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| | AttC | Immune-induced peptide 16; Attacin-C (AttC) encodes an immune inducible peptide that shows homology to antibacterial peptides having activity against Gram-negative bacteria; Belongs to the attacin/sarcotoxin-2 family. (241 aa) |
| | Egfr | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] (1426 aa) |
| | Or59a | Odorant receptor 59a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to ethyl acetate, anisole, hexanoic acid, and pyrazines. (379 aa) |
| | CG2736 | GH15894p; Belongs to the CD36 family. (507 aa) |
| | LysX | Lysozyme X; Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. May be involved in the clearance of bacteria from the larval gut before metamorphosis; Belongs to the glycosyl hydrolase 22 family. (142 aa) |
| | CG8960 | GEO04221p1. (114 aa) |
| | Drsl2 | Drosomycin-like 2 (Drsl2) encodes a secreted peptide with homology to the antifungal peptide encoded by Drs. (70 aa) |
| | CG14983 | GEO11537p1; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: interstrand cross-link repair; protein ubiquitination. (163 aa) |
| | CG13711 | Uncharacterized protein; It is involved in the biological process described with: regulation of localization. (127 aa) |
| | hop | Tyrosine-protein kinase hopscotch; Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair- rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. (1177 aa) |
| | PGRP-SA | Peptidoglycan-recognition protein SA; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE. Has no activity against Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition. May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) an [...] (203 aa) |
| | dome | Cytokine receptor; Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis. (1282 aa) |
| | edin | Elevated during infection (edin) encodes a short secreted peptide involved in humoral immune response. Its expression is strongly induced upon bacterial, viral and wasp stimulation as well as in other stress situations. It is required in the fat body for a normal encapsulation against parasitoid wasps by the larval hemocytes. (115 aa) |
| | PGRP-SB1 | Peptidoglycan recognition protein SB1 (PGRP-SB1) encodes a secreted peptidoglycan recognition protein (PGRP) with an amidase activity against DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It is strongly induced upon bacterial infection by the immune deficiency pathway, suggesting a role as an immune effector; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (190 aa) |
| | Tom | Twin of m4 (Tom) is a member of the Bearded gene family that encodes a regulator of the Notch signaling pathway. (158 aa) |
| | BobA | Brother of bearded A; Ubiquitin protein ligase binding. It is involved in the biological process described with: defense response to bacterium; cell fate specification; sensory organ precursor cell fate determination; negative regulation of Notch signaling pathway. (78 aa) |
| | Fbp1 | Fat-body protein 1. (1029 aa) |
| | btl | Fibroblast growth factor receptor homolog 2; May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues. (1052 aa) |
| | Cpr67Fb | Cuticular protein 67Fb; Structural constituent of cuticle; structural constituent of chitin-based larval cuticle. It is involved in the biological process described with: multicellular organism reproduction; chitin-based cuticle development. (122 aa) |
| | CG18179 | RE53819p; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. (268 aa) |
| | PGRP-LA | Peptidoglycan-recognition protein LA; Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response. (368 aa) |
| | PGRP-LF | Peptidoglycan recognition protein LF (PGRP-LF) encodes a transmembrane receptor that prevents the spontaneous activation of the immune deficiency pathway receptor encoded by PGRP-LC. (369 aa) |
| | GNBP3 | Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway. (490 aa) |
| | Cp19 | Chorion protein S19; Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment; Belongs to the chorion protein S19 family. (173 aa) |
| | PGRP-SD | Peptidoglycan-recognition protein SD; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway. Has no activity against on Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SA in Gram-positive bacteria recognition. May act by activating the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Recognizes S.aureus PGN; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (186 aa) |
