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dre4 dre4 tipE tipE dob dob Rh4 Rh4 Nplp3 Nplp3 retinin retinin CG8745 CG8745 SP SP CG11425 CG11425 Acp26Aa Acp26Aa wg wg NimB4 NimB4 sNPF sNPF phu phu lsn lsn Hsp68 Hsp68 Obp99a Obp99a Obp99c Obp99c GstE1 GstE1 lectin-46Ca lectin-46Ca Crk Crk AANAT1 AANAT1 DopEcR DopEcR seq seq BG642312 BG642312 CG6910 CG6910 lectin-46Cb lectin-46Cb CG17575 CG17575 DOR DOR NaCP60E NaCP60E bru3 bru3 Obp99b Obp99b pHCl-1 pHCl-1 cpx cpx CG9997 CG9997 SPR SPR Acp36DE Acp36DE Lsp2 Lsp2 Lsp1beta Lsp1beta Hsp26 Hsp26 CG3348 CG3348 Ilp5 Ilp5 orb2 orb2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dre4FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1122 aa)
tipEProtein tipE; Enhances para sodium channel function. Required during pupal development to rescue adult paralysis and also protects adult flies against heat-induced lethality. (452 aa)
dobDoppelganger von brummer; Triglyceride lipase activity. It is involved in the biological process described with: lipid homeostasis; triglyceride catabolic process. (480 aa)
Rh4Opsin Rh4; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (378 aa)
Nplp3Neuropeptide-like 3; Neuropeptide hormone activity. It is involved in the biological process described with: neuropeptide signaling pathway. (90 aa)
retininRetinin; Structural constituent of eye lens. (191 aa)
CG8745Alanine--glyoxylate aminotransferase 2-like; Ethanolamine-phosphate phospho-lyase activity; transaminase activity; pyridoxal phosphate binding. It is involved in the biological process described with: response to nicotine. (494 aa)
SPAccessory gland-specific peptide 70A; Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila. Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors. Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial pe [...] (55 aa)
CG11425GH04282p; Lipid phosphatase activity; phosphatidate phosphatase activity; phosphatase activity. It is involved in the biological process described with: phospholipid dephosphorylation; phospholipid metabolic process; signal transduction. (305 aa)
Acp26AaAccessory gland protein 26Aa (Acp26Aa) encodes a protein synthesized in male accessory glands. It is transferred during mating to females where it induces an increase in ovulation by relaxing the oviduct via activation of octopaminergic signaling. (264 aa)
wgProtein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] (468 aa)
NimB4Nimrod B4; It is involved in the biological process described with: defense response to bacterium. (448 aa)
sNPFShort neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. (281 aa)
phuAlkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation; response to hypoxia; response to nicotine. (546 aa)
lsnVacuolar-sorting protein SNF8; Larsen (lsn), also known as Vacuolar protein sorting 22, encodes a member of the ESCRT-II complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, it also has a role in bcd RNA localization. (254 aa)
Hsp68Heat shock protein 68 (Hsp68) encodes a protein involved in lifespan determination and response to heat shock and starvation. (635 aa)
Obp99aGeneral odorant-binding protein 99a; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (142 aa)
Obp99cOdorant-binding protein 99c, isoform A; Odorant binding. It is involved in the biological process described with: response to fungus; sensory perception of smell; sensory perception of chemical stimulus. (151 aa)
GstE1Glutathione S transferase E1 (GstE1) encodes an enzyme involved in glutathione metabolic processes and response to heat. (224 aa)
lectin-46Calectin-46Ca (lectin-46Ca) encodes a protein with homology to C-type lectins. It is produced in the male accessory gland and transferred to females during mating. In mated females, it binds to sperm in the seminal receptacle. It is required for the binding of the product of SP to sperm, and for maintenance of long-term post-mating responses. (328 aa)
CrkAdapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family. (271 aa)
AANAT1Dopamine N-acetyltransferase; Catalyzes N-acetylation of tryptamine, tyramine, dopamine, serotonin and octopamine. Is not essential for sclerotization. (275 aa)
DopEcRDopamine/Ecdysteroid receptor (DopEcR) encodes a GPCR that shows ligand-biased activation. It can be activated by dopamine to increase cyclic AMP levels and by the insect steroid ecdysone to activate the MAPKinase pathway. It is widely expressed in the nervous system and can modulate a wide variety of complex behaviors including male courtship, locomotion, the response to stressful social interactions and the regulation of appetite. (322 aa)
seqSequoia, isoform A; Sequoia (seq) encodes a pan-neuronally expressed zinc-finger transcription factor that governs dendrite and axon outgrowth. It is necessary for the proper development of tracheal branches and dendritic branches of multidendritic neurons, as well as development of the R8 cell in eye development. (882 aa)
BG642312BG642312, isoform A; BG642312 (BG642312) encodes a peptide produced in the male accessory glands and transferred to females during mating. (77 aa)
