node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atg1 | Myc | FBpp0289788 | FBpp0303995 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. | Myc protein; Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiqui [...] | 0.502 |
B52 | CG8565 | FBpp0300515 | FBpp0073917 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. | 0.919 |
B52 | Rbp1 | FBpp0300515 | FBpp0081754 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | RNA-binding protein 1; Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site. Belongs to the splicing factor SR family. | 0.828 |
B52 | SC35 | FBpp0300515 | FBpp0297362 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | SR family splicing factor SC35 (SC35) encodes a mRNA binding protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. | 0.804 |
B52 | SF2 | FBpp0300515 | FBpp0293269 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | Splicing factor 2 (SF2) encodes a protein involved in alternative mRNA splicing, RNA export from the nucleus and the regulation of the RNA metabolism. | 0.671 |
B52 | SLIRP1 | FBpp0300515 | FBpp0076923 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | SRA stem-loop interacting RNA binding protein 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA processing; regulation of RNA metabolic process. | 0.630 |
B52 | SRPK | FBpp0300515 | FBpp0303478 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | SR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. | 0.893 |
B52 | Srpk79D | FBpp0300515 | FBpp0297551 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | Serine-arginine protein kinase at 79D (Srpk79D) is required to prevent the formation of axonal protein aggregates containing the active zone-protein encoded by brp. | 0.916 |
B52 | x16 | FBpp0300515 | FBpp0078996 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | X16 splicing factor (x16) encodes a protein involved in RNA splicing and RNA metabolism regulation. | 0.633 |
CG8565 | B52 | FBpp0073917 | FBpp0300515 | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | 0.919 |
CG8565 | Rbp1 | FBpp0073917 | FBpp0081754 | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. | RNA-binding protein 1; Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site. Belongs to the splicing factor SR family. | 0.568 |
CG8565 | Rim | FBpp0073917 | FBpp0293558 | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. | Rab3 interacting molecule (Rim) encodes a scaffolding protein at the synaptic active zone, with important roles in promoting neurotransmitter release. | 0.452 |
CG8565 | SC35 | FBpp0073917 | FBpp0297362 | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. | SR family splicing factor SC35 (SC35) encodes a mRNA binding protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. | 0.583 |
CG8565 | SF2 | FBpp0073917 | FBpp0293269 | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. | Splicing factor 2 (SF2) encodes a protein involved in alternative mRNA splicing, RNA export from the nucleus and the regulation of the RNA metabolism. | 0.632 |
CG8565 | sff | FBpp0073917 | FBpp0088511 | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. | Sugar-free frosting (sff) encodes a protein involved in neuromuscular junction development and protein N-linked glycosylation. | 0.814 |
CG8565 | x16 | FBpp0073917 | FBpp0078996 | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. | X16 splicing factor (x16) encodes a protein involved in RNA splicing and RNA metabolism regulation. | 0.572 |
Csp | Rim | FBpp0311238 | FBpp0293558 | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. | Rab3 interacting molecule (Rim) encodes a scaffolding protein at the synaptic active zone, with important roles in promoting neurotransmitter release. | 0.547 |
Csp | Syb | FBpp0311238 | FBpp0271782 | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. | Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release. | 0.771 |
Csp | Syn | FBpp0311238 | FBpp0099901 | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. | Synapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. | 0.662 |
Csp | brp | FBpp0311238 | FBpp0293597 | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. | Bruchpilot, isoform J; Bruchpilot (brp) encodes a cytoskeletal protein critical for structural integrity of electron-dense projection (T-bar) at pre-active zones. It contributes to Ca[2+] channel clustering, size regulation of the synaptic vesicle readily releaseable pool and anesthesia-resistant memory formation. | 0.869 |