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Cbs Cbs Spat Spat CG5103 CG5103 Eaat1 Eaat1 CG8036 CG8036 Loxl1 Loxl1 Smvt Smvt 14-3-3zeta 14-3-3zeta Eaat2 Eaat2 PGRP-LB PGRP-LB Trpm Trpm Eip55E Eip55E Aprt Aprt ras ras
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CbsCystathionine beta-synthase (Cbs) encodes an enzyme involved in endoplasmic reticulum stress response; Belongs to the cysteine synthase/cystathionine beta- synthase family. (522 aa)
SpatSerine pyruvate aminotransferase (Spat) encodes an alanine-glyoxylate transaminase involved in glyoxylate catabolism. (394 aa)
CG5103FI06132p; Transketolase activity; thiamine pyrophosphate binding. (623 aa)
Eaat1Excitatory amino acid transporter 1 (Eaat1) encodes a transmembrane protein with a glutamate:sodium symporter activity. It is regulated by Notch signalling and contributes to larval locomotion and lifespan. (479 aa)
CG8036LP07963p; Transketolase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: regulation of chromatin silencing. (626 aa)
Loxl1Lysyl oxidase-like 1 (Loxl1) encodes a protein-lysine 6-oxidase that might be involved in euchromatinization and gene regulation. (360 aa)
SmvtSodium-dependent multivitamin transporter (Smvt) encodes a transmembrane protein responsible for translocation of vitamins, and other essential cofactors such as biotin, pantothenate and lipoate, in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (591 aa)
14-3-3zeta14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. (248 aa)
Eaat2Excitatory amino acid transporter 2 (Eaat2) encodes a transmembrane protein involved in aspartate and taurine transport. (579 aa)
PGRP-LBPeptidoglycan recognition protein LB (PGRP-LB) encodes a secreted protein with an amidase activity that scavenges DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It negatively regulates the immune deficiency pathway; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (255 aa)
TrpmTransient receptor potential cation channel trpm; Calcium channel mediating constitutive calcium ion entry. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. (2023 aa)
Eip55EEcdysone-induced protein 55E (Eip55E) encodes a protein involved in glutathione biosynthesis. (393 aa)
AprtAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)
rasInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (590 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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