8 items (Drosophila melanogaster) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pasha	Partner of drosha (pasha) encodes a protein involved in oogenesis and miRNA processing. (642 aa)
	ubl	Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process. (73 aa)
	CG31528	FI07626p; Polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process. (344 aa)
	Ranbp21	Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus. (1241 aa)
	Ubqn	Ubiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy. (547 aa)
	Vmat	Vesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles. (646 aa)
	drosha	Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. (1327 aa)
	Dcr-2	Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. (1722 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG31528	Ubqn	FBpp0078563	FBpp0309477	FI07626p; Polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process.	Ubiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy.	0.922
CG31528	ubl	FBpp0078563	FBpp0085529	FI07626p; Polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process.	Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process.	0.528
Dcr-2	Ranbp21	FBpp0086061	FBpp0309478	Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.	Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus.	0.986
Dcr-2	drosha	FBpp0086061	FBpp0087926	Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.	Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development.	0.988
Dcr-2	pasha	FBpp0086061	FBpp0085181	Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.	Partner of drosha (pasha) encodes a protein involved in oogenesis and miRNA processing.	0.999
Ranbp21	Dcr-2	FBpp0309478	FBpp0086061	Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus.	Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.	0.986
Ranbp21	drosha	FBpp0309478	FBpp0087926	Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus.	Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development.	0.990
Ranbp21	pasha	FBpp0309478	FBpp0085181	Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus.	Partner of drosha (pasha) encodes a protein involved in oogenesis and miRNA processing.	0.990
Ubqn	CG31528	FBpp0309477	FBpp0078563	Ubiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy.	FI07626p; Polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process.	0.922
Ubqn	ubl	FBpp0309477	FBpp0085529	Ubiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy.	Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process.	0.845
drosha	Dcr-2	FBpp0087926	FBpp0086061	Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development.	Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.	0.988
drosha	Ranbp21	FBpp0087926	FBpp0309478	Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development.	Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus.	0.990
drosha	pasha	FBpp0087926	FBpp0085181	Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development.	Partner of drosha (pasha) encodes a protein involved in oogenesis and miRNA processing.	0.999
pasha	Dcr-2	FBpp0085181	FBpp0086061	Partner of drosha (pasha) encodes a protein involved in oogenesis and miRNA processing.	Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.	0.999
pasha	Ranbp21	FBpp0085181	FBpp0309478	Partner of drosha (pasha) encodes a protein involved in oogenesis and miRNA processing.	Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus.	0.990
pasha	drosha	FBpp0085181	FBpp0087926	Partner of drosha (pasha) encodes a protein involved in oogenesis and miRNA processing.	Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development.	0.999
ubl	CG31528	FBpp0085529	FBpp0078563	Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process.	FI07626p; Polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process.	0.528
ubl	Ubqn	FBpp0085529	FBpp0309477	Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process.	Ubiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy.	0.845