STRINGSTRING
Alg14 Alg14 rt rt MAN1 MAN1 PIG-A PIG-A tw tw Alg11 Alg11 anchor anchor Dpm2 Dpm2 Dpm3 Dpm3 Alg13 Alg13 Alg1 Alg1 Dpm1 Dpm1 PGAP1 PGAP1 PIG-T PIG-T shg shg PIG-M PIG-M
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Alg14ALG14, UDP-N-acetylglucosaminyltransferase subunit; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: dolichol-linked oligosaccharide biosynthetic process. (191 aa)
rtProtein O-mannosyltransferase 1; Rotated abdomen (rt) encodes a protein that transfers a mannose to the Ser/Thr residues of the product of Dg, via forming an heterodimer with the product of tw. Its roles include myogenesis, muscle architecture and cell adhesion. (886 aa)
MAN1Inner nuclear membrane protein Man1; Inner nuclear membrane protein. Acts as a negative regulator of the BMP (Dpp) signaling cascade during crossvein development in pupal wings and possibly during synaptic transmission at the neuromuscular junction (NMJ). Appears to be required for pupal development and consequently transition to the adult stage. During pupal development, plays essential and redundant functions with the other LEM domain proteins; bocks and Ote. (650 aa)
PIG-APhosphatidylinositol glycan anchor biosynthesis class A, isoform A; Phosphatidylinositol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (479 aa)
twProtein O-mannosyl-transferase 2; Twisted (tw) encodes a protein that transfers a mannose to the Ser/Thr residues of dystroglycan, via forming an heterodimer with the product of rt. Its roles include myogenesis, muscle architecture and cell adhesion. (765 aa)
Alg11ALG11, alpha-1,2-mannosyltransferase, isoform A; GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. It is involved in the biological process described with: protein N-linked glycosylation; oligosaccharide-lipid intermediate biosynthetic process. (475 aa)
anchorAnchor, isoform B; It is involved in the biological process described with: transmembrane transport; intracellular signal transduction. (957 aa)
Dpm2Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (81 aa)
Dpm3Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (94 aa)
Alg13Glyco_tran_28_C domain-containing protein; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: dolichol-linked oligosaccharide biosynthetic process. (171 aa)
Alg1ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase activity. It is involved in the biological process described with: protein glycosylation. (446 aa)
Dpm1Probable dolichol-phosphate mannosyltransferase; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; Belongs to the glycosyltransferase 2 family. (241 aa)
PGAP1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. Belongs to the GPI inositol-deacylase family. (980 aa)
PIG-TPhosphatidylinositol glycan anchor biosynthesis class T; GPI-anchor transamidase activity. It is involved in the biological process described with: attachment of GPI anchor to protein. (633 aa)
shgDE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...] (1507 aa)
PIG-MGPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. (466 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.