node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B52 | Doa | FBpp0300515 | FBpp0289029 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. | 0.536 |
B52 | Rbp1 | FBpp0300515 | FBpp0081754 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | RNA-binding protein 1; Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site. Belongs to the splicing factor SR family. | 0.828 |
B52 | SC35 | FBpp0300515 | FBpp0297362 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | SR family splicing factor SC35 (SC35) encodes a mRNA binding protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. | 0.804 |
B52 | SF2 | FBpp0300515 | FBpp0293269 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | Splicing factor 2 (SF2) encodes a protein involved in alternative mRNA splicing, RNA export from the nucleus and the regulation of the RNA metabolism. | 0.671 |
B52 | SLIRP1 | FBpp0300515 | FBpp0076923 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | SRA stem-loop interacting RNA binding protein 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA processing; regulation of RNA metabolic process. | 0.630 |
B52 | SRPK | FBpp0300515 | FBpp0303478 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | SR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. | 0.893 |
B52 | Srp54 | FBpp0300515 | FBpp0079471 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | LD29830p; Srp54 (Srp54) encodes a protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. | 0.700 |
B52 | Srpk79D | FBpp0300515 | FBpp0297551 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | Serine-arginine protein kinase at 79D (Srpk79D) is required to prevent the formation of axonal protein aggregates containing the active zone-protein encoded by brp. | 0.916 |
B52 | dsx | FBpp0300515 | FBpp0303107 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | Protein doublesex; Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female- specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body. | 0.426 |
B52 | tra2 | FBpp0300515 | FBpp0088946 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | Transformer-2 sex-determining protein; Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female- specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to [...] | 0.842 |
B52 | x16 | FBpp0300515 | FBpp0078996 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | X16 splicing factor (x16) encodes a protein involved in RNA splicing and RNA metabolism regulation. | 0.633 |
Cdk1 | betaTub56D | FBpp0079641 | FBpp0085721 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. | 0.633 |
Doa | B52 | FBpp0289029 | FBpp0300515 | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. | 0.536 |
Doa | Fst | FBpp0289029 | FBpp0081579 | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. | LP07623p; Frost (Fst) encodes a potentially secreted protein that protects female reproduction after cold treatment. | 0.669 |
Doa | Rbp1 | FBpp0289029 | FBpp0081754 | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. | RNA-binding protein 1; Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site. Belongs to the splicing factor SR family. | 0.702 |
Doa | SC35 | FBpp0289029 | FBpp0297362 | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. | SR family splicing factor SC35 (SC35) encodes a mRNA binding protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. | 0.597 |
Doa | SF2 | FBpp0289029 | FBpp0293269 | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. | Splicing factor 2 (SF2) encodes a protein involved in alternative mRNA splicing, RNA export from the nucleus and the regulation of the RNA metabolism. | 0.604 |
Doa | SRPK | FBpp0289029 | FBpp0303478 | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. | SR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. | 0.657 |
Doa | Srp54 | FBpp0289029 | FBpp0079471 | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. | LD29830p; Srp54 (Srp54) encodes a protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. | 0.903 |
Doa | Srpk79D | FBpp0289029 | FBpp0297551 | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. | Serine-arginine protein kinase at 79D (Srpk79D) is required to prevent the formation of axonal protein aggregates containing the active zone-protein encoded by brp. | 0.639 |