9 items (Drosophila melanogaster) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	eIF4E7	Eukaryotic translation initiation factor 4E7 (eIF4E7) encodes a protein involved in translational initiation. (429 aa)
	eIF4E3	Eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability. (244 aa)
	eIF4E5	Eukaryotic translation initiation factor 4E5 (eIF4E5) encodes a protein in translational initiation. (232 aa)
	eIF4E4	Eukaryotic translation initiation factor 4E4 (eIF4E4) encodes a protein involved in translational initiation. (229 aa)
	GluRIIA	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (907 aa)
	GluRIIB	Glutamate receptor IIB (GluRIIB) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (913 aa)
	eIF4E6	Eukaryotic translation initiation factor 4E6 (eIF4E6) encodes a RNA 7-methylguanosine cap binding protein. (173 aa)
	eIF4E1	Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family. (259 aa)
	GluRIIC	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. (940 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GluRIIA	GluRIIB	FBpp0078739	FBpp0088541	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	Glutamate receptor IIB (GluRIIB) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	0.948
GluRIIA	GluRIIC	FBpp0078739	FBpp0307912	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission.	0.835
GluRIIA	eIF4E1	FBpp0078739	FBpp0306017	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family.	0.401
GluRIIA	eIF4E3	FBpp0078739	FBpp0076424	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	Eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability.	0.401
GluRIIA	eIF4E5	FBpp0078739	FBpp0076464	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	Eukaryotic translation initiation factor 4E5 (eIF4E5) encodes a protein in translational initiation.	0.400
GluRIIA	eIF4E7	FBpp0078739	FBpp0070242	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	Eukaryotic translation initiation factor 4E7 (eIF4E7) encodes a protein involved in translational initiation.	0.400
GluRIIB	GluRIIA	FBpp0088541	FBpp0078739	Glutamate receptor IIB (GluRIIB) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	0.948
GluRIIB	GluRIIC	FBpp0088541	FBpp0307912	Glutamate receptor IIB (GluRIIB) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission.	0.914
GluRIIC	GluRIIA	FBpp0307912	FBpp0078739	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission.	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	0.835
GluRIIC	GluRIIB	FBpp0307912	FBpp0088541	Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission.	Glutamate receptor IIB (GluRIIB) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	0.914
eIF4E1	GluRIIA	FBpp0306017	FBpp0078739	Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family.	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	0.401
eIF4E1	eIF4E3	FBpp0306017	FBpp0076424	Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family.	Eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability.	0.828
eIF4E1	eIF4E4	FBpp0306017	FBpp0076672	Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family.	Eukaryotic translation initiation factor 4E4 (eIF4E4) encodes a protein involved in translational initiation.	0.823
eIF4E1	eIF4E5	FBpp0306017	FBpp0076464	Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family.	Eukaryotic translation initiation factor 4E5 (eIF4E5) encodes a protein in translational initiation.	0.824
eIF4E1	eIF4E6	FBpp0306017	FBpp0291677	Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family.	Eukaryotic translation initiation factor 4E6 (eIF4E6) encodes a RNA 7-methylguanosine cap binding protein.	0.826
eIF4E1	eIF4E7	FBpp0306017	FBpp0070242	Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family.	Eukaryotic translation initiation factor 4E7 (eIF4E7) encodes a protein involved in translational initiation.	0.825
eIF4E3	GluRIIA	FBpp0076424	FBpp0078739	Eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability.	Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.	0.401
eIF4E3	eIF4E1	FBpp0076424	FBpp0306017	Eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability.	Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family.	0.828
eIF4E3	eIF4E4	FBpp0076424	FBpp0076672	Eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability.	Eukaryotic translation initiation factor 4E4 (eIF4E4) encodes a protein involved in translational initiation.	0.850
eIF4E3	eIF4E5	FBpp0076424	FBpp0076464	Eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability.	Eukaryotic translation initiation factor 4E5 (eIF4E5) encodes a protein in translational initiation.	0.935