STRINGSTRING
Herc4 Herc4 Cdc6 Cdc6 Syx8 Syx8 gig gig mus101 mus101 Eip63F-1 Eip63F-1 CG13898 CG13898 CG13526 CG13526 CG5024 CG5024 CG17770 CG17770 CG5984 CG5984 Gp93 Gp93 azot azot CG30378 CG30378 Cyt-b5 Cyt-b5 Chc Chc Ank Ank Nedd4 Nedd4 ctrip ctrip Acam Acam Ank2 Ank2 Cam Cam Dro Dro CG31960 CG31960 jbug jbug Smurf Smurf Ufd4 Ufd4 strat strat Skp2 Skp2 Arf79F Arf79F Su(dx) Su(dx)
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Herc4HECT and RLD domain containing E3 ubiquitin ligase 4 (Herc4) encodes a HECT-type E3 ubiquity ligase that is involved in the host defense against Gram-positive bacteria mediated by Toll pathway. (1062 aa)
Cdc6Cell division control protein; Cdc6 (Cdc6) encodes an essential component of the pre-Replication complex (preRC) together with the origin recognition complex, the product of dup and MCM2-7 proteins. The preRC is present at all chromosomal origins of replication and is required for the initiation of DNA replication. The product of Cdc6 also functions in the co-ordination of DNA replication with mitosis, and may contribute to apoptosis and transcription; Belongs to the CDC6/cdc18 family. (662 aa)
Syx8Syntaxin 8; SNAP receptor activity; SNARE binding. It is involved in the biological process described with: intracellular protein transport; synaptic vesicle docking; vesicle fusion; vesicle docking. (232 aa)
gigGigas, isoform A; Gigas (gig) encodes a tumour suppressor protein that, together with with the product of Tsc1, controls cellular growth via antagonizing insulin and TOR signalling pathways. (1847 aa)
mus101Mutagen-sensitive 101 (mus101) encodes a protein involved in the DNA replication checkpoint during mitosis. (1425 aa)
Eip63F-1Calcium-binding protein E63-1; Ecdysone-induced protein 63F 1 (Eip63F-1) encodes a member of the EF-hand family of Ca[2+]-binding proteins, induced directly by 20-hydroxyecdysone in late third instar larvae. It is responsible for formation of the 63F early puff in the polytene chromosomes. (193 aa)
CG13898GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. (151 aa)
CG13526Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. (154 aa)
CG5024GEO08667p1; Calcium ion binding; enzyme regulator activity. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization. (165 aa)
CG17770MIP05401p; Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization. (164 aa)
CG5984Uncharacterized protein; Actin binding. It is involved in the biological process described with: actin cytoskeleton organization; cell differentiation. (271 aa)
Gp93Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. (787 aa)
azotGEO08584p1; Ahuizotl (azot) encodes a calcium dependent protein that ensures the elimination of less fit cells. Fitness-based cell culling is used to maintain tissue health, delay aging, and extend lifespan. During development it also prevents malformations; Belongs to the calmodulin family. (148 aa)
CG30378Uncharacterized protein; Calcium ion binding. (148 aa)
Cyt-b5Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein which functions as an electron carrier for several membrane-bound oxygenases. (134 aa)
ChcClathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. (1678 aa)
AnkAnkyrin, isoform B; Ankyrin (Ank) encodes protein that is recruited to the plasma membrane by its association with the product of beta-Spec. It also binds to the adhesion protein encoded by Nrg leading to accumulation of the products of Ank and beta-Spec at sites of cell-cell adhesion. (1549 aa)
Nedd4E3 ubiquitin-protein ligase Nedd-4; Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down- regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation. (1007 aa)
ctripCircadian trip (ctrip) encodes a HECT ubiquitin ligase that regulates the levels and circadian oscillations of the transcriptional activator encoded by Clk. It plays a role in the control of rest-activity rhythms. (3140 aa)
AcamCalmodulin-related protein 97A; May be involved in calcium-mediated signal transduction. (148 aa)
Ank2Ankyrin 2, isoform U; Ankyrin 2 (Ank2) encodes a cytoskeletal binding protein required for proper function of the product of beta-Spec via direct interaction. It contributes to the regulation of short-term memory, sound perception, microtubule cytoskeleton and neuromuscular junction development and synapsis. (13559 aa)
CamCalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. (149 aa)
DroDrosocin (Dro) encodes an o-Glycosylated antibacterial peptide with activity against Gram-negative and Gram-positive bacteria. It is expressed in the fat body during the systemic immune response and is expressed in various epithelia. The expression of Dro is regulated at the transcriptional level mostly by the immune deficiency pathway; Belongs to the drosocin family. (64 aa)
CG31960GEO02651p1; Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization; Belongs to the calmodulin family. (148 aa)
jbugJitterbug, isoform N; Jitterbug (jbug) encodes a Filamin-type protein. Filamins are actin crosslinkers that organize actin filaments into networks and connect them to membrane receptors. The product of jbug is required in photoreceptor cells for axon targeting and in notum tendon cells to maintain its shape during muscle-tendon interaction. (2990 aa)
SmurfE3 ubiquitin-protein ligase Smurf1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation. (1061 aa)
Ufd4E3 ubiquitin-protein ligase Ufd4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Kcmf1 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. (2727 aa)
stratGuanine nucleotide exchange factor MSS4 homolog; Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily such as Rab8. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins such as trol/Pcan and vkg/Coll IV to the basal surface of follicular epithelial (FE) cells. Likely to function by restricting the activity of the vesicle transport regulator Rab8 to the basal membrane, and thus directs BM protein-containing vesicles to the basal side o [...] (122 aa)
Skp2S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues. (559 aa)
Arf79FADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; has a role in Golgi organization and may modulate vesicle budding and uncoating within the Golgi apparatus (Probable). Has a role in eye development. Required for cleavage furrow ingression in embryonic cells. (182 aa)
Su(dx)E3 ubiquitin-protein ligase Su(dx); E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation. (949 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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