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corto corto Hr4 Hr4 rgn rgn TfAP-2 TfAP-2 vkg vkg Stat92E Stat92E pigs pigs NimC1 NimC1 yellow-b yellow-b Ets21C Ets21C Nox Nox Sod2 Sod2 twi twi Hr3 Hr3 dve dve hep hep upd1 upd1 Cyp18a1 Cyp18a1 Cat Cat rpr rpr Thor Thor Eip78C Eip78C Col4a1 Col4a1 Gal Gal wg wg NC2beta NC2beta CG9336 CG9336 puc puc p38a p38a AdoR AdoR Alp4 Alp4 nopo nopo Hr78 Hr78 GstD1 GstD1 mol mol nub nub Mmp1 Mmp1 kay kay Ilp8 Ilp8 Duox Duox fru fru bsk bsk chinmo chinmo sm sm NLaz NLaz rn rn Atf3 Atf3 Jra Jra zfh1 zfh1 Myc Myc Blimp-1 Blimp-1 LamC LamC
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second shell of interactors
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proteins of unknown 3D structure
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cortoCentrosomal and chromosomal factor; Corto (corto) encodes an Enhancer of Trithorax and Polycomb (ETP) protein that physically interacts with several Polycomb proteins (encoded by Pc, ph-d, ph-p, esc, E(z)) and ETP (encoded by Trl, Dsp1). It also interacts with the product of CycG, with the methylated product of RpL12 (RPL12K3me3), and co-regulates the transcription of genes involved in ribosome biogenesis. (550 aa)
Hr4Hormone receptor 4; Coordinates growth and maturation by mediating endocrine responses to the attainment of critical weight during larval development. Plays a central role in the genetic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a repressor of the early ecdysone-induced regulatory genes and an inducer of the ftz-f1 midprepupal competence factor. Belongs to the nuclear hormone receptor family. NR1 subfamily. (2123 aa)
rgnRegeneration, isoform B; DNA-(apurinic or apyrimidinic site) endonuclease activity; carbohydrate binding; DNA N-glycosylase activity. It is involved in the biological process described with: base-excision repair; tissue regeneration. (808 aa)
TfAP-2Transcription factor AP-2 (TfAP-2) encodes a transcription factor with essential roles in leg, proboscis, and central nervous system development. It mediates Notch signaling in the developing tarsus. (471 aa)
vkgViking, isoform A; Viking (vkg) encodes a subunit of Collagen IV and a major component of basement membranes. It is secreted by haemocytes and fat body cells and is required for the normal morphogenesis of many tissues. It also contributes to TGF-beta signalling in the early embryo and the developing Malpighian tubules. (1940 aa)
Stat92ESignal-transducer and activator of transcription protein at 92E (Stat92E) encodes a transcription factor that shuttles between the cytosol and nucleus and functions in the JAK/STAT pathway. Its roles include proliferation, growth control, organismal metabolism, cell competition, stem cell self-renewal, immunity and developmental patterning. (818 aa)
pigsGAS2-like protein pickled eggs; Essential for development and viability. Required for ovary development and oogenesis, and is essential for the development of the indirect flight muscles. May act as a negative regulator of the Notch signaling pathway in certain tissues, such as the muscle precursors and ovaries. May function as a linker protein between the actin and microtubule cytoskeletons; Belongs to the GAS2 family. (977 aa)
NimC1Nimrod C1, isoform B; It is involved in the biological process described with: defense response to bacterium; phagocytosis. (622 aa)
yellow-bYellow-b, isoform A; Yellow-b (yellow-b) is a member of the multifunctional yellow family of genes that encodes a protein involved in color pattering, eggshell integrity and mating behavior. (453 aa)
Ets21CDNA-binding protein D-ETS-6; Ets at 21C (Ets21C) encodes a stress-inducible transcription factor that binds specifically to purine-rich DNA motifs. It cooperates with transcription factors acting downstream of the MAP kinase pathways to fine tune gene expression in response to stress, such as infection or oncogene activation. (475 aa)
NoxNADPH oxidase (Nox) encodes a protein involved in calcium flux and smooth muscle contraction during ovulation. (1340 aa)
Sod2Superoxide dismutase 2 (Mn) (Sod2) encodes an enzyme that detoxifies superoxide radicals in mitochondria. The loss of Sod2 generates endogenous oxidative stress that results in reduced activity of critical mitochondrial enzymes, hypersensitivity to oxidative stress and neonatal lethality. A muscle restricted p38Kinase-Mef2-Sod2 signaling module influences life span and stress. (217 aa)
