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Zpr1 Zpr1 Sod1 Sod1 park park ZnT35C ZnT35C Irp-1B Irp-1B Irp-1A Irp-1A RpL32 RpL32 ZnT41F ZnT41F Zip42C.1 Zip42C.1 Tsf3 Tsf3 Ire1 Ire1 Zip88E Zip88E Zip42C.2 Zip42C.2 Mvl Mvl ZnT63C ZnT63C Atox1 Atox1 ATP7 ATP7 MtnB MtnB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Zpr1LD37736p; Zpr1 (Zpr1) encodes a protein that functions downstream of the EGFR and other tyrosine kinase receptors. It also contributes to the assembly of spliceosome snRNPs. In the developing tracheal system it is required for terminal cell lumen formation. (457 aa)
Sod1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
parkParkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. (482 aa)
ZnT35CZinc transporter 35C (ZnT35C) encodes a protein involved in cellular and organismal zinc efflux that plays a major role in the detoxification of zinc excess. ZnT35C is a target of the metal-responsive transcription factor encoded by MTF-1. (472 aa)
Irp-1BIron regulatory protein 1B (Irp-1B) encodes a cytosolic aconitase highly homologous to the product of Irp-1A; Belongs to the aconitase/IPM isomerase family. (899 aa)
Irp-1AIron regulatory protein 1A (Irp-1A) encodes a cytosolic aconitase that under iron deficiency (or if cytosolic superoxide is present) loses its iron-sulfur cluster, changes confirmation and binds iron regulatory elements (so far identified on the products of SdhB and Fer1HCH mRNAs); Belongs to the aconitase/IPM isomerase family. (902 aa)
RpL3260S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
ZnT41FZinc ion transmembrane transporter activity. It is involved in the biological process described with: detoxification of zinc ion; regulation of sequestering of zinc ion; zinc ion transport; zinc ion transmembrane transport; response to zinc ion. (498 aa)
Zip42C.1Zinc/iron regulated transporter-related protein 42C.1 (Zip42C.1) encodes a plasma membrane resident zinc transporter belonging to the Zinc-Iron Permease family. It works together with the products of Zip42C.2 and Zip89B in dietary zinc absorption. (352 aa)
Tsf3Transferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (714 aa)
Ire1Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation. (1074 aa)
Zip88EZinc/iron regulated transporter-related protein 88E; Zinc ion transmembrane transporter activity. It is involved in the biological process described with: zinc ion transmembrane transport. (366 aa)
Zip42C.2Zinc/iron regulated transporter-related protein 42C.2 (Zip42C.2) encodes a protein involved in zinc detoxification and zinc transmembrane import. (310 aa)
MvlMalvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn[2+] and Fe[2+]. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling. (639 aa)
ZnT63CZinc transporter 63C, isoform F; Zinc transporter 63C (ZnT63C) encodes a plasma membrane resident zinc transporter belonging to the zinc transporter family that is mainly responsible for zinc export from the cell or into organelles. It plays a key role in effluxing zinc from enterocytes into circulation during dietary zinc absorption. (545 aa)
Atox1Antioxidant 1 copper chaperone (Atox1) null mutants are unable to develop on low-copper food. Furthermore, the intestinal copper importer encoded by Ctr1B, which is regulated by copper demand, fails to be induced upon copper starvation in Atox1 mutant larvae, while intestinal metallothionein is upregulated. This suggests intestinal copper accumulation, combined with insufficient delivery to the rest of the body. (89 aa)
ATP7ATP7, isoform B; ATP7 (ATP7) encodes a copper transmembrane transporter involved in cuticle pigmentation, copper homeostasis and larval development. (1254 aa)
MtnBMetallothionein-2; Metallothionein B (MtnB) encodes one of the five metallothioneins. They are metal-binding polypeptides that coordinate both physiological and xenobiotic metal ions, either for homeostasis or detoxification purposes. The product of MtnB shows a preference towards divalent metal ion binding. (43 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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