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ABCD ABCD MRP MRP Atet Atet EcR EcR ABCA ABCA eEF1alpha1 eEF1alpha1 Hmt-1 Hmt-1 RpII140 RpII140 Sur Sur E23 E23 CG7794 CG7794 snu snu eEF1alpha2 eEF1alpha2 CG9010 CG9010 Mdr50 Mdr50 Mdr49 Mdr49 Gapdh1 Gapdh1 alphaTub85E alphaTub85E alphaTub84B alphaTub84B alphaTub84D alphaTub84D CG17646 CG17646 Mdr65 Mdr65 pix pix alphaTub67C alphaTub67C Gapdh2 Gapdh2 ABCB7 ABCB7 Tbp Tbp
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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ABCDATP-binding cassette sub-family D member; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation; Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. (730 aa)
MRPMultidrug-Resistance like protein 1, isoform A; ATPase activity; ATPase-coupled transmembrane transporter activity; ATP binding; ATPase-coupled inorganic anion transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; renal tubular secretion; response to toxic substance; anion transmembrane transport. (1549 aa)
AtetABC transporter expressed in trachea (Atet) encodes a protein that is involved in transmembrane transport. (832 aa)
EcREcdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. (878 aa)
ABCAATP binding cassette subfamily A, isoform B; ATPase activity; ATP binding; ATPase-coupled transmembrane transporter activity; lipid transporter activity. It is involved in the biological process described with: lipid transport; transmembrane transport. (1714 aa)
eEF1alpha1Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (463 aa)
Hmt-1Heavy metal tolerance factor 1; It is involved in the biological process described with: heme transport; transmembrane transport; response to cadmium ion. (866 aa)
RpII140DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...] (1176 aa)
SurATP-binding cassette sub-family C member Sur; May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP- sensitive inward rectifier potassium channel family (By similarity). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress. (2223 aa)
E23Early gene at 23, isoform C; ATP binding; ATPase-coupled transmembrane transporter activity; ATPase activity. It is involved in the biological process described with: regulation of circadian rhythm; transmembrane transport. (1017 aa)
CG7794AT04270p; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (455 aa)
snuSnustorr, isoform A; ATPase activity; ATP binding. It is involved in the biological process described with: cuticle development; transmembrane transport. (808 aa)
eEF1alpha2Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
CG9010Glyceraldehyde-3-phosphate dehydrogenase; Peptidyl-cysteine S-nitrosylase activity; NADP binding; NAD binding; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. It is involved in the biological process described with: oxidation-reduction process; glycolytic process; glucose metabolic process. (343 aa)
Mdr50Multi drug resistance 50; Efflux transmembrane transporter activity; ATPase-coupled xenobiotic transmembrane transporter activity; ATPase activity; ATPase-coupled transmembrane transporter activity; ATP binding. It is involved in the biological process described with: response to insecticide; response to toxic substance; xenobiotic transport; transmembrane transport; renal tubular secretion. (1313 aa)
Mdr49Multidrug resistance protein homolog 49; Multi drug resistance 49 (Mdr49) encodes drug transmembrane transporter that belongs to the ABCB transporter subfamily and contributes to insecticide resistance. (1302 aa)
Gapdh1Glyceraldehyde 3 phosphate dehydrogenase 1 (Gapdh1) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glycolysis, myoblast fusion and the development of somatic muscle. (332 aa)
alphaTub85ETubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
alphaTub84BTubulin alpha-1 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
alphaTub84DTubulin alpha-3 chain; alpha-Tubulin at 84D (alphaTub84D) encodes a protein involved in major cellular mechanisms such as formation of spindle apparatus or microtubular threads for transport of proteins or organelles. (450 aa)
CG17646SD03967p; ATPase activity; ATP binding; ATPase-coupled transmembrane transporter activity. It is involved in the biological process described with: triglyceride metabolic process; transmembrane transport. (766 aa)
Mdr65Multidrug resistance protein homolog 65; Multi drug resistance 65 (Mdr65) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in humoral/CNS barrier drug exclusion and response to insecticide; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1302 aa)
pixPixie, isoform A; Pixie (pix) encodes ABCE1, which is an ATPase that functions as a translation recycling factor. It is required for the assembly of complexes involved in translation initiation, and plays a role in the regulation of cellular and organismal growth. (611 aa)
alphaTub67CTubulin alpha-4 chain; alpha-Tubulin at 67C (alphaTub67C) encodes a protein that form heterodimers with beta-tubulins to polymerise and form microtubules. Tubulin molecules containing the product of alphaTub67C are essential for fast growth of the microtubules during the initial cleavage divisions of embryogenesis. (462 aa)
Gapdh2Glyceraldehyde 3 phosphate dehydrogenase 2 (Gapdh2) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glucose homeostasis; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
ABCB7ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis. (743 aa)
TbpTATA binding protein (Tbp) encodes a basal transcription factor required at most RNA Pol I and Pol II-transcribed genes. Traditionally thought to be recruited only to TATA box containing promoters, recent work shows that promoters with very weak TATA box consensus sequences also recruit the product of Tbp as a part of the multisubunit TFIID basal transcription factor or via the SAGA histone acetyltransferase complex. (353 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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