| | Acp65Aa | Adult cuticle protein 65Aa (Acp65Aa) encodes an adult-specific cuticle protein. Acp65Aa binds chitin and is only found in regions of flexible cuticle such as the abdominal intersegmental membranes, wing hinges and leg joints. (105 aa) |
| | Jon65Aii | Jonah 65Aii; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. (259 aa) |
| | Lcp65Ag1 | Lcp65Ag1 (Lcp65Ag1) encodes a small structural protein of the chitin based larval cuticle. (105 aa) |
| | Lcp65Ag3 | Larval cuticle protein; Structural constituent of cuticle; structural constituent of chitin-based larval cuticle. It is involved in the biological process described with: chitin-based cuticle development. (105 aa) |
| | Npc1b | NPC intracellular cholesterol transporter 1 homolog 1b; Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking. Belongs to the patched family. (1254 aa) |
| | Traf4 | TNF-receptor-associated factor 4 (Traf4) encodes an adapter protein thought to bind the TNF receptor and activate downstream signaling. However, it also has TNF independent roles, especially with respect to morphogenesis. The product of Traf4 interacts with and localizes polarity and adherens junction proteins such as the products of baz and arm respectively. It is required for normal embryonic development, cell death, and cell growth. (486 aa) |
| | Toll-9 | Toll-9, isoform A; Toll-9 (Toll-9) encodes a transmembrane signalling receptor belonging to the Toll family of protein. (900 aa) |
| | Cpr78E | Cuticular protein 78E; Structural constituent of chitin-based larval cuticle; structural constituent of cuticle. It is involved in the biological process described with: chitin-based cuticle development. (137 aa) |
| | Acp1 | Adult cuticle protein 1; Component of the cuticle of the adult fruit fly. Could be involved in thickening of the hard adult cuticle. (135 aa) |
| | Tep2 | Thioester-containing protein 2 (Tep2) is a member of the Thioester-containing proteins (TEP) family of genes. The product of Tep2 has endopeptidase inhibitor activity and participates in the cellular immune response to certain Gram-negative bacteria. (1420 aa) |
| | LManVI | Alpha-mannosidase activity; carbohydrate binding. It is involved in the biological process described with: protein deglycosylation; mannose metabolic process. (1007 aa) |
| | Toll-4 | Toll-4 (Toll-4) encodes a putative transmembrane protein related to Toll by virtue of containing intracellular TIR domain and extracellular Leucine-rich repeats. It is expressed in the apical part of the embryonic lymph gland precursors. (1125 aa) |
| | Cyp4e3 | Cytochrome P450-4e3 (Cyp4e3) encodes an endoplasmic reticulum protein that plays a role in insecticide tolerance. Upon insecticide feeding Cyp4e3 is significantly up-regulated. Cyp4e3 knockdown in the Malpighian tubule principal cells reduces survival of insecticide-fed flies. Cyp4e3 protein may also regulate hydrogen peroxide levels in the endoplasmic reticulum and its absence triggers JAK/STAT and NF-kappaB-mediated stress responses. (526 aa) |
| | vir-1 | Virus-induced RNA 1 (vir-1) is produced from a promoter that is induced by viral infection. It can be used as a marker of the induction of an antiviral response. Its expression is regulated by the Jak/STAT pathway. (431 aa) |
| | CG11865 | Metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis. (240 aa) |
| | Tep1 | Thioester-containing protein 1; Endopeptidase inhibitor activity. It is involved in the biological process described with: innate immune response. (1354 aa) |
| | Gr36c | Putative gustatory receptor 36c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (390 aa) |
| | MstProx | MstProx (MstProx) encodes a protein with an intracellular Toll/interleukin-1 receptor domain and extracellular Leucine-rich repeats. Although also designated as "Toll-3" and related to Tl, it is not known to activate the canonical Toll signaling pathway or antimicrobial response. (965 aa) |
| | CG14605 | Uncharacterized protein, isoform B; Carbohydrate:proton symporter activity. It is involved in the biological process described with: glucose import. (432 aa) |
| | Npc2d | Niemann-Pick type C-2d; Sterol binding. It is involved in the biological process described with: sterol transport; intracellular cholesterol transport. (173 aa) |
| | GstD2 | Glutathione S-transferase D2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May be involved in detoxification. (215 aa) |
| | CG4830 | RE54693p; CoA-ligase activity; fatty acid ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (534 aa) |
