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Ir11a Ir11a Obp59a Obp59a Gr59d Gr59d Or59a Or59a Gr59e Gr59e Gr10b Gr10b lush lush Gr68a Gr68a Or67a Or67a Or65b Or65b Or65c Or65c Or22a Or22a Or22b Or22b Obp83cd Obp83cd Obp83ef Obp83ef Or33c Or33c Gr36b Gr36b Gr36c Gr36c Or85b Or85b Or88a Or88a Gr93d Gr93d Or49a Or49a Ir48c Ir48c Ir48b Ir48b Or47b Or47b Or43b Or43b Obp56c Obp56c Gr63a Gr63a CG3216 CG3216 Obp84a Obp84a Ir75c Ir75c Ir75b Ir75b CG10738 CG10738 gdl gdl sra sra Gr43a Gr43a CG31183 CG31183 CG34357 CG34357
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Ir11aIonotropic receptor 11a; Ligand-gated ion channel activity. It is involved in the biological process described with: sensory perception of taste; detection of chemical stimulus. (642 aa)
Obp59aOdorant-binding protein 59a; Odorant-binding protein required for hygrotaxis behavior in humidity-detecting sensilla; Belongs to the PBP/GOBP family. (202 aa)
Gr59dPutative gustatory receptor 59d; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (390 aa)
Or59aOdorant receptor 59a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to ethyl acetate, anisole, hexanoic acid, and pyrazines. (379 aa)
Gr59ePutative gustatory receptor 59e; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (399 aa)
Gr10bPutative gustatory receptor 10b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr10a subfamily. (373 aa)
lushGeneral odorant-binding protein lush; Odorant-binding protein required for olfactory behavior and for activity of pheromone-sensitive neurons. Binds to alcohols and mediates avoidance behavior to high concentrations of alcohols, the alcohol-binding possibly resulting in activation of receptors on T2B neurons, the activation of these receptors inhibiting these neurons. Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Required for cVA response, probably by [...] (153 aa)
Gr68aGustatory receptor 68a; Dsx-dependent essential component of pheromone-driven courtship behavior. Recognizes a female pheromone involved in the second step (tapping step) of the courtship display which is essential for efficient execution of the entire courtship sequence and timely mating. Required for detection of the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) and courtship suppression is mediated by the rele [...] (389 aa)
Or67aOdorant receptor 67a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to benzaldehyde and acetophenone. (407 aa)
Or65bPutative odorant receptor 65b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity); Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily. (406 aa)
Or65cPutative odorant receptor 65c; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity); Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily. (410 aa)
Or22aOdorant receptor 22a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses ethyl butyrate and to esters in more general. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally resp [...] (397 aa)
Or22bOdorant receptor 22b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses to esters. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. (397 aa)
Obp83cdOdorant-binding protein 83cd; Odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus. (242 aa)
Obp83efOdorant-binding protein 83ef; Odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus. (245 aa)
Or33cOdorant receptor 33c; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). (384 aa)
Gr36bPutative gustatory receptor 36b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (391 aa)
Gr36cPutative gustatory receptor 36c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (390 aa)
Or85bOdorant receptor 85b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to 2-heptanone, amyl acetate, and butyl acetate. Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily. (390 aa)
Or88aOdorant receptor 88a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (401 aa)
Gr93dGustatory receptor; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (381 aa)
Or49aOdorant receptor 49a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanol and 2-heptanone; Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily. (396 aa)
Ir48cIonotropic receptor 48c; Ligand-gated ion channel activity. It is involved in the biological process described with: Golgi organization; protein secretion; detection of chemical stimulus. (561 aa)
Ir48bIonotropic receptor 48b; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (600 aa)
Or47bOdorant receptor 47b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Plays an important role in sociosexual interactions since its enhances courtship in a pheromone- dependent manner. (412 aa)
Or43bOdorant receptor 43b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (403 aa)
Obp56cOdorant-binding protein 56c, isoform B; Odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus. (245 aa)
Gr63aGustatory and odorant receptor 63a; Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a. (489 aa)
CG3216Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP biosynthetic process; signal transduction; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP-mediated signaling. (1161 aa)
Obp84aGeneral odorant-binding protein 84a; Pheromone binding; odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus. (221 aa)
Ir75cIonotropic glutamate receptor activity; signaling receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus involved in sensory perception. (623 aa)
Ir75bIonotropic receptor 75b; Ligand-gated ion channel activity; ionotropic glutamate receptor activity. It is involved in the biological process described with: detection of chemical stimulus involved in sensory perception. (605 aa)
CG10738Guanylate cyclase activity; peptide receptor activity; ATP binding; signaling receptor activity. (1250 aa)
gdlGonadal protein gdl; Belongs to the gonadal family. (194 aa)
sraProtein sarah; Required for elongation of meiosis I spindle. Critical for ovulation, meiotic progression in oocytes and female courtship behavior, including their postmating changes. Regulates female meiosis by controlling calcineurin activity in the germline. Has a role in calcium signaling during egg activation; bcd mRNA polyadenylation and translation in the oocyte. Belongs to the RCAN family. (292 aa)
Gr43aGustatory receptor for sugar taste 43a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies. (453 aa)
CG31183ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: protein phosphorylation; receptor guanylyl cyclase signaling pathway; cGMP-mediated signaling; signal transduction; cGMP biosynthetic process. (1417 aa)
CG34357Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP-mediated signaling; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP biosynthetic process; signal transduction. (1689 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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