STRINGSTRING
Rab5 Rab5 CG11437 CG11437 CG11426 CG11426 CG11425 CG11425 laza laza Arf79F Arf79F dind dind Vps2 Vps2 Mtl Mtl wun2 wun2 wun wun Vps20 Vps20 Vps4 Vps4 CG11438 CG11438 Vps24 Vps24 TSG101 TSG101
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rab5Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. (219 aa)
CG11437RE35159p; Phosphatidate phosphatase activity; phosphatase activity; lipid phosphatase activity. It is involved in the biological process described with: phospholipid dephosphorylation; phospholipid metabolic process; signal transduction. (305 aa)
CG11426FI20175p1; Phosphatidate phosphatase activity; phosphatase activity; lipid phosphatase activity. It is involved in the biological process described with: signal transduction; phototransduction; phospholipid metabolic process; phospholipid dephosphorylation. (340 aa)
CG11425GH04282p; Lipid phosphatase activity; phosphatidate phosphatase activity; phosphatase activity. It is involved in the biological process described with: phospholipid dephosphorylation; phospholipid metabolic process; signal transduction. (305 aa)
lazaHL01743p; Lazaro (laza) encodes a protein involved in phototransduction, response to light intensity and thermotaxis. (334 aa)
Arf79FADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; has a role in Golgi organization and may modulate vesicle budding and uncoating within the Golgi apparatus (Probable). Has a role in eye development. Required for cleavage furrow ingression in embryonic cells. (182 aa)
dindDiamond, isoform A. (592 aa)
Vps2Vacuolar protein sorting 2 (Vps2) encodes an ion channel involved in the transmembrane transport of potassium. (256 aa)
MtlMig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. (195 aa)
wun2Wunen-2, isoform A; Wunen-2 (wun2) encodes a lipid phosphate phosphatase, an enzyme with an active site predicted to face extracellularly. It is required for germ cell migration and survival, acting partially redundantly with its paralog wun. (350 aa)
wunPutative phosphatidate phosphatase; Wunen (wun) encodes a lipid phosphate phosphatase with 6 transmembrane domains and an active site that is predicted to face extracellularly. It is required for germ cell migration and survival, septate junction function in the tracheal system and for heart formation; Belongs to the PA-phosphatase related phosphoesterase family. (379 aa)
Vps20Vacuolar protein sorting 20 (Vps20) encodes a member of the ESCRT-III complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, the product of Vps20 is also involved in abscission following cytokinesis. (212 aa)
Vps4Vacuolar protein sorting 4 (Vps4) encodes an AAA family ATPase. It catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes. It functions in endosomal sorting of cargo into the multivesicular body for lysosomal degradation, abscission during cell division, virus release and nuclear envelope membrane sealing after cell division. (442 aa)
CG11438RH32172p; Phosphatidate phosphatase activity; phosphatase activity; lipid phosphatase activity. It is involved in the biological process described with: phospholipid dephosphorylation; phospholipid metabolic process; signal transduction. (341 aa)
Vps24Vacuolar protein sorting 24 (Vps24) encodes an essential subunit of ESCRT-III, one of the endosomal sorting complexes required for transport (ESCRT). It is involved in membrane remodeling in diverse cellular processes, such as multi-vesicular body biogenesis, cytokinesis and virus budding. (223 aa)
TSG101Tumor susceptibility gene 101 (TSG101) encodes an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III. Its roles include endosomal sorting of ubiquitinated cargoes, which is important for signaling regulation, cytokinesis, and budding of viruses and exovesicles. (408 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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