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Ubi-p63E Ubi-p63E CG11700 CG11700 Xbp1 Xbp1 Atf6 Atf6 Best3 Best3 Ubi-p5E Ubi-p5E IKKepsilon IKKepsilon
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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co-expression
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Your Input:
Ubi-p63EPolyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradatio [...] (763 aa)
CG11700Ubiquitin protein ligase binding; protein tag. It is involved in the biological process described with: determination of adult lifespan; negative regulation of reproductive process; modification-dependent protein catabolic process; protein ubiquitination. (301 aa)
Xbp1X box binding protein-1 (Xbp1) encodes a transcription factor that mediates the unfolded protein response. Xbp1 mRNA undergoes splicing after being cleaved by the product of Ire1, inducing the expression of ER quality control transcripts. Xbp1 mutants fail to develop beyond the 2nd instar larval stage, indicative of a requirement to resolve inherent ER stress during normal development. (498 aa)
Atf6Atf6, isoform C; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated. (741 aa)
Best3Bestrophin 3 (Best3) encodes a paralog of the product of Best1, a Ca-activated Cl channel. A C-terminal domain inhibits the Cl channel function so that the product of Best3 does not produce current at physiological transmembrane voltages; Belongs to the bestrophin family. (535 aa)
Ubi-p5EUbiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. (534 aa)
IKKepsilonI-kappaB kinase epsilon (IKKepsilon) encodes a serine-threonine kinase that targets the inhibitor of apoptosis encoded by Diap1 for degradation. It also negatively regulates protein kinase C and the dynein adaptor encoded nuf. The product of IKKepsilon contributes to the specification of bristle cells, bristle cell morphogenesis, oocyte polarity, and dendrite development. (720 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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