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Gr5a Gr5a Gr64f Gr64f OdsH OdsH Ir76b Ir76b Grasp65 Grasp65 Gr68a Gr68a Ir67c Ir67c Ir20a Ir20a Gr32a Gr32a Gr33a Gr33a ppk ppk Gr39a Gr39a Ir94a Ir94a ppk25 ppk25 Ir56b Ir56b Ir56d Ir56d Ir56a Ir56a Lhr Lhr Ir52c Ir52c Ir47a Ir47a Ir62a Ir62a NFAT NFAT ppk23 ppk23 Ir94h Ir94h Ir52a Ir52a Ir52d Ir52d Ir52b Ir52b ppk29 ppk29 Ir94f Ir94f Ir60b Ir60b Ir94e Ir94e Gr66a Gr66a fru fru ppk8 ppk8 dsx dsx Ir25a Ir25a Nrx-1 Nrx-1 Ir94c Ir94c
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Gr5aGustatory receptor 5a for trehalose; Gustatory receptor required for response to the sugar trehalose in taste neurons. Gr5a neurons selectively respond to sugars, in contrast to Gr66a cells which respond to bitter compounds. Flies are attracted to sugars and avoid bitter substances, suggesting that Gr5a neuron activity is sufficient to mediate acceptance behavior. Sugar signal transduction occurs through coupling with G-proteins such as Galpha49B and G-salpha60A. (444 aa)
Gr64fGustatory receptor for sugar taste 64f; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64a to detect sucrose, maltose, and glucose. (469 aa)
OdsHOds-site homeobox (OdsH) encodes a protein involved in male sterility. (382 aa)
Ir76bIonotropic receptor 76b (Ir76b) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in chemosensory detection of various amines and salt, as a probable co-receptor subunit. (636 aa)
Grasp65Grasp65 (Grasp65) encodes a myristoylated Golgi protein that binds the product of GM130 and has been shown to mediate the Golgi bypass of transmembrane proteins. (460 aa)
Gr68aGustatory receptor 68a; Dsx-dependent essential component of pheromone-driven courtship behavior. Recognizes a female pheromone involved in the second step (tapping step) of the courtship display which is essential for efficient execution of the entire courtship sequence and timely mating. Required for detection of the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) and courtship suppression is mediated by the rele [...] (389 aa)
Ir67cIonotropic receptor 67c; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (573 aa)
Ir20aIonotropic receptor 20a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (563 aa)
Gr32aGustatory and pheromone receptor 32a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions as a pheromone receptor for a male inhibitory pheromone and promotes male-male aggression and suppresses male-male courtship. Also promotes preferentially virgin females courting over mated females. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr21a subfamily. (461 aa)
Gr33aGustatory and pheromone receptor 33a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing all nonvolatile repulsive chemicals, including tastants, pheromones, and especially N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions also as a pheromone receptor for a male inhibitory pheromone leading to male-male courtship suppression. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily. (475 aa)
ppkAmiloride-sensitive Na+ channel; Pickpocket (ppk) encodes an acid-sensing sodium channel from the degenerin/epithelial sodium channel (DEG/ENaC) family. It contributes to mechanical nociception, larval behavior and dendrite morphogenesis. (606 aa)
Gr39aGustatory and pheromone receptor 39a, isoform C; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Plays a role in sustaining courtship behavior in males, possibly through the reception of a stimulating arrestant pheromone. (381 aa)
Ir94aIonotropic receptor 94a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (595 aa)
ppk25Pickpocket 25 (ppk25) encodes a DEG/ENaC channel subunit involved in male courtship behavior and pheromone detection; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (451 aa)
Ir56bIonotropic receptor 56b; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (408 aa)
Ir56dIonotropic receptor 56d; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (632 aa)
Ir56aIonotropic receptor 56a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (603 aa)
LhrLethal hybrid rescue (Lhr) encodes a protein required to repress transposable element and satellite DNA expression. It also has a gain-of-function phenotype of causing lethality in F1 male hybrids between D. melanogaster and D. simulans. (334 aa)
Ir52cIonotropic receptor 52c (Ir52c) encodes a protein involved in male mating behavior. (599 aa)
Ir47aIonotropic receptor 47a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (593 aa)
Ir62aIonotropic receptor 62a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (606 aa)
NFATNFAT nuclear factor, isoform B; DNA-binding transcription factor activity; chromatin binding; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; negative regulation of synaptic vesicle exocytosis; response to salt stress. (1457 aa)
ppk23Pickpocket 23 (ppk23) encodes a gustatory-specific putative non-voltage gated cation channel that belongs to the Degenerin/Epithelial sodium channel (DEG/ENaC) family. It contributes to pheromone perception and male courtship behavior. (591 aa)
Ir94hIonotropic receptor 94h; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (559 aa)
Ir52aIonotropic receptor 52a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (599 aa)
Ir52dIonotropic receptor 52d; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus; reproductive behavior. (594 aa)
Ir52bIonotropic receptor 52b; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (596 aa)
ppk29Pickpocket 29 (ppk29) encodes a putative non-voltage gated cation channel that belongs to the Degenerin/Epithelial sodium channel (DEG/ENaC) family. It contributes to pheromone signaling and neuronal excitability. (425 aa)
Ir94fIonotropic receptor 94f; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (558 aa)
Ir60bIonotropic receptor 60b; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (577 aa)
Ir94eIonotropic receptor 94e; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (611 aa)
Gr66aGustatory receptor for bitter taste 66a; Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N- Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoid [...] (527 aa)
fruSex determination protein fruitless; Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associ [...] (960 aa)
ppk8Pickpocket 8, isoform H; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (569 aa)
dsxProtein doublesex; Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female- specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body. (572 aa)
Ir25aIonotropic receptor 25a; Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection. Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b. Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool av [...] (947 aa)
Nrx-1Neurexin 1, isoform F; Neurexin 1 (Nrx-1) encodes a transmembrane synaptic adhesive molecule that regulates the synaptic architecture and function in the brain and neuromuscular junction. It contributes to synaptic growth, transmission, synaptic formation and also regulation of learning and memory, locomotion and visual function. (1847 aa)
Ir94cIonotropic receptor 94c; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (604 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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