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fh fh Alas Alas CG1275 CG1275 Fer3HCH Fer3HCH Irp-1B Irp-1B Irp-1A Irp-1A Mco3 Mco3 mfrn mfrn Tsf3 Tsf3 Def Def CG1358 CG1358 Hsc20 Hsc20 Ire1 Ire1 Mco1 Mco1 CG30345 CG30345 Mvl Mvl Fer2LCH Fer2LCH Fer1HCH Fer1HCH Hph Hph Tsf1 Tsf1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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fhFrataxin homolog, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the frataxin family. (190 aa)
AlasAminolevulinate synthase (Alas) encodes a mitochondrial enzyme involved in cuticle barrier formation and thought to have a role in Heme biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (539 aa)
CG1275LD36721p; Oxidoreductase activity; ferric-chelate reductase activity; metal ion binding. (340 aa)
Fer3HCHFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (186 aa)
Irp-1BIron regulatory protein 1B (Irp-1B) encodes a cytosolic aconitase highly homologous to the product of Irp-1A; Belongs to the aconitase/IPM isomerase family. (899 aa)
Irp-1AIron regulatory protein 1A (Irp-1A) encodes a cytosolic aconitase that under iron deficiency (or if cytosolic superoxide is present) loses its iron-sulfur cluster, changes confirmation and binds iron regulatory elements (so far identified on the products of SdhB and Fer1HCH mRNAs); Belongs to the aconitase/IPM isomerase family. (902 aa)
Mco3Multicopper oxidase 3 (Mco3) encodes a multi-copper oxidase enzyme that is located in the cellular secretory pathway. It is developmentally regulated and has been proposed to affect iron and copper homeostasis. (677 aa)
mfrnMitoferrin; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly; Belongs to the mitochondrial carrier (TC 2.A.29) family. (379 aa)
Tsf3Transferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (714 aa)
DefDefensin (Def) encodes an antibacterial peptide with activity against Gram-positive bacteria. It is induced in the fat body during the systemic immune response and is expressed in various epithelia. The expression of Def is regulated at the transcriptional level by both the immune deficiency and Toll pathways; Belongs to the invertebrate defensin family. Type 1 subfamily. (92 aa)
CG1358MIP14896p; Heme binding; heme transporter activity. It is involved in the biological process described with: heme export; transmembrane transport. (482 aa)
Hsc20Heat shock protein cognate 20 (Hsc20) encodes a mitochondrial chaperone that facilitates iron sulfur cluster assembly or transfer from the product of IscU to other scaffold proteins. Hsc20 is required for larval growth and cellular iron sensing. (240 aa)
Ire1Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation. (1074 aa)
Mco1Multicopper oxidase 1 (Mco1) encodes a plasma membrane-bound multicopper oxidase that is positioned to oxidize substrates in the hemolymph, such as ascorbate, and its biological role is unknown. (959 aa)
CG30345IP12271p; Transporter activity. It is involved in the biological process described with: transmembrane transport. (496 aa)
MvlMalvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn[2+] and Fe[2+]. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling. (639 aa)
Fer2LCHFerritin 2 light chain homologue (Fer2LCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer2LCH provides iron nucleation sites in the internal cavity of the complex required for iron mineralization and is essential for embryogenesis. (236 aa)
Fer1HCHFerritin 1 heavy chain homologue (Fer1HCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer1HCH has ferroxidase activity required for iron loading into ferritin and is essential for embryogenesis. (245 aa)
HphHIF prolyl hydroxylase (Hph) encodes the prolyl-4 hydroxylase that hydroxylases proline 850a of the product of sima, which is the alpha-subunit of the hypoxia inducible factor (HIF). The product of Hph regulates growth through both independent and dependent mechanisms of the product of sima. (478 aa)
Tsf1Transferrin 1 (Tsf1) encodes an iron binding protein induced during the immune response. Iron sequestration is a classical host defense mechanism to combat bacterial infection. (641 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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