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Rheb Rheb Ilp6 Ilp6 Ilp7 Ilp7 Alp2 Alp2 Alp7 Alp7 Pi3K59F Pi3K59F Alp11 Alp11 btl btl Ilp2 Ilp2 Ilp4 Ilp4 Ilp3 Ilp3 Alp10 Alp10 slif slif Scox Scox Dfd Dfd phu phu Alp5 Alp5 InR InR Tsc1 Tsc1 Alp4 Alp4 Dcr-2 Dcr-2 Diap2 Diap2 Alp6 Alp6 Pten Pten foxo foxo elav elav Alp13 Alp13 Dop1R1 Dop1R1 Pi3K21B Pi3K21B nSyb nSyb Alp1 Alp1 Pdk1 Pdk1 shi shi Alp12 Alp12 Tor Tor Alp8 Alp8 Alp9 Alp9 Ilp5 Ilp5 ras ras
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RhebGTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity (By similarity). Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K through activation of TORC1 signaling. May also have a role in activating TORC2 signaling. (182 aa)
Ilp6Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation. (107 aa)
Ilp7Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth. (159 aa)
Alp2Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (538 aa)
Alp7Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (543 aa)
Pi3K59FPhosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. (949 aa)
Alp11Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (483 aa)
btlFibroblast growth factor receptor homolog 2; May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues. (1052 aa)
Ilp2Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. (137 aa)
Ilp4Insulin-like peptide 4 (Ilp4) encodes a protein involved in larval feeding behavior; Belongs to the insulin family. (134 aa)
Ilp3Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females. (120 aa)
Alp10Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (524 aa)
slifSlimfast, isoform A; L-ornithine transmembrane transporter activity; L-lysine transmembrane transporter activity; arginine transmembrane transporter activity; basic amino acid transmembrane transporter activity; amino acid transmembrane transporter activity. (604 aa)
ScoxSynthesis of cytochrome c oxidase (Scox) encodes a protein involved in cytochrome complex assembly and regulation of ATP biosynthesis. (251 aa)
DfdHomeotic protein deformed; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Homeotic protein controlling Drosophila head development. Transcriptional activator of the apoptotic activator protein rpr in cells at the maxillary/mandibular boundary; Belongs to the Antp homeobox family. Deformed subfamily. (586 aa)
phuAlkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation; response to hypoxia; response to nicotine. (546 aa)
Alp5Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (522 aa)
InRInsulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa)
Tsc1LD23779p; Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. (1100 aa)
Alp4Alkaline phosphatase 4; Important role in neural and renal epithelial function. (596 aa)
Dcr-2Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. (1722 aa)
Diap2Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] (498 aa)
Alp6Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (515 aa)
PtenPhosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. (514 aa)
foxoForkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (622 aa)
elavProtein elav; Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism. Belongs to the RRM elav family. (483 aa)
Alp13Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (479 aa)
Dop1R1Dopamine receptor 1; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role i [...] (560 aa)
Pi3K21BPi3K21B, isoform B; Pi3K21B (Pi3K21B) encodes an adaptor protein (p60) that binds the product of Pi3K92E to form the functional cllass IA phosphoinositide 3-kinase. This heterodimeric kinase is involved in phosphatidylinositol phosphorylation and regulates cell size and proliferation. (496 aa)
nSybNeuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion. (206 aa)
Alp1Alkaline phosphatase 1, isoform B; Alkaline phosphatase 1 (Alp1) encodes an alkaline phosphatase. Alkaline phosphatases catalyze the hydrolysis of monoesters of phosphoric acid and a transphosphorylation reaction in the presence of large concentrations of phosphate acceptors. (530 aa)
Pdk13-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (836 aa)
shiDynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (896 aa)
Alp12Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (596 aa)
TorSerine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] (2471 aa)
Alp8Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (533 aa)
Alp9Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation. (517 aa)
Ilp5Insulin-like peptide 5 (Ilp5) encodes a peptide involved in the insulin signaling pathway, sleep and mating behavior in females; Belongs to the insulin family. (108 aa)
rasInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (590 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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