| | yellow-f | L-dopachrome tautomerase yellow-f; Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. May play a role in melanization reactions during larval and early pupal stages. Belongs to the major royal jelly protein family. (429 aa) |
| | Lip3 | Lipase 3; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. (394 aa) |
| | Spn88Eb | CG6687 protein; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: response to fungus; negative regulation of endopeptidase activity; epithelium regeneration; regulation of stem cell division; negative regulation of proteolysis; Belongs to the serpin family. (426 aa) |
| | AttD | Attacin-D (AttD) encodes is an immune inducible peptide that shows homology to antibacterial peptides having activity against Gram-negative bacteria. (181 aa) |
| | CG17819 | LP07781p; GTP binding. It is involved in the biological process described with: intracellular protein transport; vesicle-mediated transport; Belongs to the small GTPase superfamily. Arf family. (186 aa) |
| | Gr94a | Putative gustatory receptor 94a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (404 aa) |
| | Lsd-1 | Lipid storage droplet-1 (Lsd-1) encodes a protein associated with lipid droplets. It protects lipid droplets from lipase mediated remobilization and facilitates lipolysis by serving as an anchoring point for lipases such as the one encoded by Hsl. It is involved in lipid storage amount regulation and energy homeostasis in concert with the product of Lsd-2. (431 aa) |
| | p38c | Putative mitogen-activated protein kinase 14C; P38c MAP kinase (p38c) encodes a protein involved in the stress and wound responses, regulating the expression of Duox and Ddc. (356 aa) |
| | Hsp68 | Heat shock protein 68 (Hsp68) encodes a protein involved in lifespan determination and response to heat shock and starvation. (635 aa) |
| | tobi | Target of brain insulin; Hydrolase activity, hydrolyzing O-glycosyl compounds. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 31 family. (657 aa) |
| | TwdlM | RE40518p; Structural constituent of chitin-based cuticle. It is involved in the biological process described with: body morphogenesis; chitin-based cuticle development. (288 aa) |
| | grass | Gram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz; Belongs to the peptidase S1 family. CLIP subfamily. (377 aa) |
| | Jon99Ci | Serine protease 3; Its major function may be to aid in digestion. (272 aa) |
| | RpL32 | 60S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa) |
| | CecA1 | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. (63 aa) |
| | CecC | Cecropin-C; Cecropin C (CecC) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is strongly expressed at the pupal stage. (63 aa) |
| | CG9733 | CLIP domain-containing serine protease; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. CLIP subfamily. (418 aa) |
| | CecB | Cecropin-B; Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage; Belongs to the cecropin family. (63 aa) |
| | Ugt35D1 | UDP-glucuronosyltransferase; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity; Belongs to the UDP-glycosyltransferase family. (521 aa) |
| | CG13427 | Uncharacterized protein; It is involved in the biological process described with: gastrulation. (105 aa) |
| | 18w | 18 wheeler (18w) encodes a member of the Toll-like receptor family. It contributes to multiple processes including ovarian follicle cell migration, antibacterial humoral response and ventral cord development. A role in convergent extension during early embryogenesis is suggested by the genetic interaction of 18w with Toll-6 and Tollo. (1385 aa) |
| | Toll-7 | Toll-like receptor 7; Toll-related receptor which binds to the neurotrophins NT1 and spz5. Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection. This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways. Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe. Function in the Va1d ORNs is necessary and sufficient for correct targeting [...] (1446 aa) |
| | DptB | Diptericin B (DptB) encodes an immune inducible antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency pathway. (120 aa) |
| | Sply | Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily. (545 aa) |
| | Mtk | Metchnikowin (Mtk) encodes an antifungal peptide that is secreted from the fat body during the systemic immune response, and is produced by various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency and/or Toll pathways. (52 aa) |
