6 items (Drosophila melanogaster) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ac	Achaete-scute complex protein T5; Achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development. (201 aa)
	nau	Nautilus (nau) encodes a protein that belongs to the bHLH family of transcription factors. It is the unique Drosophila ortholog of the mammalian family of bHLH Myogenic Regulatory Factors. It is involved in somatic muscle myogenesis. (332 aa)
	ato	Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection. (312 aa)
	sens	Zinc finger protein sens; Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination. (541 aa)
	mib1	E3 ubiquitin-protein ligase mind-bomb; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl- dependent signalin [...] (1226 aa)
	sc	Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation. (345 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ac	ato	FBpp0070071	FBpp0081318	Achaete-scute complex protein T5; Achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development.	Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection.	0.929
ac	sc	FBpp0070071	FBpp0070072	Achaete-scute complex protein T5; Achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development.	Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation.	0.997
ac	sens	FBpp0070071	FBpp0075596	Achaete-scute complex protein T5; Achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development.	Zinc finger protein sens; Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.	0.886
ato	ac	FBpp0081318	FBpp0070071	Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection.	Achaete-scute complex protein T5; Achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development.	0.929
ato	sc	FBpp0081318	FBpp0070072	Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection.	Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation.	0.967
ato	sens	FBpp0081318	FBpp0075596	Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection.	Zinc finger protein sens; Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.	0.960
sc	ac	FBpp0070072	FBpp0070071	Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation.	Achaete-scute complex protein T5; Achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development.	0.997
sc	ato	FBpp0070072	FBpp0081318	Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation.	Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection.	0.967
sc	sens	FBpp0070072	FBpp0075596	Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation.	Zinc finger protein sens; Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.	0.894
sens	ac	FBpp0075596	FBpp0070071	Zinc finger protein sens; Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.	Achaete-scute complex protein T5; Achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development.	0.886
sens	ato	FBpp0075596	FBpp0081318	Zinc finger protein sens; Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.	Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection.	0.960
sens	sc	FBpp0075596	FBpp0070072	Zinc finger protein sens; Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.	Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation.	0.894