CG6910RH44796p; Inositol oxygenase activity; iron ion binding. It is involved in the biological process described with: oxidation-reduction process; inositol catabolic process. (292 aa)
lectin-46Cblectin-46Cb (lectin-46Cb) encodes a protein with homology to C-type lectins. It is produced in the male accessory gland and transferred to females during mating. In mated females, is required for the binding of product of SP to sperm, and for maintenance of long-term post-mating responses. (322 aa)
CG17575Uncharacterized protein, isoform B; CG17575 encodes a cysteine-rich secretory protein produced in the male accessory glands and transferred to females during mating. In mated females, it is required for the binding of the product of SP to sperm and for the consequent maintenance of long-term post-mating responses. (298 aa)
DORDiabetes and obesity regulated (DOR) encodes a transcriptional coactivator of ecdysone receptor signaling required during metamorphosis. It is antagonized by insulin signaling via the product of foxo in the fat body and forms part of a feed-forward mechanism whereby ecdysone potentiates its own signaling. The product of DOR also regulates autophagosome formation and protein degradation via ecdysone signaling. (417 aa)
NaCP60ENa channel protein 60E (NaCP60E) encodes a voltage-gated calcium-selective cation channel that likely modulates the stability of neural circuits, particularly under environmental stresses; Belongs to the sodium channel (TC 1.A.1.10) family. NaCP60E subfamily. (2896 aa)
bru3Bruno 3 (bru3) encodes an RNA binding protein that binds to the EDEN element and mediates maternal mRNA translational repression. (422 aa)
Obp99bGeneral odorant-binding protein 99b; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (149 aa)
pHCl-1pH-sensitive chloride channel 1 (pHCl-1) encodes a protein involved in chloride transmembrane transport; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (978 aa)
cpxComplexin (cpx) encodes a presynaptic cytosolic protein that regulates SNARE complex assembly and fuction. It has both positive and negative roles in synaptic transmission, serving as the synaptic vesicle fusion clamp and as an activator of evoked release; Belongs to the complexin/synaphin family. (157 aa)
CG9997Uncharacterized protein, isoform A; CG9997 encodes a protein with homology to serine-type endopeptidases, but is not predicted to have catalytic activity due to mutations in its active site. It is produced in the male accessory gland and transferred to females during mating. In males, it is required for other seminal proteins to be transferred to mated females. In mated females, it is required for the binding of the product of SP to sperm and for the maintenance of long-term post-mating responses. (330 aa)
SPRSex peptide receptor; Receptor for two functionally unrelated ligands; SP (A70A) for controlling reproductive behaviors and MIP for controlling sleep behavior. MIP-SPR pathway functions as a sleep homeostat which perceives the need for sleep and stabilizes it by providing a slow-acting inhibitory input to the fly arousal system that involve the pigment dispersing factor (pdf) neurons. SP-SPR is one of the multiple SP pathways that induce female post- mating behavioral responses (PMR) such as the suppression of mating receptivity and initiation of egg laying. The PMR switch is achieved [...] (435 aa)
Acp36DEAccessory gland protein Acp36DE; Responsible for physiological and behavioral changes in mated female flies. Associates with sperm and localizes to specific regions of the female reproductive tract, including the sperm storage organs. It accelerates sperm accumulation into storage but does not mediate the entry of the first sperm into storage. Once sperm storage has initiated it seems to act as a guidance factor helping subsequent sperm move into storage, a corral concentrating sperm around the SSO entrances and/or a trigger for responses within the female that accelerate storage of sperm. (912 aa)
Lsp2Larval serum protein 2; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins. (701 aa)
Lsp1betaLarval serum protein 1 beta chain; Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins; Belongs to the hemocyanin family. (789 aa)
Hsp26Heat shock protein 26 (Hsp26) encodes a protein involved in protein folding. It contributes to lifespan determination and the response to cold and heat. (208 aa)
CG3348GEO07187p1; Chitin binding. It is involved in the biological process described with: chitin metabolic process. (98 aa)
Ilp5Insulin-like peptide 5 (Ilp5) encodes a peptide involved in the insulin signaling pathway, sleep and mating behavior in females; Belongs to the insulin family. (108 aa)
orb2Translational regulator orb2; Required in mushroom body gamma neurons for long-term memory in male courtship. Binds to mRNA 3'- UTRs. In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover. In its amyloid- like oligomeric form, acts as a translational activator. The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA. Isoform A is required for initial memory acquisition and, following subsequent late dopaminerg [...] (769 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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