(16 nodes) (2010) Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans. network (Drosophila melanogaster)

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	PKD	Protein Kinase D (PKD) encodes a Ser/Thr kinase of the PKC family of Ca[2+]/calmodulin-dependent protein kinases. It regulates actin-dynamics by controlling the activity of the phosphatase encoded by ssh. (906 aa)
	cep290	Centrosomal protein cep290; Essential for ciliogenesis in sensory neurons and germ cells. During neuron and spermatocyte ciliogenesis, plays a role in transition zone assembly where it is required for the formation of diverse connections between microtubules and between microtubules and the membrane. (1978 aa)
	IFT57	Intraflagellar transport protein 57 homolog; Required for the formation of cilia; Belongs to the IFT57 family. (405 aa)
	nompB	No mechanoreceptor potential B (nompB) encodes an essential component of the conserved intraflagellar transport mechanism, which is needed to extend cilia above the cell surface. nompB mutants have truncated, nonfunctional sensory cilia with consequent mechanosensory deficits. (857 aa)
	rempA	Reduced mechanoreceptor potential A (rempA) encodes the IFT140 subunit of the IFT-A subcomplex. As such, it is a component of the conserved intraflagellar transport (IFT) mechanism and is needed to extend cilia above the cell surface. (1503 aa)
	IFT52	Intraflagellar transport 52. (410 aa)
	Pkd2	Polycystic kidney disease 2 (Pkd2) encodes a calcium permeable cation channel of the transient receptor potential (TRP) family. Its roles include sperm motility, smooth muscle contraction, larval feeding behavior, detection of mechanical stimuli and cold nociception. (924 aa)
	iav	Inactive (iav) encodes a protein involved in the response to different stimuli such as startle, heat or sound; Belongs to the transient receptor (TC 1.A.4) family. (1123 aa)
	Rab8	Rab8, isoform A; Rab8 (Rab8) encodes a member of the Rab GTPase family that regulates the function of the recycling endosome, where it localizes. (207 aa)
	Arl1	ADP-ribosylation factor-like protein 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. (180 aa)
	BBS1	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly. (605 aa)
	dnd	Dead end (dnd) encodes an Arf-like3 GTPase that controls the targeting of exocytosis machinery to specific apical domains in fusion cells during the tracheal branch fusion process. (179 aa)
	Rnb	LD33331p; It is involved in the biological process described with: regulation of circadian rhythm. (975 aa)
	betaTub56D	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (456 aa)
	lin	Protein lines; Has a dual role as a segment polarity protein and as a modulator of the Abd-B protein. Required for Abd-B to activate the transcription of genes (including ems, cut and sal) that are involved in posterior spiracle morphogenesis. Also required for Abd-B to form an eighth abdominal denticle belt. Acts in a hierarchy downstream of drm and upstream of bowl during foregut and hindgut patterning and morphogenesis. Involved in cell rearrangement during elongation of the embryonic hindgut. Required to regulate expression of embryonic hindgut patterning genes in order to establis [...] (858 aa)
	Cc2d2a	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity). (1336 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Arl1	BBS1	FBpp0075272	FBpp0076621	ADP-ribosylation factor-like protein 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	0.573
Arl1	Rab8	FBpp0075272	FBpp0074690	ADP-ribosylation factor-like protein 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.	Rab8, isoform A; Rab8 (Rab8) encodes a member of the Rab GTPase family that regulates the function of the recycling endosome, where it localizes.	0.491
Arl1	nompB	FBpp0075272	FBpp0309502	ADP-ribosylation factor-like protein 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.	No mechanoreceptor potential B (nompB) encodes an essential component of the conserved intraflagellar transport mechanism, which is needed to extend cilia above the cell surface. nompB mutants have truncated, nonfunctional sensory cilia with consequent mechanosensory deficits.	0.468
BBS1	Arl1	FBpp0076621	FBpp0075272	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	ADP-ribosylation factor-like protein 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.	0.573
BBS1	Cc2d2a	FBpp0076621	FBpp0298338	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).	0.638
BBS1	IFT52	FBpp0076621	FBpp0078962	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	Intraflagellar transport 52.	0.829
BBS1	IFT57	FBpp0076621	FBpp0077218	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	Intraflagellar transport protein 57 homolog; Required for the formation of cilia; Belongs to the IFT57 family.	0.813
BBS1	Pkd2	FBpp0076621	FBpp0079947	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	Polycystic kidney disease 2 (Pkd2) encodes a calcium permeable cation channel of the transient receptor potential (TRP) family. Its roles include sperm motility, smooth muscle contraction, larval feeding behavior, detection of mechanical stimuli and cold nociception.	0.590
BBS1	Rab8	FBpp0076621	FBpp0074690	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	Rab8, isoform A; Rab8 (Rab8) encodes a member of the Rab GTPase family that regulates the function of the recycling endosome, where it localizes.	0.821
BBS1	cep290	FBpp0076621	FBpp0304992	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	Centrosomal protein cep290; Essential for ciliogenesis in sensory neurons and germ cells. During neuron and spermatocyte ciliogenesis, plays a role in transition zone assembly where it is required for the formation of diverse connections between microtubules and between microtubules and the membrane.	0.880
BBS1	dnd	FBpp0076621	FBpp0083549	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	Dead end (dnd) encodes an Arf-like3 GTPase that controls the targeting of exocytosis machinery to specific apical domains in fusion cells during the tracheal branch fusion process.	0.735
BBS1	nompB	FBpp0076621	FBpp0309502	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	No mechanoreceptor potential B (nompB) encodes an essential component of the conserved intraflagellar transport mechanism, which is needed to extend cilia above the cell surface. nompB mutants have truncated, nonfunctional sensory cilia with consequent mechanosensory deficits.	0.924
BBS1	rempA	FBpp0076621	FBpp0077738	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	Reduced mechanoreceptor potential A (rempA) encodes the IFT140 subunit of the IFT-A subcomplex. As such, it is a component of the conserved intraflagellar transport (IFT) mechanism and is needed to extend cilia above the cell surface.	0.820
Cc2d2a	BBS1	FBpp0298338	FBpp0076621	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).	Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.	0.638
Cc2d2a	IFT52	FBpp0298338	FBpp0078962	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).	Intraflagellar transport 52.	0.536
Cc2d2a	IFT57	FBpp0298338	FBpp0077218	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).	Intraflagellar transport protein 57 homolog; Required for the formation of cilia; Belongs to the IFT57 family.	0.730
Cc2d2a	Rab8	FBpp0298338	FBpp0074690	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).	Rab8, isoform A; Rab8 (Rab8) encodes a member of the Rab GTPase family that regulates the function of the recycling endosome, where it localizes.	0.469
Cc2d2a	cep290	FBpp0298338	FBpp0304992	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).	Centrosomal protein cep290; Essential for ciliogenesis in sensory neurons and germ cells. During neuron and spermatocyte ciliogenesis, plays a role in transition zone assembly where it is required for the formation of diverse connections between microtubules and between microtubules and the membrane.	0.975
Cc2d2a	dnd	FBpp0298338	FBpp0083549	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).	Dead end (dnd) encodes an Arf-like3 GTPase that controls the targeting of exocytosis machinery to specific apical domains in fusion cells during the tracheal branch fusion process.	0.509
Cc2d2a	nompB	FBpp0298338	FBpp0309502	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).	No mechanoreceptor potential B (nompB) encodes an essential component of the conserved intraflagellar transport mechanism, which is needed to extend cilia above the cell surface. nompB mutants have truncated, nonfunctional sensory cilia with consequent mechanosensory deficits.	0.821