AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP- 2alpha is a subunit of the plasma membrane adapter.

Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation.

AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP- 2alpha is a subunit of the plasma membrane adapter.

Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity.

AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP- 2alpha is a subunit of the plasma membrane adapter.

E3 ubiquitin-protein ligase Su(dx); E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation.

AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP- 2alpha is a subunit of the plasma membrane adapter.

Numb (numb) encodes a membrane-associated inhibitor of Notch signaling. It controls neuroblast and sense organ precursor asymmetric division. It is asymmetrically localized during mitosis and segregates exclusively to one of two daughter cells.

AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP- 2alpha is a subunit of the plasma membrane adapter.

Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification.

Neurogenic protein big brain; Essential for proper differentiation of ectoderm. Acts synergistically with neurogenic locus proteins Notch and Delta during the separation of neural and epidermal cell lineages in response to the lateral inhibition signal. Voltage-insensitive monovalent cation channel. Ion transport is blocked by the presence of divalent cations. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Bearded (Brd) encodes a member of the Bearded family, which are small proteins containing predicted basic amphipathic alpha-helical domains in their N-terminal regions. The product of Brd is involved in Notch signaling pathway regulation and cell fate specification.

E3 ubiquitin-protein ligase mind-bomb; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl- dependent signalin [...]

Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation.

AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP- 2alpha is a subunit of the plasma membrane adapter.

Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation.

E3 ubiquitin-protein ligase Nedd-4; Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down- regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation.

Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation.

Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity.

Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation.

E3 ubiquitin-protein ligase Su(dx); E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation.

Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation.

E3 ubiquitin-protein ligase mind-bomb; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl- dependent signalin [...]

Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation.

Numb (numb) encodes a membrane-associated inhibitor of Notch signaling. It controls neuroblast and sense organ precursor asymmetric division. It is asymmetrically localized during mitosis and segregates exclusively to one of two daughter cells.

Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation.

Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C- terminal domain) of th [...]

Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...]

Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C- terminal domain) of th [...]

Mothers against decapentaplegic homolog; Smad on X (Smox) encodes the primary transcription factor that mediates Activin signalling. Upon phosphorylation by the receptor encoded by babo, it forms a complex with the co-Smad protein encoded by Med. This complex translocates to the nucleus where it regulates expression of target genes.

Contactin; Required for organization of septate junctions and paracellular barrier functions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion.

Protein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...]

Furin-like protease 1, isoforms 1/1-X/2; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

Meltrin (Meltrin) encodes an ADAM protein that belongs to the metzincin superfamily of metalloproteases. It is regulated by the homeobox protein encoded by vnd during embryonic development.

Furin-like protease 1, isoforms 1/1-X/2; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

E3 ubiquitin-protein ligase Nedd-4; Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down- regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation.

Furin-like protease 1, isoforms 1/1-X/2; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in Notch signaling. Initial fucosylation of Notch/N by POFUT1 generates a substrate for Fringe/Fng, an acetylglucosaminyltransferase that c [...]