STRINGSTRING
Ugt302E1 Ugt302E1 mAcon1 mAcon1 Ugt302K1 Ugt302K1 Ugt303A1 Ugt303A1 Ugt49B2 Ugt49B2 Pdk1 Pdk1 Ugt36D1 Ugt36D1 Ugt35E1 Ugt35E1 Ugt36F1 Ugt36F1 Pten Pten Ugt35C1 Ugt35C1 Ugt49C1 Ugt49C1 Gapdh1 Gapdh1 CG9010 CG9010 betaTub56D betaTub56D Ugt50B3 Ugt50B3 Ugt35D1 Ugt35D1 Irp-1A Irp-1A Akt1 Akt1 CG4546 CG4546 CG14740 CG14740 Ugt35B1 Ugt35B1 kdn kdn Ugt49B1 Ugt49B1 LysS LysS Gapdh2 Gapdh2 CG7430 CG7430 ATPsynbetaL ATPsynbetaL CG5144 CG5144 Argk Argk Ugt301D1 Ugt301D1 Ugt36E1 Ugt36E1 MAGE MAGE Irp-1B Irp-1B mAcon2 mAcon2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ugt302E1UDP-glucuronosyltransferase; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups; Belongs to the UDP-glycosyltransferase family. (521 aa)
mAcon1Aconitate hydratase, mitochondrial; Mitochondrial aconitase 1 (mAcon1) encodes an enzyme that harbors an iron-sulfur cluster and catalyses the first step of the Krebs Cycle in mitochondria, converting citrate into isocitrate; Belongs to the aconitase/IPM isomerase family. (787 aa)
Ugt302K1UDP-glucuronosyltransferase; UDP-glycosyltransferase family 302 member K1 (Ugt302K1) encodes a UDP-glucosyltransferase; Belongs to the UDP-glycosyltransferase family. (519 aa)
Ugt303A1UDP-glucuronosyltransferase; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups; Belongs to the UDP-glycosyltransferase family. (526 aa)
Ugt49B2UDP-glucuronosyltransferase; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups; Belongs to the UDP-glycosyltransferase family. (526 aa)
Pdk13-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (836 aa)
Ugt36D1UDP-glucuronosyltransferase; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity; Belongs to the UDP-glycosyltransferase family. (519 aa)
Ugt35E1UDP-glucuronosyltransferase; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity; Belongs to the UDP-glycosyltransferase family. (527 aa)
Ugt36F1UDP-glucuronosyltransferase; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups. It is involved in the biological process described with: UDP-glucose metabolic process; xenobiotic metabolic process; Belongs to the UDP-glycosyltransferase family. (525 aa)
PtenPhosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. (514 aa)
Ugt35C1UDP-glucuronosyltransferase; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups; Belongs to the UDP-glycosyltransferase family. (517 aa)
Ugt49C1UDP-glucuronosyltransferase; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups; Belongs to the UDP-glycosyltransferase family. (530 aa)
Gapdh1Glyceraldehyde 3 phosphate dehydrogenase 1 (Gapdh1) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glycolysis, myoblast fusion and the development of somatic muscle. (332 aa)
CG9010Glyceraldehyde-3-phosphate dehydrogenase; Peptidyl-cysteine S-nitrosylase activity; NADP binding; NAD binding; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. It is involved in the biological process described with: oxidation-reduction process; glycolytic process; glucose metabolic process. (343 aa)
betaTub56DTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (456 aa)
Ugt50B3UDP-glucuronosyltransferase; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups; Belongs to the UDP-glycosyltransferase family. (524 aa)
Ugt35D1UDP-glucuronosyltransferase; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity; Belongs to the UDP-glycosyltransferase family. (521 aa)
Irp-1AIron regulatory protein 1A (Irp-1A) encodes a cytosolic aconitase that under iron deficiency (or if cytosolic superoxide is present) loses its iron-sulfur cluster, changes confirmation and binds iron regulatory elements (so far identified on the products of SdhB and Fer1HCH mRNAs); Belongs to the aconitase/IPM isomerase family. (902 aa)
Akt1RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] (611 aa)
CG4546GH24918p; Kinase activity; creatine kinase activity. It is involved in the biological process described with: multicellular organism reproduction; phosphocreatine biosynthetic process; Belongs to the ATP:guanido phosphotransferase family. (457 aa)
CG14740Citrate (Si)-synthase activity. It is involved in the biological process described with: carbohydrate metabolic process; tricarboxylic acid cycle. (478 aa)
Ugt35B1UDP-glucuronosyltransferase; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups. It is involved in the biological process described with: UDP-glucose metabolic process; Belongs to the UDP-glycosyltransferase family. (516 aa)
kdnProbable citrate synthase, mitochondrial; Plays a role in controlling neuronal activity and seizure susceptibility; Belongs to the citrate synthase family. (522 aa)
Ugt49B1UDP-glucuronosyltransferase; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity. It is involved in the biological process described with: UDP-glucose metabolic process; Belongs to the UDP-glycosyltransferase family. (532 aa)
LysSLysozyme S; Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food; Belongs to the glycosyl hydrolase 22 family. (140 aa)
Gapdh2Glyceraldehyde 3 phosphate dehydrogenase 2 (Gapdh2) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glucose homeostasis; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
CG7430Flavin adenine dinucleotide binding; dihydrolipoyl dehydrogenase activity; electron transfer activity. It is involved in the biological process described with: tricarboxylic acid cycle; lipoamide metabolic process; oxidation-reduction process; glycine catabolic process; cell redox homeostasis. (504 aa)
ATPsynbetaLATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (622 aa)
CG5144Uncharacterized protein; Kinase activity; creatine kinase activity. It is involved in the biological process described with: phosphocreatine biosynthetic process; Belongs to the ATP:guanido phosphotransferase family. (388 aa)
ArgkKinase activity; arginine kinase activity; creatine kinase activity. It is involved in the biological process described with: phosphocreatine biosynthetic process; phosphorylation; Belongs to the ATP:guanido phosphotransferase family. (562 aa)
Ugt301D1UDP-glucuronosyltransferase; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity; Belongs to the UDP-glycosyltransferase family. (530 aa)
Ugt36E1UDP-glucuronosyltransferase; UDP-glycosyltransferase activity; transferase activity, transferring hexosyl groups. It is involved in the biological process described with: UDP-glucose metabolic process; xenobiotic metabolic process; Belongs to the UDP-glycosyltransferase family. (517 aa)
MAGERE25453p; MAGE (MAGE) encodes a component of the SMC5/6 protein complex. This complex is critical to genome stability, and is required for homologous DNA recombination-based processes. (232 aa)
Irp-1BIron regulatory protein 1B (Irp-1B) encodes a cytosolic aconitase highly homologous to the product of Irp-1A; Belongs to the aconitase/IPM isomerase family. (899 aa)
mAcon2Aconitate hydratase, mitochondrial; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity. It is involved in the biological process described with: tricarboxylic acid cycle; multicellular organism reproduction; Belongs to the aconitase/IPM isomerase family. (783 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (32%) [HD]