node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
14-3-3zeta | CG5103 | FBpp0087500 | FBpp0074898 | 14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. | FI06132p; Transketolase activity; thiamine pyrophosphate binding. | 0.400 |
14-3-3zeta | CG8036 | FBpp0087500 | FBpp0081370 | 14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. | LP07963p; Transketolase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: regulation of chromatin silencing. | 0.423 |
Aprt | Smvt | FBpp0312099 | FBpp0085219 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Sodium-dependent multivitamin transporter (Smvt) encodes a transmembrane protein responsible for translocation of vitamins, and other essential cofactors such as biotin, pantothenate and lipoate, in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.512 |
Aprt | ras | FBpp0312099 | FBpp0423162 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.787 |
CG5103 | 14-3-3zeta | FBpp0074898 | FBpp0087500 | FI06132p; Transketolase activity; thiamine pyrophosphate binding. | 14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. | 0.400 |
CG5103 | CG8036 | FBpp0074898 | FBpp0081370 | FI06132p; Transketolase activity; thiamine pyrophosphate binding. | LP07963p; Transketolase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: regulation of chromatin silencing. | 0.901 |
CG5103 | Spat | FBpp0074898 | FBpp0070875 | FI06132p; Transketolase activity; thiamine pyrophosphate binding. | Serine pyruvate aminotransferase (Spat) encodes an alanine-glyoxylate transaminase involved in glyoxylate catabolism. | 0.438 |
CG5103 | ras | FBpp0074898 | FBpp0423162 | FI06132p; Transketolase activity; thiamine pyrophosphate binding. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.776 |
CG8036 | 14-3-3zeta | FBpp0081370 | FBpp0087500 | LP07963p; Transketolase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: regulation of chromatin silencing. | 14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. | 0.423 |
CG8036 | CG5103 | FBpp0081370 | FBpp0074898 | LP07963p; Transketolase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: regulation of chromatin silencing. | FI06132p; Transketolase activity; thiamine pyrophosphate binding. | 0.901 |
CG8036 | Spat | FBpp0081370 | FBpp0070875 | LP07963p; Transketolase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: regulation of chromatin silencing. | Serine pyruvate aminotransferase (Spat) encodes an alanine-glyoxylate transaminase involved in glyoxylate catabolism. | 0.424 |
CG8036 | ras | FBpp0081370 | FBpp0423162 | LP07963p; Transketolase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: regulation of chromatin silencing. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.778 |
Cbs | Eip55E | FBpp0076938 | FBpp0311547 | Cystathionine beta-synthase (Cbs) encodes an enzyme involved in endoplasmic reticulum stress response; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Ecdysone-induced protein 55E (Eip55E) encodes a protein involved in glutathione biosynthesis. | 0.999 |
Cbs | Spat | FBpp0076938 | FBpp0070875 | Cystathionine beta-synthase (Cbs) encodes an enzyme involved in endoplasmic reticulum stress response; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Serine pyruvate aminotransferase (Spat) encodes an alanine-glyoxylate transaminase involved in glyoxylate catabolism. | 0.950 |
Cbs | ras | FBpp0076938 | FBpp0423162 | Cystathionine beta-synthase (Cbs) encodes an enzyme involved in endoplasmic reticulum stress response; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.704 |
Eaat1 | Smvt | FBpp0079401 | FBpp0085219 | Excitatory amino acid transporter 1 (Eaat1) encodes a transmembrane protein with a glutamate:sodium symporter activity. It is regulated by Notch signalling and contributes to larval locomotion and lifespan. | Sodium-dependent multivitamin transporter (Smvt) encodes a transmembrane protein responsible for translocation of vitamins, and other essential cofactors such as biotin, pantothenate and lipoate, in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.415 |
Eaat2 | Smvt | FBpp0290531 | FBpp0085219 | Excitatory amino acid transporter 2 (Eaat2) encodes a transmembrane protein involved in aspartate and taurine transport. | Sodium-dependent multivitamin transporter (Smvt) encodes a transmembrane protein responsible for translocation of vitamins, and other essential cofactors such as biotin, pantothenate and lipoate, in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.443 |
Eip55E | Cbs | FBpp0311547 | FBpp0076938 | Ecdysone-induced protein 55E (Eip55E) encodes a protein involved in glutathione biosynthesis. | Cystathionine beta-synthase (Cbs) encodes an enzyme involved in endoplasmic reticulum stress response; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.999 |
Eip55E | Spat | FBpp0311547 | FBpp0070875 | Ecdysone-induced protein 55E (Eip55E) encodes a protein involved in glutathione biosynthesis. | Serine pyruvate aminotransferase (Spat) encodes an alanine-glyoxylate transaminase involved in glyoxylate catabolism. | 0.405 |
Smvt | Aprt | FBpp0085219 | FBpp0312099 | Sodium-dependent multivitamin transporter (Smvt) encodes a transmembrane protein responsible for translocation of vitamins, and other essential cofactors such as biotin, pantothenate and lipoate, in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.512 |