node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACC | AGBE | FBpp0087947 | FBpp0086845 | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. | 0.532 |
ACC | Tps1 | FBpp0087947 | FBpp0077121 | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. | Trehalose-6-phosphate synthase 1 (Tps1) encodes the trehalose synthesis enzyme with an N-terminal trehalose-6-phosphate (T6P) synthase domain that catalyzes the production of T6P using glucose-6-phosphate and UDP-glucose. Its C-terminal T6P phosphatase domain dephosphorylates T6P to generate trehalose. | 0.487 |
ACC | UGP | FBpp0087947 | FBpp0099884 | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. | UTP--glucose-1-phosphate uridylyltransferase; UGP (UGP) encodes an enzyme involved in hyperoxia response. | 0.459 |
AGBE | ACC | FBpp0086845 | FBpp0087947 | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. | 0.532 |
AGBE | Cyt-c-p | FBpp0086845 | FBpp0080446 | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. | Cytochrome c-2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.661 |
AGBE | GlyP | FBpp0086845 | FBpp0077501 | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. | Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). Required for glycogen breakdown in skeletal muscle. | 0.999 |
AGBE | Lsp1beta | FBpp0086845 | FBpp0311765 | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. | Larval serum protein 1 beta chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. | 0.459 |
AGBE | Lsp1gamma | FBpp0086845 | FBpp0072365 | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. | Larval serum protein 1 gamma chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. | 0.418 |
AGBE | Tps1 | FBpp0086845 | FBpp0077121 | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. | Trehalose-6-phosphate synthase 1 (Tps1) encodes the trehalose synthesis enzyme with an N-terminal trehalose-6-phosphate (T6P) synthase domain that catalyzes the production of T6P using glucose-6-phosphate and UDP-glucose. Its C-terminal T6P phosphatase domain dephosphorylates T6P to generate trehalose. | 0.721 |
AGBE | UGP | FBpp0086845 | FBpp0099884 | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. | UTP--glucose-1-phosphate uridylyltransferase; UGP (UGP) encodes an enzyme involved in hyperoxia response. | 0.922 |
AGBE | regucalcin | FBpp0086845 | FBpp0073422 | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. | Regucalcin, isoform D; Calcium ion binding; gluconolactonase activity. It is involved in the biological process described with: L-ascorbic acid biosynthetic process; multicellular organism reproduction. | 0.461 |
Cyt-c-d | Cyt-c-p | FBpp0080445 | FBpp0080446 | Cytochrome c-1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | Cytochrome c-2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.920 |
Cyt-c-d | Pink1 | FBpp0080445 | FBpp0099833 | Cytochrome c-1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. | 0.862 |
Cyt-c-d | UQCR-C1 | FBpp0080445 | FBpp0082459 | Cytochrome c-1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | Metalloendopeptidase activity; ubiquinol-cytochrome-c reductase activity; metal ion binding; endopeptidase activity. It is involved in the biological process described with: protein processing; protein processing involved in protein targeting to mitochondrion; mitochondrial electron transport, ubiquinol to cytochrome c. | 0.894 |
Cyt-c-d | betaTub56D | FBpp0080445 | FBpp0085721 | Cytochrome c-1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | 0.484 |
Cyt-c-d | park | FBpp0080445 | FBpp0077974 | Cytochrome c-1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | Parkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. | 0.807 |
Cyt-c-p | AGBE | FBpp0080446 | FBpp0086845 | Cytochrome c-2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. | 0.661 |
Cyt-c-p | Cyt-c-d | FBpp0080446 | FBpp0080445 | Cytochrome c-2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | Cytochrome c-1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.920 |
Cyt-c-p | Pink1 | FBpp0080446 | FBpp0099833 | Cytochrome c-2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. | 0.862 |
Cyt-c-p | UQCR-C1 | FBpp0080446 | FBpp0082459 | Cytochrome c-2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | Metalloendopeptidase activity; ubiquinol-cytochrome-c reductase activity; metal ion binding; endopeptidase activity. It is involved in the biological process described with: protein processing; protein processing involved in protein targeting to mitochondrion; mitochondrial electron transport, ubiquinol to cytochrome c. | 0.923 |