| | AttA | Attacin-A (AttA) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body and various epithelia under the regulation of the immune deficiency and, to a lesser extent, Toll pathways; Belongs to the attacin/sarcotoxin-2 family. (221 aa) |
| | Listericin | GEO12728p1; Listericin (Listericin) encodes an antibacterial protein whose induction is cooperatively regulated by the product of PGRP-LE and the JAK-STAT pathway. (121 aa) |
| | lectin-46Ca | lectin-46Ca (lectin-46Ca) encodes a protein with homology to C-type lectins. It is produced in the male accessory gland and transferred to females during mating. In mated females, it binds to sperm in the seminal receptacle. It is required for the binding of the product of SP to sperm, and for maintenance of long-term post-mating responses. (328 aa) |
| | PGRP-SC1a | Peptidoglycan-recognition protein SC1a; N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (185 aa) |
| | PGRP-SC2 | Peptidoglycan recognition protein SC2 (PGRP-SC2) encodes a secreted peptidoglycan recognition protein (PGRP) with an amidase activity against peptidoglycans. It contributes to the down-regulation of the immune deficiency pathway, notably in the fat body during systemic bacterial infection. (184 aa) |
| | Odc1 | Ornithine decarboxylase 1; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. (394 aa) |
| | Odc2 | Ornithine decarboxylase 2; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. (393 aa) |
| | PGRP-LC | Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...] (520 aa) |
| | CG33459 | Peptidase S1 domain-containing protein; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. (284 aa) |
| | Pxn | Peroxidasin; Plays a role in extracellular matrix consolidation, phagocytosis and defense. (1527 aa) |
| | Or69a | Putative odorant receptor 69a, isoform A; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity); Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily. (393 aa) |
| | CG34040 | DUF753 domain-containing protein. (281 aa) |
| | lectin-37Da | C-type lectin 37Da; Galactose-specific lectin that displays calcium-dependent activity. Binds to the surface of hemocytes and enhances hemocyte encapsulation and melanization. This is likely by interacting with carbohydrates on the surface of the hemocytes. Also displays agglutination activity against the Gram-negative bacterium E.coli. (186 aa) |
| | Hsp22 | Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. (174 aa) |
| | Prx5 | Peroxiredoxin 5 (Prx5) encodes an atypical member of the family of thiol-specific peroxidases that forms intramolecular disulfide bonds during the catalytic cycle. Its roles include antioxidant function, maintenance of cellular redox state, modulation of the immune-related signaling and protection against apoptosis. (190 aa) |
| | Acp54A1 | Accessory gland protein 54A1; It is involved in the biological process described with: multicellular organism reproduction. (46 aa) |
| | Mthfs | 5-formyltetrahydrofolate cyclo-ligase activity. It is involved in the biological process described with: tetrahydrofolate interconversion; folic acid-containing compound biosynthetic process. (201 aa) |
| | CG30288 | RT07670p; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. (282 aa) |
| | upd3 | Unpaired 3 (upd3) encodes a "cytokine" (secreted protein) of the Unpaired family that can bind and activate the JAK-STAT receptor encoded by dome. It is induced in hemocytes or in the intestine upon damage to regulate the repair response in these tissues through JAK-STAT activation. (401 aa) |
| | PGRP-LD | Peptidoglycan-recognition protein LD; Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (327 aa) |
| | AttB | Attacin-B (AttB) encodes an immune inducible peptide that shows homology to antibacterial peptides having activity against Gram-negative bacteria; Belongs to the attacin/sarcotoxin-2 family. (218 aa) |
| | bsk | Stress-activated protein kinase JNK; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade. Exhibits cytoprotective activity in neuronal c [...] (372 aa) |
| | MAPk-Ak2 | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (359 aa) |
| | CG13071 | Uncharacterized protein. (69 aa) |
| | CG43184 | Uncharacterized protein. (81 aa) |
| | PGRP-LB | Peptidoglycan recognition protein LB (PGRP-LB) encodes a secreted protein with an amidase activity that scavenges DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It negatively regulates the immune deficiency pathway; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (255 aa) |
