STRINGSTRING
Sirt1 Sirt1 Nfs1 Nfs1 srl srl HDAC3 HDAC3 mAcon1 mAcon1 HDAC4 HDAC4 COX4 COX4 HDAC6 HDAC6 ubl ubl Debcl Debcl COX4L COX4L TFAM TFAM Keap1 Keap1 Decay Decay Lkb1 Lkb1 mAcon2 mAcon2 IscU IscU Cyt-c-p Cyt-c-p Cyt-c-d Cyt-c-d
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Sirt1NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. (823 aa)
Nfs1Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (462 aa)
srlSpargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding. (1067 aa)
HDAC3Histone deacetylase 3 (HDAC3) encodes a histone deacetylase involved in chromatin silencing. It controls cell growth through apoptosis suppression by regulating transcription of hid; Belongs to the histone deacetylase family. HD Type 1 subfamily. (438 aa)
mAcon1Aconitate hydratase, mitochondrial; Mitochondrial aconitase 1 (mAcon1) encodes an enzyme that harbors an iron-sulfur cluster and catalyses the first step of the Krebs Cycle in mitochondria, converting citrate into isocitrate; Belongs to the aconitase/IPM isomerase family. (787 aa)
HDAC4Histone deacetylase 4, isoform G; Histone deacetylase 4 (HDAC4) encodes a Class IIa histone deacetylase that modulates gene expression by associating with transcriptional factors. It is regulated by nucleocytoplasmic shuttling and contributes to embryogenesis, muscle development, circadian function, energy balance and memory. (1269 aa)
COX4Cytochrome c oxidase subunit 4 (COX4) encodes a subunit of the cytochrome-c oxidase. It is involved in cell proliferation and golgi structural organisation. (182 aa)
HDAC6Histone deacetylase 6, isoform G; Histone deacetylase 6 (HDAC6) encodes a cytosolic deacetylase that functions as a key modulator of proteostasis by mediating ubiquitin-proteasomal and lysosomal degradation of native and/or misfolded proteins. (1179 aa)
ublUbiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process. (73 aa)
DebclDeath executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. (300 aa)
COX4LCytochrome-c oxidase activity. It is involved in the biological process described with: mitochondrial electron transport, cytochrome c to oxygen. (176 aa)
TFAMMitochondrial transcription factor A (TFAM) encodes a protein essential for mtDNA transcription and replication. It also binds to mtDNA nonspecifically, and plays a role in mtDNA maintenance by packaging mtDNA. (284 aa)
Keap1Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. (776 aa)
DecayDeath executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family. (308 aa)
Lkb1Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. (567 aa)
mAcon2Aconitate hydratase, mitochondrial; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity. It is involved in the biological process described with: tricarboxylic acid cycle; multicellular organism reproduction; Belongs to the aconitase/IPM isomerase family. (783 aa)
IscUIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (154 aa)
Cyt-c-pCytochrome c-2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (108 aa)
Cyt-c-dCytochrome c-1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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