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Rpt3 Rpt3 Mal-B2 Mal-B2 upd2 upd2 Mdr50 Mdr50 AkhR AkhR Npc2e Npc2e bmm bmm GlcAT-S GlcAT-S EcR EcR foxo foxo LManI LManI CG13325 CG13325 LManIII LManIII CG31091 CG31091 Lsp2 Lsp2 LManV LManV Jon65Ai Jon65Ai Lsp1gamma Lsp1gamma Lsd-2 Lsd-2 SREBP SREBP Fbp1 Fbp1 Jon65Aii Jon65Aii Npc2a Npc2a mag mag LManVI LManVI Mal-B1 Mal-B1 Npc2c Npc2c Npc2d Npc2d Fancl Fancl Npc2b Npc2b Hr96 Hr96 CG15533 CG15533 CG15534 CG15534 Npc2h Npc2h Npc2g Npc2g
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Rpt3Regulatory particle triple-A ATPase 3, isoform A; Proteasome-activating ATPase activity; ATPase activity; ATP binding. It is involved in the biological process described with: positive regulation of RNA polymerase II transcription preinitiation complex assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; protein catabolic process; Belongs to the AAA ATPase family. (413 aa)
Mal-B2Maltase B2, isoform E; Maltose alpha-glucosidase activity. It is involved in the biological process described with: carbohydrate metabolic process. (583 aa)
upd2Unpaired 2 (upd2) encodes a secreted molecule that acts at a distance as a ligand for the JAK/STAT signal transduction pathway. upd2 mutants are viable due to redundancy with other Upd-family genes. (406 aa)
Mdr50Multi drug resistance 50; Efflux transmembrane transporter activity; ATPase-coupled xenobiotic transmembrane transporter activity; ATPase activity; ATPase-coupled transmembrane transporter activity; ATP binding. It is involved in the biological process described with: response to insecticide; response to toxic substance; xenobiotic transport; transmembrane transport; renal tubular secretion. (1313 aa)
AkhRAdipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. (455 aa)
Npc2eNiemann-Pick type C-2e (Npc2e) encodes a protein involved in the immune signaling pathway via interaction with lipopolysaccharide, lipid A, peptidoglycan and lipoteichoic acid. (168 aa)
bmmBrummer, isoform B; Brummer (bmm) encodes a triglyceride lipase involved in glycerolipid metabolism, regulation of lipid storage and triglyceride homeostasis. (553 aa)
GlcAT-SGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase S; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity. (486 aa)
EcREcdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. (878 aa)
foxoForkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (622 aa)
LManILysosomal alpha-mannosidase I (LManI) encodes an enzyme that is involved in mannose metabolism using p-nitrophenyl-alpha-mannoside as a substrate. (950 aa)
CG13325GH20325p; Transferase activity, transferring acyl groups other than amino-acyl groups. (697 aa)
LManIIIAlpha-mannosidase activity; carbohydrate binding. It is involved in the biological process described with: mannose metabolic process; protein deglycosylation. (1003 aa)
CG31091Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (424 aa)
Lsp2Larval serum protein 2; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. (701 aa)
LManVAlpha-mannosidase activity; carbohydrate binding. It is involved in the biological process described with: mannose metabolic process; protein deglycosylation. (982 aa)
Jon65AiJonah 65Ai, isoform A; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. (262 aa)
Lsp1gammaLarval serum protein 1 gamma chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. (772 aa)
Lsd-2Lipid storage droplet-2 (Lsd-2) encodes a protein associated with lipid droplets. It acts as a barrier for lipases (such as the product of bmm) and thus prevents the mobilization of lipid stores. It is involved in regulation of lipid storage amount and energy homeostasis and acts in concert with the product of Lsd-1; Belongs to the perilipin family. (352 aa)
SREBPSterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. (1113 aa)
Fbp1Fat-body protein 1. (1029 aa)
Jon65AiiJonah 65Aii; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. (259 aa)
Npc2aNPC intracellular cholesterol transporter 2 homolog a; Functions redundantly with Npc2b in regulating sterol homeostasis and ecdysteroid biosynthesis, probably by controlling the availability of sterol substrate. (148 aa)
magLipase; Magro (mag) encodes a lipase induced by the product of Hr96 in the intestine, where it acts in the lumen to degrade dietary triglycerides for fatty acid absorption. (399 aa)
LManVIAlpha-mannosidase activity; carbohydrate binding. It is involved in the biological process described with: protein deglycosylation; mannose metabolic process. (1007 aa)
Mal-B1Maltase B1; Maltose alpha-glucosidase activity. It is involved in the biological process described with: carbohydrate metabolic process. (584 aa)
Npc2cNiemann-Pick type C-2c; Sterol binding. It is involved in the biological process described with: sterol transport; intracellular cholesterol transport. (165 aa)
Npc2dNiemann-Pick type C-2d; Sterol binding. It is involved in the biological process described with: sterol transport; intracellular cholesterol transport. (173 aa)
FanclFancl, isoform A; Fancl (Fancl) encodes a member of the Fanconi anemia pathway, which is a key mediator of DNA damage repair through homologous recombination. When mono-ubiquinated by the Fanconi core complex, it associates with the product of Fancd2 and localizes to sites of DNA damage. (381 aa)
Npc2bNiemann-Pick type C-2b, isoform A; Sterol binding. It is involved in the biological process described with: multicellular organism reproduction; ecdysteroid biosynthetic process; intracellular cholesterol transport; sterol transport. (159 aa)
Hr96Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis; Belongs to the nuclear hormone receptor family. NR1 subfamily. (723 aa)
CG15533Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (692 aa)
CG15534Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (666 aa)
Npc2hNiemann-Pick type C-2h (Npc2h) encodes a protein involved in immune signaling via interaction with lipopolysaccharides, lipid A, peptidoglycan and lipoteichoic acid. (157 aa)
Npc2gNiemann-Pick type C-2g, isoform A; Sterol binding. It is involved in the biological process described with: intracellular cholesterol transport; sterol transport; mesoderm development. (159 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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