STRINGSTRING
CG1924 CG1924 Eip63F-1 Eip63F-1 CG30378 CG30378 Stt3A Stt3A Sec61alpha Sec61alpha CG32022 CG32022 Sec61gamma Sec61gamma CG6870 CG6870 Calr Calr Tudor-SN Tudor-SN Xbp1 Xbp1 Cam Cam Hsc70Cb Hsc70Cb Acam Acam CG2918 CG2918 CG3566 CG3566 Cyt-b5 Cyt-b5 azot azot Sec61beta Sec61beta Debcl Debcl Atf6 Atf6 CG17770 CG17770 CG5024 CG5024 Sil1 Sil1 Stt3B Stt3B Droj2 Droj2 P58IPK P58IPK Trp1 Trp1 PEK PEK Itpr Itpr Psn Psn CG31960 CG31960 Sec63 Sec63 CG5157 CG5157 Cnx14D Cnx14D TRAM TRAM PIG-K PIG-K Caf1-180 Caf1-180 CG13526 CG13526 SERCA SERCA CG13898 CG13898
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CG1924Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. (570 aa)
Eip63F-1Calcium-binding protein E63-1; Ecdysone-induced protein 63F 1 (Eip63F-1) encodes a member of the EF-hand family of Ca[2+]-binding proteins, induced directly by 20-hydroxyecdysone in late third instar larvae. It is responsible for formation of the 63F early puff in the polytene chromosomes. (193 aa)
CG30378Uncharacterized protein; Calcium ion binding. (148 aa)
Stt3ACatalytic subunit 3A of the oligosaccharyltransferase complex, isoform A; Dolichyl-diphosphooligosaccharide-protein glycotransferase activity. It is involved in the biological process described with: protein N-linked glycosylation via asparagine; post-translational protein modification. (713 aa)
Sec61alphaSec61 alpha subunit (Sec61alpha) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel. (476 aa)
CG32022AT11343p; It is involved in the biological process described with: oogenesis; tail-anchored membrane protein insertion into ER membrane. (178 aa)
Sec61gammaProtein transport protein Sec61 gamma-2 subunit; Necessary for protein translocation in the endoplasmic reticulum. (68 aa)
CG6870GEO08203p1; Heme binding; electron transfer activity; Belongs to the cytochrome b5 family. (137 aa)
CalrCalreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). (406 aa)
Tudor-SNStaphylococcal nuclease domain-containing protein 1; Endonuclease which shows activity towards both DNA and RNA substrates. Has a role in translation regulation throught its association with the with the RNA- induced silencing complex (RISC). Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline. Together with piwi, might be involved in transposon repression in the germline. (926 aa)
Xbp1X box binding protein-1 (Xbp1) encodes a transcription factor that mediates the unfolded protein response. Xbp1 mRNA undergoes splicing after being cleaved by the product of Ire1, inducing the expression of ER quality control transcripts. Xbp1 mutants fail to develop beyond the 2nd instar larval stage, indicative of a requirement to resolve inherent ER stress during normal development. (498 aa)
CamCalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. (149 aa)
Hsc70CbHsc70Cb, isoform G; Hsc70Cb (Hsc70Cb) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. (836 aa)
AcamCalmodulin-related protein 97A; May be involved in calcium-mediated signal transduction. (148 aa)
CG2918EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. (923 aa)
CG3566Uncharacterized protein, isoform B; Heme binding; electron transfer activity; Belongs to the cytochrome b5 family. (117 aa)
Cyt-b5Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein which functions as an electron carrier for several membrane-bound oxygenases. (134 aa)
azotGEO08584p1; Ahuizotl (azot) encodes a calcium dependent protein that ensures the elimination of less fit cells. Fitness-based cell culling is used to maintain tissue health, delay aging, and extend lifespan. During development it also prevents malformations; Belongs to the calmodulin family. (148 aa)
Sec61betaSec61 beta subunit (Sec61beta) encodes a protein involved in the regulation of autophagy. (100 aa)
DebclDeath executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. (300 aa)
Atf6Atf6, isoform C; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated. (741 aa)
CG17770MIP05401p; Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization. (164 aa)
CG5024GEO08667p1; Calcium ion binding; enzyme regulator activity. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization. (165 aa)
Sil1Nucleotide exchange factor Sil1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for an ER lumenal chaperone of HSP70 family (By similarity). Belongs to the SIL1 family. (429 aa)
Stt3BCatalytic subunit 3B of the oligosaccharyltransferase complex; Dolichyl-diphosphooligosaccharide-protein glycotransferase activity. It is involved in the biological process described with: protein N-linked glycosylation via asparagine; post-translational protein modification. (774 aa)
Droj2DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding. (403 aa)
P58IPKLD25575p; Misfolded protein binding; chaperone binding. It is involved in the biological process described with: protein folding in endoplasmic reticulum. (498 aa)
Trp1Translocation protein 1, isoform B; Protein transmembrane transporter activity. It is involved in the biological process described with: posttranslational protein targeting to membrane, translocation. (428 aa)
PEKEukaryotic translation initiation factor 2-alpha kinase; Pancreatic eIF-2alpha kinase (PEK) encodes an endoplasmic reticulum (ER) transmembrane kinase and a component of the integrated stress response. During ER stress the product of PEK phosphorylates the translation initiation factor encoded by eIF2alpha resulting in the inhibition of most cap-dependent translation. This is especially important during the development of secretory tissues and the response to cellular stress; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1162 aa)
ItprInositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa)
PsnPresenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. (541 aa)
CG31960GEO02651p1; Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization; Belongs to the calmodulin family. (148 aa)
Sec63Secretory 63; Protein transmembrane transporter activity; RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation. (753 aa)
CG5157GEO11555p1; Electron transfer activity; heme binding; Belongs to the cytochrome b5 family. (119 aa)
Cnx14DCalnexin 14D; Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: endoplasmic reticulum unfolded protein response; protein folding. (639 aa)
TRAMTranslocating chain-associated membrane protein; It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane, translocation; Belongs to the TRAM family. (368 aa)
PIG-KPutative GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity); Belongs to the peptidase C13 family. (355 aa)
Caf1-180Chromatin assembly factor 1, p180 subunit (Caf1-180) encodes a component of the chromatin assembly factor-1, which couples DNA replication to histone deposition. The product of Caf1-180 is involved in nucleosome organization, DNA endoduplication and double-strand DNA break repair. (1183 aa)
CG13526Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. (154 aa)
SERCACalcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. (1020 aa)
CG13898GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. (151 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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