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Ilp6 Ilp6 CG10802 CG10802 CG4586 CG4586 tud tud CG9485 CG9485 CG14995 CG14995 Lsp1alpha Lsp1alpha CG7430 CG7430 tra tra cbt cbt CG31775 CG31775 abd-A abd-A Cpr97Eb Cpr97Eb CG1441 CG1441 Tm1 Tm1 tra2 tra2 GstT3 GstT3 fru fru LpR1 LpR1 CG15347 CG15347 Nipped-A Nipped-A dsx dsx Slc45-1 Slc45-1 CG8086 CG8086 slf slf fln fln ImpE1 ImpE1 Yp2 Yp2 ssx ssx CG15369 CG15369 Yp1 Yp1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Ilp6Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation. (107 aa)
CG10802LD13611p; Ser-tRNA(Ala) hydrolase activity; ATP binding; nucleic acid binding; alanine-tRNA ligase activity. It is involved in the biological process described with: alanyl-tRNA aminoacylation; regulation of translational fidelity. (436 aa)
CG4586Acyl-coenzyme A oxidase; Flavin adenine dinucleotide binding; FAD binding; fatty acid binding; acyl-CoA oxidase activity. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (677 aa)
tudMaternal protein tudor; Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. (2515 aa)
CG9485Uncharacterized protein, isoform B; 4-alpha-glucanotransferase activity; amylo-alpha-1,6-glucosidase activity. It is involved in the biological process described with: glycogen biosynthetic process; glycogen catabolic process. (1629 aa)
CG14995Uncharacterized protein, isoform A; It is involved in the biological process described with: cytoskeleton organization; cilium organization; cilium assembly. (454 aa)
Lsp1alphaLarval serum protein 1 alpha chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. (816 aa)
CG7430Flavin adenine dinucleotide binding; dihydrolipoyl dehydrogenase activity; electron transfer activity. It is involved in the biological process described with: tricarboxylic acid cycle; lipoamide metabolic process; oxidation-reduction process; glycine catabolic process; cell redox homeostasis. (504 aa)
traFemale-specific protein transformer; Member of the regulatory pathway controlling female somatic sexual differentiation, regulated by Sxl. Activates dsx female-specific splicing by promoting the formation of a splicing enhancer complex which consists of tra, tra2 and sr proteins. Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. No known function in males. (197 aa)
cbtCabut, isoform A; Cabut (cbt) encodes a transcription factor that controls Dpp signaling and is involved in dorsal closure and wing disc morphogenesis. (428 aa)
CG31775RE38252p. (89 aa)
abd-AHomeobox protein abdominal-A; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for segmental identity of the second through eighth abdominal segments. Once a pattern of abd-A expression is turned on in a given parasegment, it remains on the more posterior parasegment, so that the complex pattern of expression is built up in the successive parasegments. Appears to repress expression of Ubx whenever they appear in the same cell, but abd-A is repressed [...] (590 aa)
Cpr97EbCuticular protein 97Eb; Structural constituent of cuticle; structural constituent of chitin-based larval cuticle. It is involved in the biological process described with: chitin-based cuticle development. (235 aa)
CG1441Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (517 aa)
Tm1Tropomyosin-1, isoforms 9A/A/B; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction; Belongs to the tropomyosin family. (711 aa)
tra2Transformer-2 sex-determining protein; Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female- specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to [...] (264 aa)
GstT3Glutathione S transferase T3 (GstT3) encodes an enzyme involved in glutathione metabolic processes; Belongs to the GST superfamily. (268 aa)
fruSex determination protein fruitless; Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associ [...] (960 aa)
LpR1Lipophorin receptor 1, isoform K; Lipophorin receptor 1 (LpR1) encodes a transmembrane receptor that regulates immune response by mediating clearance of the protein encoded by nec from the hemolymph. Some of the LpR1-encoded isoforms are also involved in the cellular uptake of neutral lipids from the circulating protein encoded by apolpp. (1076 aa)
CG15347LP18071p. (229 aa)
Nipped-ATranscription-associated protein 1; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double- strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. During wing development, required for activity of Notch and its coactivator mam. Function in promoting mam function is likely to involve both the Tip60 and SAGA complexes. (3790 aa)
dsxProtein doublesex; Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female- specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body. (572 aa)
Slc45-1Solute carrier family 45 member 1 (Slc45-1) encodes a proton/sucrose symporter occuring in apical membranes of the late embryonic hindgut as well as in vesicular membranes of ovarian follicle cells. It may either serve as an osmolyte transporter or be responsible for the resorption of sucrose. (599 aa)
CG8086Uncharacterized protein, isoform I; It is involved in the biological process described with: sensory perception of sound. (1603 aa)
slfC-type lectin 27kD, isoform A; Schlaff (slf) encodes a chitin binding protein involved in wing formation and the substrate for the product of Tg. (231 aa)
flnFlightin (fln) encodes an indirect flight muscle specific protein, not expressed in other muscle types. It is required for the correct assembly of the myosin thick filament during flight muscle development in pupae. fln null mutants cannot fly and show a progressive flight muscle loss as adults. This loss is most likely caused by uncontrolled hypercontraction. (182 aa)
ImpE1Ecdysone-inducible gene E1 (ImpE1) encodes a protein similar to a low-density lipoprotein (LDL) receptor. It is hypothesized to play a role in the cell rearrangements associated with morphogenesis of the disc epithelium. ImpE1 transcription is upregulated by 20-hydroxyecdysone. (1616 aa)
Yp2Vitellogenin-2; Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis; Belongs to the AB hydrolase superfamily. Lipase family. (442 aa)
ssxSister-of-Sex-lethal, isoform D; RNA binding; mRNA binding. It is involved in the biological process described with: defense response to bacterium; posttranscriptional gene silencing; regulation of RNA splicing. (485 aa)
CG15369GEO12084p1; Cysteine-type endopeptidase inhibitor activity. (122 aa)
Yp1Vitellogenin-1; Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis; Belongs to the AB hydrolase superfamily. Lipase family. (439 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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