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Obp83a Obp83a Obp56d Obp56d Ir8a Ir8a Obp59a Obp59a Obp58b Obp58b Or59b Or59b lush lush Obp69a Obp69a Or67d Or67d Or67c Or67c Obp19b Obp19b Obp19d Obp19d Or22a Or22a Obp83cd Obp83cd Obp83ef Obp83ef Obp83b Obp83b Or82a Or82a Obp28a Obp28a Or35a Or35a ato ato Or98a Or98a Or42b Or42b Opbp Opbp Obp57c Obp57c Obp57a Obp57a Or56a Or56a Or49b Or49b Or49a Or49a Mat1 Mat1 Or43b Or43b Obp84a Obp84a Obp19a Obp19a Obp44a Obp44a Obp57b Obp57b
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Obp83aGeneral odorant-binding protein 83a; Pheromone binding; odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus; sensory perception of smell. (174 aa)
Obp56dGeneral odorant-binding protein 56d; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (131 aa)
Ir8aIonotropic receptor 8a (Ir8a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as a co-receptor together with ligand-specific IRs (in a probable heterotetrameric complex) to detect diverse organic acids; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (936 aa)
Obp59aOdorant-binding protein 59a; Odorant-binding protein required for hygrotaxis behavior in humidity-detecting sensilla; Belongs to the PBP/GOBP family. (202 aa)
Obp58bOdorant-binding protein 58b; Odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus. (203 aa)
Or59bOdorant receptor 59b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Plays also a role in the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. (398 aa)
lushGeneral odorant-binding protein lush; Odorant-binding protein required for olfactory behavior and for activity of pheromone-sensitive neurons. Binds to alcohols and mediates avoidance behavior to high concentrations of alcohols, the alcohol-binding possibly resulting in activation of receptors on T2B neurons, the activation of these receptors inhibiting these neurons. Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Required for cVA response, probably by [...] (153 aa)
Obp69aGeneral odorant-binding protein 69a; Odorant-binding protein required for olfactory behavior and activity of pheromone-sensitive neurons in response to the male- specific pheromone cis-vaccenyl acetate (cVA). Modulates social responsivity differently in males and females, regulating male aggression and female receptivity respectively. (148 aa)
Or67dOdorant receptor 67d; Plays a role in detection and sensitivity to pheromones and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Necessary to mediate behavioral responses to cVA by regulating both male and female mating behavior. Activation of Or67d neurons by cVA inhibits courtship of other males, whereas in females their activation promotes receptivity to othe [...] (391 aa)
Or67cOdorant receptor 67c; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (404 aa)
Obp19bOdorant-binding protein 19b; Odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus. (163 aa)
Obp19dGeneral odorant-binding protein 19d; Odorant binding; pheromone binding. It is involved in the biological process described with: sensory perception of chemical stimulus; sensory perception of smell; Belongs to the PBP/GOBP family. (150 aa)
Or22aOdorant receptor 22a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses ethyl butyrate and to esters in more general. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally resp [...] (397 aa)
Obp83cdOdorant-binding protein 83cd; Odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus. (242 aa)
Obp83efOdorant-binding protein 83ef; Odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus. (245 aa)
Obp83bPheromone-binding protein-related protein 6; Odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus. (141 aa)
Or82aOdorant receptor 82a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (385 aa)
Obp28aGeneral odorant-binding protein 28a; Pheromone binding; odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus. (143 aa)
Or35aOdorant receptor 35a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to esters. Involved in the behavioral responses to butanol, pentanol, hexanol, octanol, propyl acetate, and butyl acetate. (409 aa)
atoProtein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection. (312 aa)
Or98aOdorant receptor 98a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (397 aa)
Or42bOdorant receptor 42b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to ethyl acetate and pentyl acetate. (399 aa)
OpbpOptix-binding protein (Opbp) encodes a Zn finger protein that can bind to the Six-family transcription factor encoded by Optix. (562 aa)
Obp57cGeneral odorant-binding protein 57c; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (149 aa)
Obp57aGeneral odorant-binding protein 57a; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (169 aa)
Or56aOdorant receptor 56a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Specific receptor for geosmin, a microbial odorant that constitutes an ecologically relevant stimulus that alerts flies to the presence of harmful microbes and induces avoidance behavior. (419 aa)
Or49bOdorant receptor 49b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (375 aa)
Or49aOdorant receptor 49a; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanol and 2-heptanone; Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a subfamily. (396 aa)
Mat1CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. (320 aa)
Or43bOdorant receptor 43b; Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. (403 aa)
Obp84aGeneral odorant-binding protein 84a; Pheromone binding; odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus. (221 aa)
Obp19aGeneral odorant-binding protein 19a; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (146 aa)
Obp44aOdorant-binding protein 44a, isoform A; Odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus. (143 aa)
Obp57bGeneral odorant-binding protein 57b; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid. (141 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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