30 items (Drosophila melanogaster) - STRING interaction network

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proteins of unknown 3D structure

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Predicted Interactions

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	Lsp1beta	Larval serum protein 1 beta chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. (789 aa)
	CG42258	Uncharacterized protein, isoform C. (465 aa)
	hwt	Heavyweight, isoform A; Phosphotyrosine residue binding. It is involved in the biological process described with: regulation of establishment of planar polarity. (1768 aa)
	inaF-D	inaF-D (inaF-D) contains four small ORFs named inaF-A, B, C, and D, each of which is spliced to the same down-stream exon. Mutations in inaF-D greatly suppress the expression of the photoreceptor channel protein encoded by trp. (353 aa)
	Sxl	Protein sex-lethal; Sex determination switch protein which controls sexual development by sex-specific splicing. Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes. Expression of the embryo-specific isoform is under the control of primary sex- determining signal, which depends on the ratio of X chromosomes relative to autosomes (X:A ratio). Expression occurs in 2X:2A cells, but not in X:2A cells. The X:A ratio seems to be signaled by the relative concentration of the X-linked transcription factors SIS-A and SIS-B. As a result, the embryo-specific [...] (722 aa)
	CG15309	Protein yippee-like CG15309; Belongs to the yippee family. (114 aa)
	Pgd	6-phosphogluconate dehydrogenase, decarboxylating; Phosphogluconate dehydrogenase (Pgd) encodes a cytosolic enzyme that catalyzes the oxidation of 6-phosphogluconate to ribulose 5-phosphate, with the concomitant reduction of NADP[+] to NADPH. The products of Pgd and Zw are the two NADP[+] reducing enzymes in the pentose phosphate pathway. (481 aa)
	mof	Males-absent on the first protein; Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the MSL complex. Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex. As part of the NSL complex may associate with promoters of X chromosomal as well as autosomal genes and positivel [...] (827 aa)
	Lsp1gamma	Larval serum protein 1 gamma chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. (772 aa)
	Cpr11A	Cuticular protein 11A; Structural constituent of chitin-based larval cuticle; structural constituent of cuticle. It is involved in the biological process described with: chitin-based cuticle development. (270 aa)
	Lsp1alpha	Larval serum protein 1 alpha chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. (816 aa)
	CG2556	RE14150p. (470 aa)
	Mks1	Meckel syndrome type 1 protein homolog; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function. (699 aa)
	Rab40	Rab40, isoform B; GTP binding; GTPase activity. It is involved in the biological process described with: protein localization to plasma membrane; vesicle-mediated transport; Rab protein signal transduction; intracellular protein transport. (265 aa)
	Lsd-2	Lipid storage droplet-2 (Lsd-2) encodes a protein associated with lipid droplets. It acts as a barrier for lipases (such as the product of bmm) and thus prevents the mobilization of lipid stores. It is involved in regulation of lipid storage amount and energy homeostasis and acts in concert with the product of Lsd-1; Belongs to the perilipin family. (352 aa)
	msl-3	Protein male-specific lethal-3; Male-specific lethal 3 (msl-3) encodes a chromodomain protein, reported to interact with H3K36me3, H4K20me1 and DNA. It is a member of the Male-Specific-Lethal dosage compensation complex, which increases male X chromosome transcription approximately two-fold. Homozygous mutant males die as larvae, while females are viable. (512 aa)
	CG1631	IP11023p. (183 aa)
	l(1)G0004	RNA-binding protein pno1; RNA binding. (240 aa)
	Rab10	LD39986p; Rab10 (Rab10) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in basement membrane organization. (204 aa)
	msl-2	E3 ubiquitin-protein ligase msl-2; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B. Belongs to the MSL2 family. (773 aa)
	Gal	Beta galactosidase (Gal) encodes a putative digestive enzyme that hydrolyses beta-galactosides into monosaccharides. Gal is highly expressed and enriched in the midgut, an organ involved in digestion; Belongs to the glycosyl hydrolase 35 family. (672 aa)
	Dref	DNA replication-related element factor (Dref) encodes a BED finger-type transcription factor that binds to the DRE sequence (TATCGATA). The Dref product is involved in tumor suppressor, TOR, JNK and EGFR signalling pathways. It also plays a role in chromatin organization including insulator function, chromatin remodeling, and telomere maintenance. (709 aa)
	msl-1	Protein male-specific lethal-1; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-1 is a pioneer protein. Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding. In complex with msl-2, promotes ubiquitination of histone H2B. (1039 aa)
	His4r	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	RpL32	60S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
	mle	Dosage compensation regulator; Required in males for dosage compensation of X chromosome linked genes. Mle, msl-1 and msl-3 are colocalized on X chromosome. Each of the msl proteins requires all the other msls for wild-type X- chromosome binding. Probably unwinds double-stranded DNA and RNA in a 3' to 5' direction; Belongs to the DEAD box helicase family. DEAH subfamily. (1293 aa)
