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Adgf-B Adgf-B Nmdar2 Nmdar2 GluRIA GluRIA Nmdar1 Nmdar1 GluRIIA GluRIIA Ada Ada Adgf-D Adgf-D GluRIID GluRIID KaiR1D KaiR1D Dcr-2 Dcr-2 Adgf-E Adgf-E GluRIIB GluRIIB Syn Syn GluRIIE GluRIIE clumsy clumsy brp brp elav elav GluRIB GluRIB VGlut VGlut mGluR mGluR CG11155 CG11155 Grik Grik GluRIIC GluRIIC Adar Adar
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Adgf-BAdenosine deaminase-related growth factor B; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process. (520 aa)
Nmdar2NMDA receptor 2, isoform C; Ligand-gated ion channel activity; signaling receptor activity; NMDA glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity. (1083 aa)
GluRIAGlutamate receptor 1; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Forms ligand-gated ion channels which are activated by kainate; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (991 aa)
Nmdar1Glutamate [NMDA] receptor subunit 1; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation. (997 aa)
GluRIIAGlutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (907 aa)
AdaAdenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (337 aa)
Adgf-DAdenosine deaminase-related growth factor D (Adgf-D) encodes an adenosine deaminase involved in cell proliferation. (502 aa)
GluRIIDGlutamate receptor IID (GluRIID) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (902 aa)
KaiR1DKainate-type ionotropic glutamate receptor subunit 1D; It is involved in the biological process described with: calcium ion import across plasma membrane; regulation of synaptic activity; synaptic transmission, glutamatergic; positive regulation of neuromuscular synaptic transmission; modulation of chemical synaptic transmission. (853 aa)
Dcr-2Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. (1722 aa)
Adgf-EAdenosine deaminase-related growth factor E; It is involved in the biological process described with: inosine biosynthetic process. (539 aa)
GluRIIBGlutamate receptor IIB (GluRIIB) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (913 aa)
SynSynapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. (1041 aa)
GluRIIEGlutamate receptor IIE (GluRIIE) encodes an ion channel subunit involved in calcium ion transport. (897 aa)
clumsyClumsy, isoform B; Glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; ligand-gated ion channel activity; signaling receptor activity; kainate selective glutamate receptor activity. It is involved in the biological process described with: ion transport; modulation of chemical synaptic transmission; synaptic transmission, glutamatergic; regulation of synaptic activity. (1002 aa)
brpBruchpilot, isoform J; Bruchpilot (brp) encodes a cytoskeletal protein critical for structural integrity of electron-dense projection (T-bar) at pre-active zones. It contributes to Ca[2+] channel clustering, size regulation of the synaptic vesicle readily releaseable pool and anesthesia-resistant memory formation. (2238 aa)
elavProtein elav; Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism. Belongs to the RRM elav family. (483 aa)
GluRIBGlutamate receptor IB, isoform B; Ionotropic glutamate receptor activity; signaling receptor activity; extracellular ligand-gated ion channel activity; ligand-gated ion channel activity. It is involved in the biological process described with: cation transport. (1182 aa)
VGlutVesicular glutamate transporter, isoform A. (632 aa)
mGluRMetabotropic glutamate receptor; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. (976 aa)
CG11155FI01405p; Kainate selective glutamate receptor activity; signaling receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: ion transport; regulation of synaptic activity. (910 aa)
GrikGrik, isoform C; Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity; signaling receptor activity; kainate selective glutamate receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: ion transport; modulation of chemical synaptic transmission; synaptic transmission, glutamatergic; regulation of synaptic activity. (907 aa)
GluRIICGlutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. (940 aa)
AdarDouble-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. (669 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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