node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Eph | Ephrin | FBpp0088153 | FBpp0088146 | Eph receptor tyrosine kinase (Eph) encodes an axon guidance molecule involved in the development of the nervous system. It also contributes to shaping the antero-posterior compartment boundary of the wing disc. | Ephrin, isoform A; Ephrin (Ephrin) encodes the ligand of the product of Eph. It is involved in nervous system development; Belongs to the ephrin family. | 0.999 |
Ephrin | Eph | FBpp0088146 | FBpp0088153 | Ephrin, isoform A; Ephrin (Ephrin) encodes the ligand of the product of Eph. It is involved in nervous system development; Belongs to the ephrin family. | Eph receptor tyrosine kinase (Eph) encodes an axon guidance molecule involved in the development of the nervous system. It also contributes to shaping the antero-posterior compartment boundary of the wing disc. | 0.999 |
Jra | kay | FBpp0303456 | FBpp0288515 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Plays a role in dorsal closure. Belongs to the bZIP family. Jun subfamily. | Transcription factor kayak, isoforms A/B/F; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra. Belongs to the bZIP family. Fos subfamily. | 0.999 |
Jra | p38a | FBpp0303456 | FBpp0083966 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Plays a role in dorsal closure. Belongs to the bZIP family. Jun subfamily. | P38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. | 0.862 |
S6k | Skp2 | FBpp0305462 | FBpp0078593 | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. | S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues. | 0.406 |
S6k | betaTub56D | FBpp0305462 | FBpp0085721 | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | 0.472 |
S6k | p38a | FBpp0305462 | FBpp0083966 | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. | P38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. | 0.494 |
Skp2 | S6k | FBpp0078593 | FBpp0305462 | S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues. | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. | 0.406 |
Skp2 | Uba1 | FBpp0078593 | FBpp0087583 | S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues. | Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. | 0.568 |
Skp2 | p38a | FBpp0078593 | FBpp0083966 | S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues. | P38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. | 0.420 |
Uba1 | Skp2 | FBpp0087583 | FBpp0078593 | Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. | S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues. | 0.568 |
betaTub56D | S6k | FBpp0085721 | FBpp0305462 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. | 0.472 |
betaTub56D | hiw | FBpp0085721 | FBpp0311921 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | E3 ubiquitin-protein ligase highwire; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromu [...] | 0.450 |
betaTub56D | p38a | FBpp0085721 | FBpp0083966 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | P38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. | 0.441 |
hiw | betaTub56D | FBpp0311921 | FBpp0085721 | E3 ubiquitin-protein ligase highwire; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromu [...] | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | 0.450 |
hiw | kay | FBpp0311921 | FBpp0288515 | E3 ubiquitin-protein ligase highwire; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromu [...] | Transcription factor kayak, isoforms A/B/F; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra. Belongs to the bZIP family. Fos subfamily. | 0.439 |
kay | Jra | FBpp0288515 | FBpp0303456 | Transcription factor kayak, isoforms A/B/F; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra. Belongs to the bZIP family. Fos subfamily. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Plays a role in dorsal closure. Belongs to the bZIP family. Jun subfamily. | 0.999 |
kay | hiw | FBpp0288515 | FBpp0311921 | Transcription factor kayak, isoforms A/B/F; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra. Belongs to the bZIP family. Fos subfamily. | E3 ubiquitin-protein ligase highwire; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromu [...] | 0.439 |
kay | p38a | FBpp0288515 | FBpp0083966 | Transcription factor kayak, isoforms A/B/F; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra. Belongs to the bZIP family. Fos subfamily. | P38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. | 0.641 |
p38a | Jra | FBpp0083966 | FBpp0303456 | P38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Plays a role in dorsal closure. Belongs to the bZIP family. Jun subfamily. | 0.862 |