STRINGSTRING
Clp Clp Wdr33 Wdr33 Sym Sym CstF64 CstF64 Cpsf100 Cpsf100 Slbp Slbp CstF50 CstF50 His2A:CG31618 His2A:CG31618 Lsm11 Lsm11 Myc Myc
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ClpCleavage and polyadenylation specificity factor subunit 4; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity. Binds RNA polymers with a preference for G- and/or C-rich clusters. Binds single-stranded DNA non-specifically. (296 aa)
Wdr33WD repeat domain 33, isoform A; It is involved in the biological process described with: mRNA polyadenylation. (807 aa)
SymSymplekin (Sym) encodes a large protein that contains many protein interaction sites, and acts as a scaffold for protein complexes in the nucleus. It functions in RNA 3' end formation for both polyadenyated mRNAs and non-polyadenylated histone mRNAs. In some cells it also localizes to the cell cortex, especially the tricellular junctions of some epithelia. (1165 aa)
CstF64Cleavage stimulation factor 64 kD subunit (CstF64) encodes an RNA-binding protein that is part of the cleavage stimulation factor (CstF) complex. As part of the CstF complex, it interacts with the polyadenylation protein encoded bysu(f). The product of CstF64 is necessary for the cleavage and polyadenylation of most mRNAs and for 3' end processing of mRNAs that encode the replication-dependent histones. (419 aa)
Cpsf100Probable cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'- ends of polyadenylated and histone pre-mRNA. (756 aa)
SlbpHistone RNA hairpin-binding protein; Stem-loop binding protein (Slbp) encodes a protein that plays an essential role in 3' end processing of histone pre-mRNAs into mature histone mRNAs by recruiting the product of snRNA:U7 to the pre-mRNA. (276 aa)
CstF50Cleavage stimulation factor 50 kD subunit. (424 aa)
His2A:CG31618Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
Lsm11FI05704p; Lsm11 (Lsm11) encodes one of the seven proteins that form a heptameric Sm ring in the U7 snRNP, which is a key factor involved in 3' end processing of histone pre-mRNAs. It interacts with the product of FLASH. The two interacting proteins form a biochemical platform that recruits a number of polyadenylation subunits to the U7 snRNP, including the products of Sym, Cpsf100, Cpsf73 and CstF64. (256 aa)
MycMyc protein; Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiqui [...] (717 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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