STRINGSTRING
Ythdf Ythdf Mettl14 Mettl14 vir vir Hakai Hakai Fmr1 Fmr1 drosha drosha fl(2)d fl(2)d pasha pasha Mettl3 Mettl3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
YthdfYTH domain-containing family protein; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA processing and stability. (700 aa)
Mettl14N6-adenosine-methyltransferase non-catalytic subunit; Non-catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the heterodimer formed with Ime4/Mettl3, Mettl14 constitutes the RNA- binding scaffold that recognizes the substrate rather than the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and pro [...] (397 aa)
virProtein virilizer; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Required for proper inclusion of regulated exons in Ubx trans [...] (1854 aa)
HakaiE3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase required during early development. E3 ubiquitin-protein ligases mediate ubiquitination of target proteins. Required for epithelial integrity and midgut morphogenesis. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. Belongs to the Hakai family. (473 aa)
Fmr1Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa)
droshaRibonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. (1327 aa)
fl(2)dPre-mRNA-splicing regulator female-lethal(2)D; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Required for proper inclusion of [...] (536 aa)
pashaPartner of drosha (pasha) encodes a protein involved in oogenesis and miRNA processing. (642 aa)
Mettl3N6-adenosine-methyltransferase MT-A70-like protein; Catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the heterodimer formed with Mettl14, constitutes the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy [...] (608 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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