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png | Pan gu (png) encodes a Ser/Thr kinase that controls the translation of hundreds of mRNAs, such as CycB and smg, during the oocyte-to-embryo transition. The activation of the product of png requires the formation of a complex with the two activating subunits encoded by plu and gnu. (291 aa) | ||||
gnu | CG5272 protein; Giant nuclei (gnu) encodes a regulatory subunit of the PNG kinase complex, which regulates the levels of the protein encoded by CycB. Members of this complex are required maternally for the normal nuclear divisions of the syncytial embryo. (240 aa) | ||||
plu | DNA replication inhibitor plutonium; Plutonium (plu) encodes a protein that binds to and activates the kinase encoded by png. plu mutants are female sterile, and they result in embryos with giant nuclei due to failure to translate CycB mRNA resulting in DNA replication in the absence of mitosis. (174 aa) |