	Gpdh1	Glycerol-3-phosphate dehydrogenase 1 (Gpdh1) encodes a glycerol-3-phosphate dehydrogenase that catalyzes the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate. It is involved in triglyceride metabolism, response to hyperoxia and flight behavior. (360 aa)
	Ntf-2	Nuclear transport factor-2 (Ntf-2) is an essential gene regulating nuclear import. It encodes a protein that binds to the nuclear pore protein encoded by DCTN4-p62 and to the product of Ran and regulates the nuclear import of nuclear localization signal containing proteins. (130 aa)
	CG1529	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II. (512 aa)
	ATPsyndelta	ATP synthase, delta subunit, isoform A; Proton-transporting ATP synthase activity, rotational mechanism. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport. (157 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATPsyndelta	CG1529	FBpp0310433	FBpp0309383	ATP synthase, delta subunit, isoform A; Proton-transporting ATP synthase activity, rotational mechanism. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport.	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	0.600
ATPsyndelta	CG15309	FBpp0310433	FBpp0305121	ATP synthase, delta subunit, isoform A; Proton-transporting ATP synthase activity, rotational mechanism. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport.	Protein yippee-like CG15309; Belongs to the yippee family.	0.491
ATPsyndelta	RpL32	FBpp0310433	FBpp0084959	ATP synthase, delta subunit, isoform A; Proton-transporting ATP synthase activity, rotational mechanism. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport.	60S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation.	0.466
CG1529	ATPsyndelta	FBpp0309383	FBpp0310433	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	ATP synthase, delta subunit, isoform A; Proton-transporting ATP synthase activity, rotational mechanism. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport.	0.600
CG1529	CG15309	FBpp0309383	FBpp0305121	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	Protein yippee-like CG15309; Belongs to the yippee family.	0.693
CG1529	CG1631	FBpp0309383	FBpp0076989	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	IP11023p.	0.525
CG1529	CG2556	FBpp0309383	FBpp0073485	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	RE14150p.	0.481
CG1529	CG42258	FBpp0309383	FBpp0288833	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	Uncharacterized protein, isoform C.	0.602
CG1529	Cpr11A	FBpp0309383	FBpp0073483	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	Cuticular protein 11A; Structural constituent of chitin-based larval cuticle; structural constituent of cuticle. It is involved in the biological process described with: chitin-based cuticle development.	0.474
CG1529	Lsp1alpha	FBpp0309383	FBpp0073484	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	Larval serum protein 1 alpha chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family.	0.536
CG1529	Ntf-2	FBpp0309383	FBpp0305904	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	Nuclear transport factor-2 (Ntf-2) is an essential gene regulating nuclear import. It encodes a protein that binds to the nuclear pore protein encoded by DCTN4-p62 and to the product of Ran and regulates the nuclear import of nuclear localization signal containing proteins.	0.434
CG1529	inaF-D	FBpp0309383	FBpp0290482	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	inaF-D (inaF-D) contains four small ORFs named inaF-A, B, C, and D, each of which is spliced to the same down-stream exon. Mutations in inaF-D greatly suppress the expression of the photoreceptor channel protein encoded by trp.	0.400
CG1529	l(1)G0004	FBpp0309383	FBpp0076990	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	RNA-binding protein pno1; RNA binding.	0.451
CG1529	msl-1	FBpp0309383	FBpp0080674	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	Protein male-specific lethal-1; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-1 is a pioneer protein. Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding. In complex with msl-2, promotes ubiquitination of histone H2B.	0.535
CG1529	msl-3	FBpp0309383	FBpp0076635	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	Protein male-specific lethal-3; Male-specific lethal 3 (msl-3) encodes a chromodomain protein, reported to interact with H3K36me3, H4K20me1 and DNA. It is a member of the Male-Specific-Lethal dosage compensation complex, which increases male X chromosome transcription approximately two-fold. Homozygous mutant males die as larvae, while females are viable.	0.458
CG15309	ATPsyndelta	FBpp0305121	FBpp0310433	Protein yippee-like CG15309; Belongs to the yippee family.	ATP synthase, delta subunit, isoform A; Proton-transporting ATP synthase activity, rotational mechanism. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport.	0.491
CG15309	CG1529	FBpp0305121	FBpp0309383	Protein yippee-like CG15309; Belongs to the yippee family.	Uncharacterized protein, isoform C; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.	0.693
CG15309	CG1631	FBpp0305121	FBpp0076989	Protein yippee-like CG15309; Belongs to the yippee family.	IP11023p.	0.439
CG15309	CG42258	FBpp0305121	FBpp0288833	Protein yippee-like CG15309; Belongs to the yippee family.	Uncharacterized protein, isoform C.	0.491
CG15309	Lsp1alpha	FBpp0305121	FBpp0073484	Protein yippee-like CG15309; Belongs to the yippee family.	Larval serum protein 1 alpha chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family.	0.438