex-A InR InR Hex-t1 Hex-t1 Hex-t2 Hex-t2 Hex-C Hex-C EcR EcR Lsp2 Lsp2 Act5C Act5C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Hex-APhosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis. (541 aa)
InRInsulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa)
Hex-t1Hexokinase type 1; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (465 aa)
Hex-t2Hexokinase type 2; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (486 aa)
Hex-CPhosphotransferase; Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis. (454 aa)
EcREcdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. (878 aa)
Lsp2Larval serum protein 2; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. (701 aa)
Act5CActin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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