(22 nodes) (2015) Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster. network (Drosophila melanogaster)

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second shell of interactors

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	Cyp4d21	Probable cytochrome P450 4d21; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (511 aa)
	Gr33a	Gustatory and pheromone receptor 33a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing all nonvolatile repulsive chemicals, including tastants, pheromones, and especially N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions also as a pheromone receptor for a male inhibitory pheromone leading to male-male courtship suppression. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily. (475 aa)
	Cyp28a5	Probable cytochrome P450 28a5; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (505 aa)
	GstD8	Glutathione S transferase D8 (GstD8) encodes an enzyme with broad substrate specificity involved in glutathione metabolism. (212 aa)
	Cyp313a1	Probable cytochrome P450 313a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (492 aa)
	Keap1	Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. (776 aa)
	Cyp12a5	Probable cytochrome P450 12a5, mitochondrial; Heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family. (536 aa)
	Gr93a	Gustatory receptor for bitter taste 93a; Gustatory receptor required for response to the bitter in taste neurons. Gr93a cells respond to bitter compounds such as caffeine. Flies avoid bitter substances, suggesting that Gr93a neuron activity is sufficient to mediate avoidance behavior. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr93a subfamily. (419 aa)
	Cyp6a20	Probable cytochrome P450 6a20; Cyp6a20 (Cyp6a20) encodes a protein that may function to degrade aggression-promoting pheromones based on indirect observations such as its expression pattern and the increased aggressive behavior shown in Cyp6a20 mutants. (501 aa)
	RpL32	60S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
	betaTub56D	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (456 aa)
	Cyp6a8	Cytochrome P450 6a8; Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (506 aa)
	Cyp4p1	Cytochrome P450 4p1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (513 aa)
	Cyp6d5	Probable cytochrome P450 6d5; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (508 aa)
	Cyp12d1-d	Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). (521 aa)
	GstD1	Glutathione S-transferase D1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification. (209 aa)
	Act5C	Actin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
	Cyp12d1-p	Probable cytochrome P450 12d1 proximal, mitochondrial; Cyp12d1-p (Cyp12d1-p) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). (521 aa)
	Cyp6w1	Probable cytochrome P450 6w1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (514 aa)
	Cyp6a18	Probable cytochrome P450 6a18; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (507 aa)
	GstE12	Glutathione S transferase E12 (GstE12) encodes an enzyme involved in glutathione metabolism; Belongs to the GST superfamily. (223 aa)
	Gr66a	Gustatory receptor for bitter taste 66a; Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N- Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoid [...] (527 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Act5C	GstD1	FBpp0311818	FBpp0099824	Actin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Glutathione S-transferase D1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification.	0.524
Act5C	GstD8	FBpp0311818	FBpp0082047	Actin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Glutathione S transferase D8 (GstD8) encodes an enzyme with broad substrate specificity involved in glutathione metabolism.	0.456
Act5C	GstE12	FBpp0311818	FBpp0293853	Actin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Glutathione S transferase E12 (GstE12) encodes an enzyme involved in glutathione metabolism; Belongs to the GST superfamily.	0.471
Act5C	RpL32	FBpp0311818	FBpp0084959	Actin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	60S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation.	0.855
Act5C	betaTub56D	FBpp0311818	FBpp0085721	Actin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.703
Cyp12a5	Cyp28a5	FBpp0083144	FBpp0080164	Probable cytochrome P450 12a5, mitochondrial; Heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.	Probable cytochrome P450 28a5; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.	0.466
Cyp12a5	Cyp313a1	FBpp0083144	FBpp0082413	Probable cytochrome P450 12a5, mitochondrial; Heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.	Probable cytochrome P450 313a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.	0.446
Cyp12a5	Cyp4p1	FBpp0083144	FBpp0087673	Probable cytochrome P450 12a5, mitochondrial; Heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.	Cytochrome P450 4p1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.	0.514
Cyp12a5	Cyp6a18	FBpp0083144	FBpp0308423	Probable cytochrome P450 12a5, mitochondrial; Heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.	Probable cytochrome P450 6a18; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.	0.404
Cyp12a5	Cyp6a20	FBpp0083144	FBpp0289404	Probable cytochrome P450 12a5, mitochondrial; Heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.	Probable cytochrome P450 6a20; Cyp6a20 (Cyp6a20) encodes a protein that may function to degrade aggression-promoting pheromones based on indirect observations such as its expression pattern and the increased aggressive behavior shown in Cyp6a20 mutants.	0.439
Cyp12a5	Cyp6d5	FBpp0083144	FBpp0088707	Probable cytochrome P450 12a5, mitochondrial; Heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.	Probable cytochrome P450 6d5; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.	0.482
Cyp12a5	Cyp6w1	FBpp0083144	FBpp0311596	Probable cytochrome P450 12a5, mitochondrial; Heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.	Probable cytochrome P450 6w1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.	0.523
Cyp12d1-d	Cyp12d1-p	FBpp0088436	FBpp0311725	Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).	Probable cytochrome P450 12d1 proximal, mitochondrial; Cyp12d1-p (Cyp12d1-p) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).	0.509
Cyp12d1-d	Cyp313a1	FBpp0088436	FBpp0082413	Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).	Probable cytochrome P450 313a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.	0.410
Cyp12d1-d	Cyp4p1	FBpp0088436	FBpp0087673	Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).	Cytochrome P450 4p1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.	0.448
Cyp12d1-d	Cyp6a8	FBpp0088436	FBpp0086585	Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).	Cytochrome P450 6a8; Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.	0.525
Cyp12d1-d	Cyp6d5	FBpp0088436	FBpp0088707	Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).	Probable cytochrome P450 6d5; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.	0.520
Cyp12d1-d	Cyp6w1	FBpp0088436	FBpp0311596	Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).	Probable cytochrome P450 6w1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.	0.512
Cyp12d1-d	Keap1	FBpp0088436	FBpp0082864	Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).	Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress.	0.438
Cyp12d1-p	Cyp12d1-d	FBpp0311725	FBpp0088436	Probable cytochrome P450 12d1 proximal, mitochondrial; Cyp12d1-p (Cyp12d1-p) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).	Probable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT).	0.509