twiTwist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells. (490 aa)
Hr3Hormone receptor 3 (Hr3) encodes a protein induced directly by 20-hydroxyecdysone as a delayed-early response. It is required for tracheal air filling and ventral nerve cord condensation in embryos, for developmental progression through early metamorphosis, and in the prothoracic gland for ecdysteroid biosynthesis. (871 aa)
dveDefective proventriculus (dve) encodes a transcriptional repressor that binds to the K50 site. It is involved in developmental patterning, cell-type specification, and functional differentiation. (1024 aa)
hepDual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (1178 aa)
upd1Unpaired 1 (upd1) encodes a secreted glycoprotein that is able to act at a distance as the primary ligand for the JAK/STAT signaling pathway. Although semi-redundant with upd2 and upd3, upd1 depletion results in embryonic lethality with an atypical gap gene-like segmentation phenotype. (413 aa)
Cyp18a1Cytochrome P450-18a1 (Cyp18a1) encodes a P450 enzyme that inactivates the hormone 20 hydroxy ecdysone through addition of an OH group to the 26 carbon of the hormone molecule. It is expressed in many larval tissues. Cyp18a1 mutants result in prepupal lethality due to improper activation kinetics of the transcription factor encoded by ftz-f1. (538 aa)
CatCatalase (Cat) encodes an enzyme that catalyzes the decomposition of hydrogen peroxide. It reduces the amount of oxidative damage to biomolecules and protects cells from the toxic effects of reactive oxygen species. (506 aa)
rprCell death protein rpr; Reaper (rpr) encodes Reaper, Hid, Grim (RHG) protein. It contributes to the caspase dependent apoptosis by inhibiting the anti-apoptotic protein encoded by Diap1. (65 aa)
Thor4E-binding protein THOR; Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. (117 aa)
Eip78CEcdysone-induced protein 78C; Induces the early late puff 78C which triggers puparium formation and development. (862 aa)
Col4a1Collagen alpha-1(IV) chain; Collagen type IV alpha 1 (Col4a1) encodes a subunit of Collagen IV and a major component of basement membranes. It is required for muscle and epithelium integrity. (1779 aa)
GalBeta galactosidase (Gal) encodes a putative digestive enzyme that hydrolyses beta-galactosides into monosaccharides. Gal is highly expressed and enriched in the midgut, an organ involved in digestion; Belongs to the glycosyl hydrolase 35 family. (672 aa)
wgProtein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] (468 aa)
NC2betaProtein Dr1; Bifunctional basic transcription factor. Activates transcription of DPE (Downstream Promoter Element) containing promoters while repressing transcription of promoters which contain TATA elements. Together with Chrac-14, promotes nucleosome sliding of ATP-dependent nucelosome remodeling complexes. Belongs to the NC2 beta/DR1 family. (183 aa)
CG9336FI02856p. (148 aa)
pucPuckered, isoform A; Puckered (puc) encodes a serine/threonine protein phosphatase that mediates a feedback loop that regulates the Jun-N-terminal kinase pathway. (476 aa)
p38aP38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. (366 aa)
AdoRAdenosine receptor (AdoR) encodes a protein belongsING to the G protein-coupled receptor family (Class A) that functions via cAMP and PKA activation. It is involved in response to metabolic stress and neuromodulation. (774 aa)
Alp4Alkaline phosphatase 4; Important role in neural and renal epithelial function. (596 aa)
nopoNo poles (nopo) encodes a RING domain-containing E3 ubiquitin ligase that is essential for early embryogenesis. It positively regulates caspase-dependent cell death. (435 aa)
Hr78Hormone-receptor-like in 78 (Hr78) encodes a protein induced above a basal level by 20-hydroxyecdysone. Hr78 mutants die during mid-larval stages with defects in molting of the tracheal cuticle; Belongs to the nuclear hormone receptor family. NR2 subfamily. (601 aa)
GstD1Glutathione S-transferase D1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity. May be involved in detoxification. (209 aa)
molMoladietz, isoform A; Protein binding. It is involved in the biological process described with: protein localization; protein transport; long-term memory; response to oxidative stress. (474 aa)