| | PGRP-LE | Peptidoglycan-recognition protein LE; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram- negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is req [...] (345 aa) |
| | CG5665 | Uncharacterized protein, isoform C; Lipase activity; carboxylic ester hydrolase activity. It is involved in the biological process described with: lipid catabolic process. (395 aa) |
| | Dro | Drosocin (Dro) encodes an o-Glycosylated antibacterial peptide with activity against Gram-negative and Gram-positive bacteria. It is expressed in the fat body during the systemic immune response and is expressed in various epithelia. The expression of Dro is regulated at the transcriptional level mostly by the immune deficiency pathway; Belongs to the drosocin family. (64 aa) |
| | Hsp23 | Heat shock protein 23 (Hsp23) encodes a protein involved in protein folding. It contributes to the response to cold, heat and hypoxia. (186 aa) |
| | CG6933 | RE22940p; Chitin binding. It is involved in the biological process described with: chitin metabolic process. (363 aa) |
| | Sox21a | Sox21a, isoform B; Sox21a (Sox21a) encodes a Sox family transcription factor involved in the differentiation of stem cells in the midgut. (407 aa) |
| | Tep4 | Thioester-containing protein 4 (Tep4) is a member of the Thioester-containing proteins (TEP) family of genes. The product of Tep4 has endopeptidase inhibitor activity and participates in the cellular immune response to certain Gram-negative bacteria. (1498 aa) |
| | Myc | Myc protein; Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiqui [...] (717 aa) |
| | CG42367 | Uncharacterized protein; Structural constituent of cuticle. (103 aa) |
| | Eig71Ei | Eig71Ei, isoform A; It is involved in the biological process described with: metamorphosis; defense response to bacterium. (102 aa) |
| | spirit | Serine protease immune response integrator, isoform A; Serine-type endopeptidase activity; Belongs to the peptidase S1 family. (393 aa) |
| | CG7017 | RE24410p; Chitin binding. It is involved in the biological process described with: chitin metabolic process. (359 aa) |
| | PGRP-SB2 | Peptidoglycan recognition protein SB2 (PGRP-SB2) encodes a secreted peptidoglycan recognition protein (PGRP) with amidase activity against DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It is strongly induced upon bacterial infection by the immune deficiency pathway, suggesting a role as an immune effector. (191 aa) |
| | Sp7 | Serine protease 7; Serine protease which, by cleaving and activating prophenoloxidase (PPO1) after immune challenge, plays an essential role in the melanization immune response to septic wounding. May function in diverse Hayan-dependent PPO1- activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea. Important for the innate immune response to fungi. Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway. (391 aa) |
| | CG16704 | GEO11944p1; Serine-type endopeptidase inhibitor activity. (79 aa) |
| | Fas2 | Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles. (885 aa) |
| | CG17571 | Uncharacterized protein, isoform A; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. (258 aa) |
| | imd | Protein immune deficiency; Essential for the imd/NF-kappa-B (Imd) humoral and epithelial immune response to Gram-negative bacteria. Functions as an adapter protein that transduces immunity signals from the activation of pathogen recognition receptors (PRRs) by bacterial infection to the Imd signaling pathway. Binding of diaminopimelic acid-type (DAP-type) bacterial peptidoglycans (PGN) causes multimerization or clustering of PGRP receptors which activate the Imd cascade probably by recruiting imd, Fadd and Dredd to the receptor complex. Once in proximity, Dredd cleaves imd in a Fadd-de [...] (273 aa) |
| | CG12998 | RH61745p. (113 aa) |
| | Tehao | Tehao, isoform A; Tehao (Tehao) encodes a homologue of the receptor encoded by Tl. It is involved in the Toll signaling pathway and innate immune response. (795 aa) |
| | Atg8b | Autophagy-related 8b, isoform A; Microtubule binding; protein tag; ubiquitin protein ligase binding; GABA receptor binding. It is involved in the biological process described with: macroautophagy; autophagosome maturation; cellular response to nitrogen starvation; autophagy of mitochondrion; autophagosome assembly. (120 aa) |
| | upd2 | Unpaired 2 (upd2) encodes a secreted molecule that acts at a distance as a ligand for the JAK/STAT signal transduction pathway. upd2 mutants are viable due to redundancy with other Upd-family genes. (406 aa) |
