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CG5860 CG5860 Atg5 Atg5 Traf6 Traf6 Atg8a Atg8a Dcp-1 Dcp-1 Atg101 Atg101 Atg3 Atg3 CG33128 CG33128 CG31661 CG31661 Atg4a Atg4a Rheb Rheb CG6508 CG6508 CG17134 CG17134 Sirt1 Sirt1 Uvrag Uvrag Atg13 Atg13 Atg4b Atg4b CG17283 CG17283 CG5863 CG5863 Lamp1 Lamp1 Atg7 Atg7 Sply Sply CG10104 CG10104 Atg12 Atg12 Nedd4 Nedd4 Atg1 Atg1 PGRP-LE PGRP-LE Cdc42 Cdc42 Atg9 Atg9 Myd88 Myd88 Smurf Smurf S6k S6k Gcn2 Gcn2 CG31928 CG31928 CG31926 CG31926 Smox Smox Atg10 Atg10 Bace Bace Atg8b Atg8b cathD cathD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CG5860Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; cell death; protein catabolic process; Belongs to the peptidase A1 family. (370 aa)
Atg5Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). (269 aa)
Traf6TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr. (475 aa)
Atg8aAutophagy-related 8a (Atg8a) encodes a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a product has roles in autophagosome formation, maintaining neuromuscular function and normal lifespan. (121 aa)
Dcp-1Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy. (323 aa)
Atg101Autophagy-related 101 (Atg101) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. (218 aa)
Atg3Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy. (330 aa)
CG33128LP12231p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family. (405 aa)
CG31661MIP16848p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: eggshell chorion assembly; cell death; protein catabolic process; proteolysis; Belongs to the peptidase A1 family. (393 aa)
Atg4aCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (411 aa)
RhebGTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity (By similarity). Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K through activation of TORC1 signaling. May also have a role in activating TORC2 signaling. (182 aa)
CG6508Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: protein catabolic process; proteolysis; Belongs to the peptidase A1 family. (423 aa)
CG17134RE02351p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family. (391 aa)
Sirt1NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. (823 aa)
UvragUV-resistance associated gene (Uvrag) encodes a protein that regulates autophagy and vesicle trafficking with the product of Atg6 and class C vacuolar protein sorting complexes. With the products of Atg6 and Pi3K59F, It forms a PI3K(III) complex and plays roles in receptor downregulation and the establishment of proper cell polarity. It is also critical for proper organ rotation during development by controlling receptor endocytosis and subsequent degradation. (696 aa)
Atg13Autophagy-related protein 13 homolog; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1- Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells. (523 aa)
Atg4bCysteine protease; Autophagy-related 4b (Atg4b) encodes a cysteine protease that cleaves the precursor product of Atg8a at the C-terminal region, thereby initiating autophagosome formation; Belongs to the peptidase C54 family. (668 aa)
CG17283Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: protein catabolic process; proteolysis; Belongs to the peptidase A1 family. (465 aa)
CG5863Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family. (395 aa)
Lamp1FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. (318 aa)
Atg7Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. (684 aa)
SplySphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. Belongs to the group II decarboxylase family. Sphingosine- 1-phosphate lyase subfamily. (545 aa)
CG10104Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; cell death; Belongs to the peptidase A1 family. (404 aa)
Atg12Autophagy protein 12-like; Required for autophagy. (111 aa)
Nedd4E3 ubiquitin-protein ligase Nedd-4; Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down- regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation. (1007 aa)
Atg1Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. (855 aa)
PGRP-LEPeptidoglycan-recognition protein LE; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram- negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is req [...] (345 aa)
Cdc42Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. (191 aa)
Atg9Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (852 aa)
Myd88Myd88 (Myd88) encodes an adaptor protein involved in in the Toll pathway functioning downstream of the product of Tl and upstream of the product of tub. Toll pathway is a signaling cascade that plays a key role in various developmental and immune processes, notably embryonic dorsoventral patterning and regulation of antimicrobial peptides. (537 aa)
SmurfE3 ubiquitin-protein ligase Smurf1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation. (1061 aa)
S6kRibosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. (490 aa)
Gcn2Gcn2, isoform C; Gcn2 (Gcn2) encodes a kinase activated during amino acid starvation to phosphorylate the eIF2 subunit encoded by eIF2alpha. Gcn2 product plays roles in ageing, dpp signalling, dietary choice and response to infection. (1591 aa)
CG31928IP19042p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; cell death; Belongs to the peptidase A1 family. (418 aa)
CG31926Uncharacterized protein, isoform A; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; cell death; eggshell chorion assembly; Belongs to the peptidase A1 family. (410 aa)
SmoxMothers against decapentaplegic homolog; Smad on X (Smox) encodes the primary transcription factor that mediates Activin signalling. Upon phosphorylation by the receptor encoded by babo, it forms a complex with the co-Smad protein encoded by Med. This complex translocates to the nucleus where it regulates expression of target genes. (486 aa)
Atg10Autophagy-related 10, isoform B; Atg12 transferase activity; Atg12 conjugating enzyme activity. It is involved in the biological process described with: cellular protein modification process; macroautophagy. (172 aa)
BaceBeta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family. (372 aa)
Atg8bAutophagy-related 8b, isoform A; Microtubule binding; protein tag; ubiquitin protein ligase binding; GABA receptor binding. It is involved in the biological process described with: macroautophagy; autophagosome maturation; cellular response to nitrogen starvation; autophagy of mitochondrion; autophagosome assembly. (120 aa)
cathDCathD, isoform A; cathD (cathD) encodes a protein involved in apoptosis and the defense response to Gram-negative bacteria; Belongs to the peptidase A1 family. (392 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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