nubProtein nubbin; DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. Repressed directly or indirectly by the BX-C homeotic proteins. Belongs to the POU transcription factor family. Class-2 subfamily. (961 aa)
Mmp1Matrix metalloproteinase 1 (Mmp1) encodes a proteinase that cleaves proteins in the extracellular matrix. It is involved in tissue histolysis and remodeling during metamorphosis, tracheal remodeling, wound healing, wing regeneration, neoplastic growth, and circadian behavior. It has been used as a reporter for JNK signaling since it is upregulated by the pathway. (584 aa)
kayTranscription factor kayak, isoforms A/B/F; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra. Belongs to the bZIP family. Fos subfamily. (755 aa)
Ilp8Insulin-like peptide 8 (Ilp8) encodes a divergent member of the insulin/IGF/relaxin-like family that acts through the relaxin receptor encoded by Lgr3. It coordinates growth status of tissues with developmental timing. (150 aa)
DuoxDual oxidase; Plays a role in innate immunity limiting microbial proliferation in the gut. Acts downstream of a hh-signaling pathway to induce the production of reactive oxygen species (ROS) in response to intestinal bacterial infection. May generate antimicrobial oxidative burst through its peroxidase-like domain. (1537 aa)
fruSex determination protein fruitless; Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associ [...] (960 aa)
bskStress-activated protein kinase JNK; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade. Exhibits cytoprotective activity in neuronal c [...] (372 aa)
chinmoZinc finger protein chinmo; Required for morphological differentiation of postmitotic neurons during postembryonic brain development. Ensures production of appropriate neuron subtypes within a lineage by preventing precocious generation of late neuronal types of that lineage. Acts as a downstream mediator of the transcriptional activator Stat92e and is required for the development of the eye- antennal disk which gives rise to the adult eye, antenna and head capsule, for transcriptional repression of the Notch receptor ligand Ser and for the self-renewal of cyst stem cells in the testis [...] (840 aa)
smSmooth, isoform T; Smooth (sm) encodes an RNA binding, heterogeneous nuclear ribonucleoprotein involved in axon guidance, mRNA processing, chemosensation, determination of lifespan and feeding behavior. (552 aa)
NLazNeural lazarillo, isoform B; Neural Lazarillo (NLaz) encodes an extracellular lipid binding protein of the Lipocalin family. It is regulated by JNK signaling and negatively regulates the IIS pathway. It contributes to longevity, stress resistance, and behavior. (245 aa)
rnZinc finger protein rotund; Transcription factor involved in imaginal disks development. Isoform rn is required in the wings, antenna, haltere, proboscis and legs disks, while isoform roe is required in the eye disk. Together with nab corepressor, it is involved in the initiation and maintenance of wingless (wg) expression in the wing hinge, by limiting the expression of wg to this compartment. Also required for the epithelial- mesenchymal transition branch of basolateral junctions signaling. Belongs to the krueppel C2H2-type zinc-finger protein family. (952 aa)
Atf3Activating transcription factor 3; Transcription factor which binds to the cAMP response element (CRE). Regulates metabolic and innate immune homeostasis, possibly by controlling appropriate expression of genes involved in peritrophic matrix composition and ensuring the normal digestive and immune function of the gut. Required for the expression of odorant receptors Or43b and Or47b ; Belongs to the bZIP family. ATF subfamily. (688 aa)
JraTranscription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Plays a role in dorsal closure. Belongs to the bZIP family. Jun subfamily. (372 aa)
zfh1Zinc finger protein 1; Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. (1206 aa)
MycMyc protein; Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiqui [...] (717 aa)
Blimp-1Blimp-1, isoform B; Blimp-1 (Blimp-1) encodes a zinc finger transcription repressor that is induced by 20-hydroxylecdysone and plays important roles for metamorphosis. It also contributes to embryonic trachea formation. (1216 aa)
LamCLamin-C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (By similarity). In spermatocytes, regulates cytokinesis during meiosis. (640 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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