node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arr2 | Galphaq | FBpp0076326 | FBpp0305314 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | 0.757 |
Arr2 | Gbeta5 | FBpp0076326 | FBpp0071137 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | RH17413p; GTPase activator activity; G-protein gamma-subunit binding. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; positive regulation of GTPase activity. | 0.504 |
Arr2 | inaD | FBpp0076326 | FBpp0293662 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Inactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. | 0.961 |
Arr2 | ninaC | FBpp0076326 | FBpp0079064 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Neither inactivation nor afterpotential protein C; Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities. Essential for the expression and stability of the rtp protein in the photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina. | 0.993 |
Arr2 | ninaE | FBpp0076326 | FBpp0083266 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. | 0.999 |
Arr2 | norpA | FBpp0076326 | FBpp0290690 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] | 0.941 |
Arr2 | rtp | FBpp0076326 | FBpp0078467 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | MORN repeat-containing protein 4 homolog; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. Organizes rhabdomeric components to suppress random activation of the phototransduction cascade and thus increases the signaling fidelity of dark-adapted photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina. | 0.695 |
Arr2 | trpl | FBpp0076326 | FBpp0087557 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Transient-receptor-potential-like protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins. | 0.966 |
Galphaq | Arr2 | FBpp0305314 | FBpp0076326 | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 0.757 |
Galphaq | Gbeta5 | FBpp0305314 | FBpp0071137 | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | RH17413p; GTPase activator activity; G-protein gamma-subunit binding. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; positive regulation of GTPase activity. | 0.969 |
Galphaq | inaD | FBpp0305314 | FBpp0293662 | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | Inactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. | 0.971 |
Galphaq | ninaC | FBpp0305314 | FBpp0079064 | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | Neither inactivation nor afterpotential protein C; Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities. Essential for the expression and stability of the rtp protein in the photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina. | 0.968 |
Galphaq | ninaE | FBpp0305314 | FBpp0083266 | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. | 0.976 |
Galphaq | norpA | FBpp0305314 | FBpp0290690 | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] | 0.993 |
Galphaq | rtp | FBpp0305314 | FBpp0078467 | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | MORN repeat-containing protein 4 homolog; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. Organizes rhabdomeric components to suppress random activation of the phototransduction cascade and thus increases the signaling fidelity of dark-adapted photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina. | 0.430 |
Galphaq | trpl | FBpp0305314 | FBpp0087557 | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | Transient-receptor-potential-like protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins. | 0.952 |
Gbeta5 | Arr2 | FBpp0071137 | FBpp0076326 | RH17413p; GTPase activator activity; G-protein gamma-subunit binding. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; positive regulation of GTPase activity. | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 0.504 |
Gbeta5 | Galphaq | FBpp0071137 | FBpp0305314 | RH17413p; GTPase activator activity; G-protein gamma-subunit binding. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; positive regulation of GTPase activity. | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | 0.969 |
Gbeta5 | inaD | FBpp0071137 | FBpp0293662 | RH17413p; GTPase activator activity; G-protein gamma-subunit binding. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; positive regulation of GTPase activity. | Inactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. | 0.439 |
Gbeta5 | norpA | FBpp0071137 | FBpp0290690 | RH17413p; GTPase activator activity; G-protein gamma-subunit binding. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; positive regulation of GTPase activity. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] | 0.896 |