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ttm2 ttm2 pAbp pAbp betaTub56D betaTub56D ubl ubl ttm3 ttm3 Hrb98DE Hrb98DE Npl4 Npl4 Rab1 Rab1 Rab11 Rab11 DNAlig3 DNAlig3 Rab5 Rab5 SLIRP1 SLIRP1 Sod1 Sod1 Ufd1-like Ufd1-like Upf1 Upf1 XRCC1 XRCC1 ttm50 ttm50 Rab6 Rab6 Capr Capr CkIIalpha CkIIalpha Faf2 Faf2 CG4975 CG4975 IKKepsilon IKKepsilon LUBEL LUBEL Flo2 Flo2 Fmr1 Fmr1 futsch futsch mrj mrj HnRNP-K HnRNP-K TBPH TBPH Dhx15 Dhx15 Flo1 Flo1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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ttm2Mitochondrial import inner membrane translocase subunit TIM50-B; Tiny tim 2 (ttm2) encodes a mitochondrial inner membrane protein that is involved in mitochondrial protein translocation and maintenance of mitochondrial membrane potential; Belongs to the TIM50 family. (409 aa)
pAbpPolyadenylate-binding protein; Binds the poly(A) tail of mRNA. Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex. Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively. The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 [...] (634 aa)
betaTub56DTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (456 aa)
ublUbiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process. (73 aa)
ttm3Mitochondrial import inner membrane translocase subunit TIM50-A; Tiny tim 3 (ttm3) encodes a mitochondrial inner membrane protein that is involved in mitochondrial protein translocation and maintenance of mitochondrial membrane potential; Belongs to the TIM50 family. (343 aa)
Hrb98DEHeterogeneous nuclear ribonucleoprotein at 98DE (Hrb98DE) encodes a nuclear RNA-binding protein. It controls hnRNA stability, splicing, IRES-dependent translation, and translational repression. It represents one of the main targets of the poly(ADP-ribosyl)ation pathway. It also regulates tissue polarity patterning and germ-line stem cell fate. (365 aa)
Npl4Nuclear protein localization protein 4 homolog; May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. Belongs to the NPL4 family. (652 aa)
Rab1FI01544p; Rab1 (Rab1) encodes a small GTPase which regulates endoplasmic reticulum to Golgi and intra Golgi trafficking through different effectors. It has been involved in Notch signaling, cell migration, autophagy and cytokinesis. (205 aa)
Rab11Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. (214 aa)
DNAlig3DNA ligase 3 (DNAlig3) encodes an ATP-dependent DNA ligase that is involved in the repair of nuclear and mitochondrial single- and double-strand DNA breaks. (806 aa)
Rab5Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. (219 aa)
SLIRP1SRA stem-loop interacting RNA binding protein 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA processing; regulation of RNA metabolic process. (90 aa)
Sod1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
Ufd1-likeUbiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway; Belongs to the UFD1 family. (316 aa)
Upf1Regulator of nonsense transcripts 1 homolog; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity). (1180 aa)
XRCC1XRCC1 protein; Damaged DNA binding. It is involved in the biological process described with: base-excision repair; single strand break repair. (614 aa)
ttm50Mitochondrial import inner membrane translocase subunit TIM50-C; Tiny tim 50 (ttm50) encodes a mitochondrial inner membrane protein that is involved in mitochondrial protein translocation and maintenance of mitochondrial membrane potential. It plays active roles in regulating metabolic levels for modulation of growth in development. (428 aa)
Rab6Ras-related protein Rab6; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regula [...] (208 aa)
CaprCaprin (Capr) encodes an RNA-binding translational regulator that is present in cytoplasmic RNA granules (neuronal granules and stress granules). It modulates diverse cellular processes including neuronal function, cell proliferation and differentiation through post-transcriptional regulation of target RNAs. (961 aa)
CkIIalphaCasein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. (336 aa)
Faf2Fas-associated factor 2 (Faf2) encodes a putative ubiquitin ligase with a proteosome dependent function. (464 aa)
CG4975Uncharacterized protein, isoform C. (418 aa)
IKKepsilonI-kappaB kinase epsilon (IKKepsilon) encodes a serine-threonine kinase that targets the inhibitor of apoptosis encoded by Diap1 for degradation. It also negatively regulates protein kinase C and the dynein adaptor encoded nuf. The product of IKKepsilon contributes to the specification of bristle cells, bristle cell morphogenesis, oocyte polarity, and dendrite development. (720 aa)
LUBELE3 ubiquitin-protein ligase lubel; E3 ubiquitin-protein ligase which conjugates linear 'Met- 1'- and 'Lys-63'-linked polyubiquitin chains to substrates and plays a crucial role in the NF-kappa-B intestinal inflammatory response to oral infection and in the heat stress response. Preferentially interacts with 'Lys-63'-linked, and to a lesser extent 'Lys-48'-linked, polyubiquitin chains. Upon oral infection with a Gram-negative bacterium E.carotovora subsp. carotovora 15, functions with the E2 ubiquitin- conjugating enzyme Ubc10 to mediate the conjugation of 'Lys-63'- and linear 'Met-1'-l [...] (2892 aa)
Flo2Flotillin-2; Flotillin 2 (Flo2) encodes encodes a scaffold protein that contributes to the anti-parasitoid immune response and the secretion and spreading of the ligands encoded by wg and hh; Belongs to the band 7/mec-2 family. Flotillin subfamily. (448 aa)
Fmr1Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa)
futschMicrotubule-associated protein futsch; During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by Futsch. Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching. Translation is repressed by [...] (5495 aa)
mrjMrj, isoform E; Unfolded protein binding; chaperone binding. It is involved in the biological process described with: chaperone-mediated protein folding; chaperone cofactor-dependent protein refolding; protein folding. (346 aa)
HnRNP-KHeterogeneous nuclear ribonucleoprotein K (HnRNP-K) encodes a member of the hnRNP family of DNA/RNA binding proteins. It localizes, along with other hnRNPs, in nucleoplasmic omega speckles. It is involved in gene regulation, post-transcriptional RNA processing and RNA transport. (502 aa)
TBPHTAR DNA-binding protein-43 homolog (TBPH) encodes an RNA-binding protein that belongs to the hnRNP family. It contributes to synaptic growth of motor neurons and glial wrapping. (531 aa)
Dhx15DEAH-box helicase 15, isoform A; RNA helicase activity; RNA binding; ATP binding. It is involved in the biological process described with: positive regulation of p38MAPK cascade; mRNA splicing, via spliceosome. (729 aa)
Flo1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (430 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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